Dcog004849.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila cognata
Gene Symbol
hang
Assembly
GCA_035041535.1
Location
JAWNLC010000235.1:10473335-10489426[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.65 41 4.9 3.6 3 22 644 663 642 663 0.89
2 17 0.00084 0.053 14.0 3.3 1 22 783 804 783 806 0.90
3 17 0.096 6.1 7.5 0.1 2 21 818 837 817 838 0.93
4 17 0.00097 0.062 13.8 0.2 2 23 935 957 934 957 0.95
5 17 0.0036 0.23 12.0 0.2 1 23 965 988 965 988 0.96
6 17 0.00021 0.014 15.9 0.2 2 23 1080 1101 1079 1101 0.97
7 17 0.0004 0.026 15.0 2.9 2 23 1238 1260 1237 1260 0.97
8 17 0.031 2 9.0 0.2 2 23 1269 1291 1268 1291 0.95
9 17 0.0019 0.12 12.9 0.3 1 23 1304 1327 1304 1327 0.97
10 17 0.00017 0.011 16.1 1.1 1 23 1382 1404 1382 1404 0.99
11 17 0.0027 0.17 12.4 0.9 1 23 1412 1435 1412 1435 0.96
12 17 0.069 4.4 8.0 0.3 2 19 1443 1460 1442 1461 0.94
13 17 3.7e-05 0.0023 18.3 0.4 3 23 1559 1579 1558 1579 0.98
14 17 0.00058 0.037 14.5 0.1 1 23 1614 1636 1614 1636 0.97
15 17 0.0021 0.14 12.7 0.5 2 23 1730 1752 1729 1752 0.92
16 17 0.0092 0.59 10.7 0.4 3 23 1808 1828 1808 1828 0.98
17 17 0.0054 0.34 11.4 1.8 1 23 2256 2278 2256 2278 0.99

Sequence Information

Coding Sequence
ATGTGCGACggtgccacaacaacaacaactgcagcagcagtaacaacaacaactgcatcagcagcacaaGGAACAGGAGCAGCTGGTGATAATGCGATGGAAGAACAAAATCAGAGAGAGCGACAAAGCTGCTGTCGCCTGTGCATTGCGCCCGCCAGCGAATGCATTTCGATCATCAACAGTTATGCGGCCGATAAGGAGCCGTTGGCcactaaaatacaaaactgcGTAAATATCAAGATCACATCGGCGGATCGCCTATCGTTGCATATTTGCCATGCCTGCATCAGTTATTTGAACTCGTGGCAGAGCTTCAAGAATCGCTGCTTCAGTTCACAGTGGAAGCAGCGCCAGTGGCAGGAGAGCGACAAAACCAAGCAGCAGATGCTACTCGGATACTTGGATTTGAACAGGGCCGAGAATGGCAACACcattgaacaacaacaacaacagcagcacgaaTTGAAATTGGATTCAACGACGGCTGCAGCTGAAAAGGCGTCCGCTGCCAACATTTTGGATGGCATACCTCAGCTGAAGAAACGCAAATCGTTAACAGTCTATGTGAGtccaaagcaacagcagcaagcacagcaacaacagtcgcagcaacattcgcagcaacagcatgcaACAGGGGCAAGATCAACAACGAAAACatcgacggcggcggcggcggtggcggagTCGCAACCAACATTGCAAACCCTTTTATTGCAGGtgcccacagcagcagcagcagcagcgacattGGCAACGGCGtcaacacagcaacagcagcgcaagcatcaacagcagcaacaccatcagcagcagcagcagcaacgtggcaagcagccgcaacatcagtaccatcaacagcaacagcagcatcgacAGAGTCGCGTTCGTCAACCGCGGCGACAGCAACAAGCGGCAACGGCCAAATTCAGgagcaaattatttatgccaCTGGATATATCGGTGCCAGCGCTGCCAGCGCTGTTGCCACCGCCGACGccagctgttgctgatgcagcGTCGTTGCTAttgccgctgtcgctgccacTTGATTTTAGCCAGAATCCGAATCTGAATCCAAATCCCAATCAgtatccaaatccaaatccaaatcaaaacTTAAATCAGAGATATACAAGTAGCCTTTTagtgccgccgccgctgccactgTCCGCGCCAGTTGCAACAATGAGCAGCAACGAGGCTGCCATTGCCACTGGCTGtggtgcaactgcaactgcaactgcaaccgcaACCGCAGTCACGACTCCATTGCTCATGCCGCCGGTGCCTGCCGTGCCCATCAAGGATGAGCCCCTGTACGACACGGATGATGACTTTCAAATGAGGTCCATAGACGAATCCGATGATATGATGGATCCCACAATGTTCCTAGAGCGCTCCGAGCACGAAGGCGATGTGCCACTAAATACCTCTGACTATGATTATACGGCTCAGCATGGCGTGACCGCGGCTGTGGCGGCGGCATCGCTGCCCGCCAGCGCTGTGGCAAATGTGGCAGCCGCTGGGGACTCGAAGGTGGCCAGCTGCCGGGCGTGCAGTCTGCAGTTGACGCGGGCCAACGCTCGTCGCCACGAGCGCAATCTGCACCCCAATCTGTTCCAATTGTCGACAGACTCACCAAATAATACGCCGATTACAAAACCAACGCCGGCCCTCGCCGCCGCCTTGGAGATACAGCgcgcagcggcggcggcaaccgCAACCGCTGAGGCAACCCGTGCCGCTGCCGGCGGCAATATATCGGCCCAAAAATATCGACAGGTGGTGATGAACACGTTCACCAAATGCGAGAACGGCGGCTTCGACTACGACAATCCCGAACAGTATCAGCAGCTGTTGTCGCACGACAAGGTCGACTTCATCCAGGAGAACACCGAATTTCTCGAACAGTACCAGACGATGACGTGTCGCTGTTGCAACAAGTTCTTCAACACGTACAAGAACTTCATGGCGCACGTGCGCAAAAAGTATCCGTTGCTGCCACGCAACCTGTGCTTCAATTGCCTCAAGATGAACGACTCGAAGGCGCTGTTCATATCACATCTGAAGAAGCGCAACTGCATCAATTTGTATCGAGTGCTTAACGCACTGCGCACCAAACAGCCAAACTTTGTCCATGCCAATGCTGCCTCATCCAGTGCACCCACATCAGCGAACGCTCtaaaccagcagcagcaacagttagTGAAAGCAAACGAAACAGGAGcagaaactacaacaacttcaacaacaacaacaccatcaacaacaacaacaccatcaacaccaTCTACGGATCGTACGGAGAAGTTGCGTGCTAAGGATCTGCTGGTTAACAAGCTCTACGAGTGCAAGCTGTGCCCAAAGGGTTTCCGCACAAAGCACGAGTTCCGCACCCATGTCTATGATAAGCATGCGGATGTGCAGCGCAAAGATAACAATTCGATACAGTGCAGCTTCTGTGGCCTGGACTTTGCCGATCCGGTGGATCGTCGAAGGCATTACAATAACATGGATTGCATTGTGCGGCTGCGCTGCATGACCTGCGATGCCAAACTGGAGACGCATCAGCGCTTCCTCGAACATGTCTATCAGGATCATTTGGGTGGCGTGAGCAGTGATAATGCGTCCCAGCGCAGTTTGCTGGGCTCCCTTGGCATCGTTGGCGCCAATCAATCACCCAACGACGAGtcgcgcagcagcaacagcaacaataatcacaacaataacaacaataataatactaataacaacaacaacaataatccaCCTTCGCAGTATTTCTCACGCATGCCACAGGTCTGTCCGATCTGTGGCCAGCAGTACAATAACTATAACAATGTGTTGCGCCACATGGAATCGAAGCATCCCAACAAATTGCCCGAGACATACAAGTGTGTGCGTTGTGGACTGGGCTATCCGCGCATCTCCTATCTGCGGGAGCACATGACCAATGTGCATGGCGTCGATAAGAATCGCCAGACGGGCGGATTTGAGTATATTGTGAATGCCGATGCGGTTAAATTGGCGGATGGCAGCACGCCCAATGTCTATACGGGACGATATGATTATGTGATGAAGGATCTTATGTCTATAACAAATGGTGGGACACTcgatgatgatgacgacgatggcgGCGACAGCGTTGGCCCCCCTGCCAAGAAGATGCGAAACAATGatagcagcaccaccagcagcagcatcaacatgaGCAGCATTGCCAACCAGCAGAAGGAGTGCCTCATCTGCAATGCGGTGTTCAGCAACAATATTGGTCTATCGAATCATATGCGTTCCCATTACACAGCATCAATAACGACAAGTGCTGCTCTGGCGGCTGCCAATCGCATGACGCCCAAATCGCTGACAATAACAGCAACGCCACCGCTCGAGGTGACAGccacgtcgacgtcgacgtcggcaACATCATCGTTAGCGACGGGCACAACAAATACATCAATTGcggctgcggttgctgctgcaacaaagacaacaacaactgtggctGGAgttgcagcagtggcagcattATTTGCTTCTTCCTCATCGGGAGCAGCCGCCCCAACAGGCACAGgaacagcatcaacatcaacatcagcatcatcatccgGCAACTTGCCGCCAGCAATGGTGCATCAGACGGCCCAGGAGCAGGCGGTATTCCGTCGGAGTCTGGATCAGGCGGCCGATCGACGATTCCGTCGAATGCGCTGTCGCATCTGCCAGCGGAGATTCAGTTCGAAGAAGTCGTATCGCTACCACATGCTAACCGACCATCAGGTGCAGAATGTGCAGTTCATCAAGTGCAAGCTGTGCAACGCGGAGTTCGCCTACGAGAAGGGATTGAAGGTGCATCTGTTCAAGGTGCACGGTCGGGCCATCAAGGATGAGATGATTATCAAGCAGTTCGAGTGCGATGTCTGCTCCACTGTTTACAGCTCCGAACTGGaattgcagcagcacaagcgCAGCGTACACAAGTCACAAGCCACCACCgattcatcatcatcatctgcagcAGCCGGTGGCAAACAATCATCAAATAAgtcagcgactgcgactgcaaccGCTACCTCCACAGCGGCGGAACTGGCGGCAGACACATCATCAGGGGCGGCCACGCAGCTGCCACTCTACTGGTACCAGTGCAAATATTGTCCATCCAACTTCAACACCAACAAGAAACTGGCCATCCACATCAACTCGCACGACGAGTTCGACTCGAATGATTACTCGTGCAAGGACTGTGGCAATGTCTACAGCGGCCGCAAGAGCCTCTGGgTGCATCGCTACAAGAAGCATCCGCAGGTGCCGGATCCCGTCGAGTGCACGCTGTGCCGCAAGATGTTCTTCGATCGCCAGATGCTGGAGAATCATACGCCCACCTGCAATCGCAAGCCAATCACTGCCACCGGCGCCCATCAGcaggatcagcagcagcagcaacaacagcaacaacagcaacaacaacagatgcagcagcaatacCATCAGCGAGTCATCTTCAAGCATAAAAcgggtgatgatgatgacgaggatgaggacgatgatcAGTTGCAGTTAATGGACGATGGCGGTGGCGGCAGCACTGATAGCAATGCTGGCAATGCcattgcaacagctgcagcagcagcggcgagcTCAATAAAGATACGCATTCCGGAGGTGGCATGCACTATTTGCGGTGCCCGGTTCACCGATCAGGAGATGTTTACCAAGCACATACAGAAGCACGAACAGGAACTGTATGTGGACAATCCGTTGGCGGCTATGTTCGATGATGGGCCAGCGGATGCCGGACAATTTCAGATTGATCACCAGAACGAGAATGGCGAATACGCGTGCGATTTGTGCAACAAGACGTTCCCCCAGGTGATTGCGCTCAAGGTGCATCGCAAGTGGCATTTCAGAGGTGATAGCAAGCAGATGCCACTCAACGACGGCGAAGCGACAACgctgaacaacagcagcaacaacagcagcagcagcaacaacaacaacaacaacaacaacaattcgctCAGCTCATCATCGATGCTGCATCTACGCGAACTGCATGCAGTGGGTCTGATGcccaatcagcagcaacaccagaaacaggaacaacagcagcagcaggaacaacatcaacagcagcagcagcaacaacggacGAGCAAATCATTGAAACGGAAACGTGAACTGAACTGCGAATACTGCGCCTCCACAttcattagcaacaacaacctgcGACGCCACATGTACGAGCTGCACAAGAACGAGGTGAGCAATCTGCCAGAGCCGCCCGCGATTGAGGTGGATGAGCCGTTGACGTGTCGCCGCTGCGGCGATCTGATGTTTGAGACCAAAGAGCAATGGATCGAGCATAAGCTGGCCGATGCGAGGGTGGTGCGTCCATTCTGTCCATTCCAATGGGGCTGTGATCTGTGCGGCGAATATTTGTCGCGCAAGGAGAAGCTCATGAATCACATTAACAATCATCTCAAGGAGGATGTGATTGTGCCGGTCGCCACCAAGTCAACAGCAATGACACCCAATAATGTTgcgacggcaacagcagcaacagttttaGCTGCTACATCACCAGTAGCTGCAGTATCAGAAGCCGCAGCAGAGGCGGCGAAGGTAAAaaagtcaacagcagcaaaagaactTAAGTCTAAACATCAGCTGGATAATGTGAAGCGAacgaagcaacagcagcaagagaaTGCGGAAAATGTTGATAGTGATATGGATGATGATAGCAATAGTGGcaatgatgatgaggagggCGAGGGCAGCACCAGTgctgacgacgatgacgaggacgaggatgatgatgaggagggcgacgtcgacgacgatgatgaagatgatgacgaGAGCGACGTCGACGAAGATGatgatttgaaaaatgttattgaaCTGAAAATGCTGCATATACTGCCGGAAAatacaaacaccaacaacgacgacgacgaagatgatgacgatgataatGACAAAAATCTTCTTAAACTGAAAATTCTGAAACAAATGCCGCAAAATACAAACACCAAATACGACAACGACGACCCTATTCTTAAAGACATCGATGTCATTGAGTTGGAACTCGTGTCAGCatccgatgatgatgatgatgatgatgatgatgatgatgatgatgatgatgatgatgatggcgaagACGAAGACAATGATGATGGCGAAGACGaagacaatgatgatgatgacgatggcgaagacgatgacgatggcgatggcgatggcgatatcgatgacgatgacgataaTAATGCAACGGTTGAGCAGCTGAGGCCCCTCAATTTCGACTATTCGTGCGCCGACAGGGCCAAGCTAAATGGCAACGCTGGCGAACAGTCTGTGGCAAAATCAAAGAAACGGATACAACAAATgctgggcaacagcagcagtcgccgcGGGGATGATGGCGAGGAGGAAGTGGATGATatagatgatgatgatgatgttgtgggTGAAGCGATGTCCATTGATGATATTATTGTGGAGGATGATGGTGTGGATGATGACGAAGTGGTTGGTGTcggtggtggtgttgttgaggatgatgatgaagatgatgaagaACATGGcgatgatggcgatgatgagGATGTTGGTACATCATCATCTGAGAGCGagtcgacaacaacagcatcgaGTTCAACTGGTGAGCGgcgtaataaaaaaaataaaaataaaaataaagtagtTGCATCAGCGGCACATGGCGCTGCCGCTGATCAGTCTAATTCCATCTATACGTGTGATCTATGTCAACTTTGTTTCGATTCCCAGGAGATACTTCAGACTCACATTAAAAGTCATTTCCTCAATGGGCCATCGGcggggagcagcagcaacagcaacagcaacaagagcaacggcggcagcaggagcaccaataacaacagcaacaacaacagtagtagtagttgcagcaacagcaataacaaaatcaatacCAAAAAGTCCGACTTGAATGCAACGacgaagacaacaacagcaacaactgttaaAGATGTAGCAACGGACGCTGCAACGGGCTTCAACTGA
Protein Sequence
MCDGATTTTTAAAVTTTTASAAQGTGAAGDNAMEEQNQRERQSCCRLCIAPASECISIINSYAADKEPLATKIQNCVNIKITSADRLSLHICHACISYLNSWQSFKNRCFSSQWKQRQWQESDKTKQQMLLGYLDLNRAENGNTIEQQQQQQHELKLDSTTAAAEKASAANILDGIPQLKKRKSLTVYVSPKQQQQAQQQQSQQHSQQQHATGARSTTKTSTAAAAVAESQPTLQTLLLQVPTAAAAAATLATASTQQQQRKHQQQQHHQQQQQQRGKQPQHQYHQQQQQHRQSRVRQPRRQQQAATAKFRSKLFMPLDISVPALPALLPPPTPAVADAASLLLPLSLPLDFSQNPNLNPNPNQYPNPNPNQNLNQRYTSSLLVPPPLPLSAPVATMSSNEAAIATGCGATATATATATAVTTPLLMPPVPAVPIKDEPLYDTDDDFQMRSIDESDDMMDPTMFLERSEHEGDVPLNTSDYDYTAQHGVTAAVAAASLPASAVANVAAAGDSKVASCRACSLQLTRANARRHERNLHPNLFQLSTDSPNNTPITKPTPALAAALEIQRAAAAATATAEATRAAAGGNISAQKYRQVVMNTFTKCENGGFDYDNPEQYQQLLSHDKVDFIQENTEFLEQYQTMTCRCCNKFFNTYKNFMAHVRKKYPLLPRNLCFNCLKMNDSKALFISHLKKRNCINLYRVLNALRTKQPNFVHANAASSSAPTSANALNQQQQQLVKANETGAETTTTSTTTTPSTTTTPSTPSTDRTEKLRAKDLLVNKLYECKLCPKGFRTKHEFRTHVYDKHADVQRKDNNSIQCSFCGLDFADPVDRRRHYNNMDCIVRLRCMTCDAKLETHQRFLEHVYQDHLGGVSSDNASQRSLLGSLGIVGANQSPNDESRSSNSNNNHNNNNNNNTNNNNNNNPPSQYFSRMPQVCPICGQQYNNYNNVLRHMESKHPNKLPETYKCVRCGLGYPRISYLREHMTNVHGVDKNRQTGGFEYIVNADAVKLADGSTPNVYTGRYDYVMKDLMSITNGGTLDDDDDDGGDSVGPPAKKMRNNDSSTTSSSINMSSIANQQKECLICNAVFSNNIGLSNHMRSHYTASITTSAALAAANRMTPKSLTITATPPLEVTATSTSTSATSSLATGTTNTSIAAAVAAATKTTTTVAGVAAVAALFASSSSGAAAPTGTGTASTSTSASSSGNLPPAMVHQTAQEQAVFRRSLDQAADRRFRRMRCRICQRRFSSKKSYRYHMLTDHQVQNVQFIKCKLCNAEFAYEKGLKVHLFKVHGRAIKDEMIIKQFECDVCSTVYSSELELQQHKRSVHKSQATTDSSSSSAAAGGKQSSNKSATATATATSTAAELAADTSSGAATQLPLYWYQCKYCPSNFNTNKKLAIHINSHDEFDSNDYSCKDCGNVYSGRKSLWVHRYKKHPQVPDPVECTLCRKMFFDRQMLENHTPTCNRKPITATGAHQQDQQQQQQQQQQQQQQMQQQYHQRVIFKHKTGDDDDEDEDDDQLQLMDDGGGGSTDSNAGNAIATAAAAAASSIKIRIPEVACTICGARFTDQEMFTKHIQKHEQELYVDNPLAAMFDDGPADAGQFQIDHQNENGEYACDLCNKTFPQVIALKVHRKWHFRGDSKQMPLNDGEATTLNNSSNNSSSSNNNNNNNNNSLSSSSMLHLRELHAVGLMPNQQQHQKQEQQQQQEQHQQQQQQQRTSKSLKRKRELNCEYCASTFISNNNLRRHMYELHKNEVSNLPEPPAIEVDEPLTCRRCGDLMFETKEQWIEHKLADARVVRPFCPFQWGCDLCGEYLSRKEKLMNHINNHLKEDVIVPVATKSTAMTPNNVATATAATVLAATSPVAAVSEAAAEAAKVKKSTAAKELKSKHQLDNVKRTKQQQQENAENVDSDMDDDSNSGNDDEEGEGSTSADDDDEDEDDDEEGDVDDDDEDDDESDVDEDDDLKNVIELKMLHILPENTNTNNDDDEDDDDDNDKNLLKLKILKQMPQNTNTKYDNDDPILKDIDVIELELVSASDDDDDDDDDDDDDDDDDDGEDEDNDDGEDEDNDDDDDGEDDDDGDGDGDIDDDDDNNATVEQLRPLNFDYSCADRAKLNGNAGEQSVAKSKKRIQQMLGNSSSRRGDDGEEEVDDIDDDDDVVGEAMSIDDIIVEDDGVDDDEVVGVGGGVVEDDDEDDEEHGDDGDDEDVGTSSSESESTTTASSSTGERRNKKNKNKNKVVASAAHGAAADQSNSIYTCDLCQLCFDSQEILQTHIKSHFLNGPSAGSSSNSNSNKSNGGSRSTNNNSNNNSSSSCSNSNNKINTKKSDLNATTKTTTATTVKDVATDAATGFN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00496779;
90% Identity
iTF_00620008;
80% Identity
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