Basic Information

Gene Symbol
Hr39
Assembly
GCA_011750605.1
Location
NC:11510172-11536399[+]

Transcription Factor Domain

TF Family
SF-like
Domain
zf-C4|SF-like
PFAM
AnimalTFDB
TF Group
Zinc-Coordinating Group
Description
The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 0.97 6e+03 -4.3 4.9 115 189 116 186 24 206 0.41
2 4 2 1.2e+04 -9.1 14.5 45 157 188 306 157 328 0.36
3 4 1e-24 6.3e-21 74.7 3.3 1 160 465 641 465 644 0.84
4 4 7.6e-84 4.7e-80 269.5 0.9 182 408 623 840 618 840 0.96

Sequence Information

Coding Sequence
ATGTCCAGCATCAAGACGGAGCAGAGCGCAGCAGCGGGCGGAGCCAACAGCATTGGCTATCAGCTGCCTATGAACATGAgcacagcgacagcagctacgacgacgacgatgggAGCGTCTGTGGCATCCACTGTGCGTCACAATGTGTCGGTGACCAATATCAAGTGCGAGCTGGATGAGCTGCCGACGCCGAATGGGAATTTGGTGCCGGTTATAGCGAGCTATAACAATCATAATCACAATCACAATCACGGCAATAGTTTGCGCATACCGCTGAGCGGCACGAGCACGGGCCAGGCGGAGGAGGAGTCCGACTCGGAGGCGGAGCTGGCGAACATTGAGAGTCTGAAGGTGCGACGACGAGCGGCGGACAAGAATGGACCGCGGCCCATGAGCTGGGAGGGTGAGCTCAGCGAGCCAGAGACCAATTTGGGCGATGAGGAGCTCATGGAAACGGAAACGGTTATCAAAAGcgaagccagcagcagcacaagcagcagtcAAGTGGTGGCCATGATGCAGCCCATCAAAACCGAGCTGGAGCATATAGCGGgcgaaatgcagcagcagcaaccacaacagcaacatcagcagcagcaacagttgctgccgctaaagcaaaactttggcAACAAACTGAAGCTGGCGCCGACGCAAAGTGATCCCATTAATCTCAAATACGAACCCGCCGTTGCCAGCTCAACGCTGTGCGAGCGCAGCAAATCCTCAAGCGGCGGTcatttgccgctgctgcccgCCAATCCCAGTCCCGACTCGGCCATACATTCCGTTTATACGCACAGTAGTCCGTCGCAGTCGCCGCTAACGTCGCGCCACGCCCCCTATACGCCCTCGCTGagccgcaacaacagcgacgcatcgcacagcagctgctacagctacagctccgAGTTCAGTCCCACCCACTCGCCCATACAGGCGCGTCATGCGCCCTATCCCGGCACAGTGCCCActggcgccgccgccagctATGCCAATGGCGCAACGCCGCTGCATCATCATAGTCTGCTCTATCGGCCATTGAATGtggacgctgctgctgccgccgccgccgccgggCAGGAGGCACAAAATCTCAGCATGGATGCCAGCAATTTGGATGCCACTGCCGCGCTGCCTGCTTCACCGGCGGGCATCTCACGCCAGCAGCTGATCAACTCGCCCTGTCCCATTTGCGGCGACAAGATCAGCGGCTTCCATTACGGCATCTTCAGCTGCGAGAGCTGCAAGGGATTCTTCAAGCGCACCGTGCAGAATCGCAAGaactatgtgtgcgtgcgtggtGGGCCCTGCCAGGTGAGCATCTCCACGCGCAAAAAGTGCCCCGCCTGCCGTTTTGAGAAGTGTCTGCAAAAGGGCATGAAACTGGAGGCCATACGCGAGGATCGCACACGCGGCGGTCGTTCCACCTATCAATGCTCCTATACGCTGCCCAATGCCATGTTGAGTCCACTGCTAAGTCCAGAtcaggcggcagcagcagcagcagccgcagcagcgcaacagcaacaacaccaacaacagcagcagcagcagcaacatcagcagcagcaacaacaacagcagagattgcagcatcaacagcagctcaaTGGCTTTaacagtggcggcggcggcggtggctcCAGCTGCGGCAGCTTGCCCGCCAGTCCCAGTCTGGGCGCTGCCATCAAGACTGAGCAAACCGAAGCGCAGCTTCTAACACGCGCCTCCAGCGTTCCAGCTCTGCTACAGGAAATCATGGATGTTGAACATCTCTGGCAATACACGGATGCAGAGCTGGCGCGCATTAATCAGCCGCTGTCCTCATTTGGTGCAAATggtgccagcaacagcagcagcagcagcgaaccaCAGATGACCAATCCACTGCTGGCCAGTGCTGGTCTCTCATCCAATGGCGAGAATGCCAATCCCGATCTGATTGCTCATCTCTGTAATGTCGCCGATCATCGGCTCTATAAGATTGTCAAATGGTGCAAGAGTCTGCCGCTCTTTAAGAATATATCGATTGACGATCAAATCTGCCTGCTCATCAACTCCTGGTGCGAACTGTTGCTGTTCTCCTGCTGTTTTCGTTCGATTGATACGCCCGGCGAGATTAAAATGTCACAGGGCAGAAAGATTACGCTGGCGCAGGCTAAGACCAATGGCTTGCAGgcCTGCATTGAACGTATGTTGAATCTGACAGATCATTTGCGGCGTTTACGCGTTGATCGCTATGAATATGTTGCCATGAAGGTGATCGTGCTGCTGCAGTCTGACACCACAGAGCTGCATGAGGCGGTTAAGGTGCGCGAGTGCCAGGAGAAGGCGCTGCAGAGCTTACAGGCCTATACGCTGGCCCATTATCCCGATACGCCGTCCAAGTTTGgtgaactgctgctgcgcattccCGATCTACAGCGCACGTGTCAGCTGGGCAAGGAGATGCTCACCATAAAGACACGTGATGGCGCTGACTTCAATTTGCTGATGGAGCTGCTGCGCGGAGAACATTGA
Protein Sequence
MSSIKTEQSAAAGGANSIGYQLPMNMSTATAATTTTMGASVASTVRHNVSVTNIKCELDELPTPNGNLVPVIASYNNHNHNHNHGNSLRIPLSGTSTGQAEEESDSEAELANIESLKVRRRAADKNGPRPMSWEGELSEPETNLGDEELMETETVIKSEASSSTSSSQVVAMMQPIKTELEHIAGEMQQQQPQQQHQQQQQLLPLKQNFGNKLKLAPTQSDPINLKYEPAVASSTLCERSKSSSGGHLPLLPANPSPDSAIHSVYTHSSPSQSPLTSRHAPYTPSLSRNNSDASHSSCYSYSSEFSPTHSPIQARHAPYPGTVPTGAAASYANGATPLHHHSLLYRPLNVDAAAAAAAAGQEAQNLSMDASNLDATAALPASPAGISRQQLINSPCPICGDKISGFHYGIFSCESCKGFFKRTVQNRKNYVCVRGGPCQVSISTRKKCPACRFEKCLQKGMKLEAIREDRTRGGRSTYQCSYTLPNAMLSPLLSPDQAAAAAAAAAAQQQQHQQQQQQQQHQQQQQQQQRLQHQQQLNGFNSGGGGGGSSCGSLPASPSLGAAIKTEQTEAQLLTRASSVPALLQEIMDVEHLWQYTDAELARINQPLSSFGANGASNSSSSSEPQMTNPLLASAGLSSNGENANPDLIAHLCNVADHRLYKIVKWCKSLPLFKNISIDDQICLLINSWCELLLFSCCFRSIDTPGEIKMSQGRKITLAQAKTNGLQACIERMLNLTDHLRRLRVDRYEYVAMKVIVLLQSDTTELHEAVKVRECQEKALQSLQAYTLAHYPDTPSKFGELLLRIPDLQRTCQLGKEMLTIKTRDGADFNLLMELLRGEH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00575636;
90% Identity
iTF_00493003;
80% Identity
iTF_00493003;