Dcon010723.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila conformis
Gene Symbol
E2f1
Assembly
GCA_035041375.1
Location
JAWNLE010000865.1:148354-153303[+]

Transcription Factor Domain

TF Family
E2F
Domain
E2F_TDP domain
PFAM
PF02319
TF Group
Helix-turn-helix
Description
This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.1e-30 6.6e-27 93.1 0.1 2 65 280 343 279 343 0.98

Sequence Information

Coding Sequence
ATGTCGAAATTTTTTATAACCGCCGcgcccaacagcaacaacaacaacaataatagcaacacgcagcgtcagcagcagatTTATGGCGGCGCAACTCAGGTGGTACGCAAGCTCAGTTACGATCCGCTCggcaccaacaataacaacaattataacaacaatattgtgatcaaaaatgaaaagttgctGGAAATTGATTACGAGCACAGCGGCGGCAAcgataacagcagcagcaacaacaacaataacaataatggcAGCGGCGTCGCTGCCCACCTGCGAGATCACGTATACATAAGTCTGAACAAAGGCGGTGgcacaacgacgacaacaacaacagtcaatGCTGAGGCAGCGAGCatacatcaacagcagcaacatcagcagcagcgcaatgGAGTCGCTGGCAAGACGACTGATATCACACATTACTACAAGGTCAAGCGAAGGCCTCACGCAGCCACCCACGAGATCCACCCCAAGAAACAGGCCAAGCAGAGCGCACAGCATCAAACGGtcacctacaacaacaacagcaacagtaaacAGAcggcccaacagcagcagcagcagcgcttccatcaacagcagcagcatcagcaatacGACGTCGTCGAGCACGACGAAGACGATGATGTGGAGACGAGCAAACCGAGCGGCAACAACGTTTCCTCATCGCATTCGCATGCACACATCGTGAGGACAGCgtcgcatcagcagcagcagcaaacgacgtcgcagcaacagcagacagcGCTAGTGACTTCGTCATCGGCCTCAACTGgaagcggcggcggcggtacCGGCAGTAGCAATGGCGGTGATCGCAATCGAGCGGACACCTCGCTGGGCATTTTGACCAAAAAGTTTGTGGATCTGCTGCAGGAATCGCCGGATGGTGTTGTCGATCTGAACGATGCGTCGATACGACTATCCGTGCAGAAACGTCGCATCTACGACATTACGAACGTGCTCGAGGGCATCGGCATCTTGGAGAAGAAATCCAAGAACAACATTCAATGGCGCGGCGGTCAATCGCTGGTCAGCAGCGAACGGTCCCGCCACATCGAGGCGGAGAGCGAGCGGCTGGAGCAGCGGGAGAATGAGCTCAACACCCTAATCGATCAGATGCGGGGCGAGCTGGCCGAGATATCGCAGGAGGTGGAGAATAGCGGTGGCAAGGCCTATGTGACGCAGAATGATCTGCTCAATGTGGACCTGTTCAAGGATCAGATTGTGATTGTGATCAAGGCGCCTCCAGAGGCCAAACTAGTGCTGCCCAACACAAAACTACCGCGCGAGATCTACGTGAAAGCGGAGAATAGCGGGGAGATCAATGTCTTTTTGTGCCACGACAATTCACCGGAGAATTCGCCAATTGCGACGGGTTCCAGTTATGCGGGCGGTGTCCACAGCGGCATACGCACAGCGACATCGAAGCGACTGCATCACATGACCAATCAGCACATCGATCCCCTATTCGATAACATTGATGCCATGAGCACCAGAGGTTTAGGCCCTCCACCATATCGCTTATCGGCGCAGCGTAACCTCAGTAAGTCGATTGAGGAAGCGGCCAAGCAATCCCAGCCTGAATATAATAACATTTGTGATATTGGCGGCGTCAAATATGAAGTGACctcgccacagcagcagcagctgcagcgcgGTTCGACGCATGCAGATGATAATAAGGATggtaataatgatgatgatgatgttgacgacgacgtcgacgatgAGCTGAGTCAGCTCAGTCAGGTGCCGACGCTAATCAGTCCCGTGGTGCGCGGCAGTGTTCATCATCAGCGGCAGCAGAACGTCGCTATTCAGAAAATTATTAACAGCCTAACACAATCCCCGCCAACGCCGCGCATCTGGCGGCGTGCGGCGAATTCAGCTGCCAACAATTCCGCCGCGGGCAACACAACTACGCTTAATAGtcataacagcagcagcagcaacaatagcaacagcaacaacaacaattcccAATCccacagcaatagcagcacagtaaattacaacaacaacaatcagcaacagcagcggcgcaGCGATGTGCCCATGTATAACTGTGCAATGGACGACGCGACTGCAACGTATGCTGTTAACAATAACAgtagcagaaacaacaacagcagcggcagccactCGTCCGCAGTAAGCTCGCTGCAAATGCAGTTTGCAGCAGTGGCTGGAAATGAGAGCAACAGCGGGCTTGGCGTTGGCTTGGCGGCAACATATGGCGACATCTCTGGCGCTGGCGCCAATgttgatcagcagcagcagcagatgcagcagcaatacaacaacaagaatagtTATCGCAATCTGCCGCCAGGCGGCGCCGACTGTGACGCCGACAGCGACGGCAGCACTGTTGTTCTCCAAGGCCTCGATGCGCTGTTCAGCGATATCGACACGGACTACTTCAGTAACGAGCCGTTTGTCTCCATCGATCCACCGGATGACAACGATTATCCTTATGCTCTCAACGCCAACGAGGGCATTGATCGTCTCTTTGACTTTAGCTCCGATGCCTATGGGCCCTAA
Protein Sequence
MSKFFITAAPNSNNNNNNSNTQRQQQIYGGATQVVRKLSYDPLGTNNNNNYNNNIVIKNEKLLEIDYEHSGGNDNSSSNNNNNNNGSGVAAHLRDHVYISLNKGGGTTTTTTTVNAEAASIHQQQQHQQQRNGVAGKTTDITHYYKVKRRPHAATHEIHPKKQAKQSAQHQTVTYNNNSNSKQTAQQQQQQRFHQQQQHQQYDVVEHDEDDDVETSKPSGNNVSSSHSHAHIVRTASHQQQQQTTSQQQQTALVTSSSASTGSGGGGTGSSNGGDRNRADTSLGILTKKFVDLLQESPDGVVDLNDASIRLSVQKRRIYDITNVLEGIGILEKKSKNNIQWRGGQSLVSSERSRHIEAESERLEQRENELNTLIDQMRGELAEISQEVENSGGKAYVTQNDLLNVDLFKDQIVIVIKAPPEAKLVLPNTKLPREIYVKAENSGEINVFLCHDNSPENSPIATGSSYAGGVHSGIRTATSKRLHHMTNQHIDPLFDNIDAMSTRGLGPPPYRLSAQRNLSKSIEEAAKQSQPEYNNICDIGGVKYEVTSPQQQQLQRGSTHADDNKDGNNDDDDVDDDVDDELSQLSQVPTLISPVVRGSVHHQRQQNVAIQKIINSLTQSPPTPRIWRRAANSAANNSAAGNTTTLNSHNSSSSNNSNSNNNNSQSHSNSSTVNYNNNNQQQQRRSDVPMYNCAMDDATATYAVNNNSSRNNNSSGSHSSAVSSLQMQFAAVAGNESNSGLGVGLAATYGDISGAGANVDQQQQQMQQQYNNKNSYRNLPPGGADCDADSDGSTVVLQGLDALFSDIDTDYFSNEPFVSIDPPDDNDYPYALNANEGIDRLFDFSSDAYGP