Basic Information

Insect: Drosophila borealis
Gene Symbol: zfh1
Assembly: GCA_035045885.1
Location: JAWNOR010000194.1:11749226-11753402[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 3.9e-05 0.0031 18.2 1.1 1 23 150 172 150 172 0.97

2 15 0.00091 0.074 13.8 1.2 3 23 180 200 178 200 0.94

3 15 9.9e-05 0.0081 16.9 0.1 1 23 355 377 355 377 0.98

4 15 0.00034 0.028 15.2 0.9 1 23 383 405 383 405 0.98

5 15 3.8e-05 0.0031 18.2 2.2 1 23 436 459 436 459 0.95

6 15 0.00062 0.051 14.4 1.9 1 23 497 519 497 519 0.95

7 15 0.019 1.6 9.7 1.3 1 23 525 548 525 548 0.97

8 15 0.029 2.4 9.1 0.4 3 19 557 573 556 574 0.95

9 15 0.00017 0.014 16.1 5.6 1 23 583 605 583 605 0.97

10 15 0.045 3.6 8.5 1.2 2 23 611 632 610 632 0.96

11 15 1e-05 0.00082 20.0 1.0 1 23 641 663 641 663 0.98

12 15 0.0011 0.093 13.5 0.1 3 23 671 691 669 691 0.97

13 15 6.1e-05 0.005 17.5 0.5 1 23 697 719 697 720 0.95

14 15 0.058 4.7 8.2 0.4 1 23 730 752 730 752 0.97

15 15 0.0017 0.14 13.0 0.3 1 23 1286 1308 1286 1308 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	3.9e-05	0.0031	18.2	1.1	1	23	150	172	150	172	0.97
2	15	0.00091	0.074	13.8	1.2	3	23	180	200	178	200	0.94
3	15	9.9e-05	0.0081	16.9	0.1	1	23	355	377	355	377	0.98
4	15	0.00034	0.028	15.2	0.9	1	23	383	405	383	405	0.98
5	15	3.8e-05	0.0031	18.2	2.2	1	23	436	459	436	459	0.95
6	15	0.00062	0.051	14.4	1.9	1	23	497	519	497	519	0.95
7	15	0.019	1.6	9.7	1.3	1	23	525	548	525	548	0.97
8	15	0.029	2.4	9.1	0.4	3	19	557	573	556	574	0.95
9	15	0.00017	0.014	16.1	5.6	1	23	583	605	583	605	0.97
10	15	0.045	3.6	8.5	1.2	2	23	611	632	610	632	0.96
11	15	1e-05	0.00082	20.0	1.0	1	23	641	663	641	663	0.98
12	15	0.0011	0.093	13.5	0.1	3	23	671	691	669	691	0.97
13	15	6.1e-05	0.005	17.5	0.5	1	23	697	719	697	720	0.95
14	15	0.058	4.7	8.2	0.4	1	23	730	752	730	752	0.97
15	15	0.0017	0.14	13.0	0.3	1	23	1286	1308	1286	1308	0.98

Sequence Information

Coding Sequence: ATGAACAATCAGGACTATGGCGGCATCCAATGGATACAGCAGCACGCATCTGCGGTTGATTCCGAAACAGATATGCTGGAAAACGGCGCTGCTGACAGCGAGGTGACTGCCGCCTATTTGGTAAATGGCAATGCAACAGACGAGGATCTTGACCATATGGCGGCCGAGAATCTTATCTTCATGGCGCGCGATGGTCAGCTAAGCGAAATCATAGCCGCCAACGAAGCCGGCGGCGGAACTGTATTAATCACGGACAGCGGCACCGTTGCCTATGCCGAGTCATTTGATGATGATGCACAGGTGGTCACCGAGGAGATCATTACCGATGATTGGGTGCAGCATCAGGGTGCCGAGCGCGTGGAAATCGCCGCAGAGCAAATAGCGGGCAACAATAGCTCGCAGGAGCTGCTGGACATGGAGCAGGATGAATATACGGCACTGCGCCCCTATCCCTGCGACTTTTGTAGCCGACGCTTTCGCAAAAAGGGCAGCCTCAATACTCACATGCTGGCGCACCAAAACGATCGTCCACATCTGTGTAAATTGTGCGGCGCACGTTTTTCAAGGCGCGCTGAGCTCATCAGTCACTTCAAGGCGCATGCCGAGGCACAGGTTGCGGCAGATGAGGCGGCAGCAATTAAATTtgagccgcagcaacagcaacgccaAGCGGATGATCATTATTACGAACAGGATTGGCCTTTGTACCAGGAACAGGAAGAGGATCAGGTGCAAGACCAGATGCAGCAAatggagcaggagcagctggTGGAGCCGCAGGCCAGCTATGCAGCGGTTAGCGCTGTGTCCGTACCAACAGCCACGCGCGGACGCATTAGCCGCCTCAAGCCCAAAGAAGAGAGCACGCAGTACATTGTGATTGCCGAGAAGCAGCCAACTGACGATTTGCGCCAGTACATGGATTGCGaggagctgccgctgcagccgcCGCTCACTGGCAGCACGTCAATCGAGGCAGCGCATTCGACACAGTGCCCAGACGGCCCAGTCGCCGATGGGGCAGAGACGCTACGCTTCCCGGTGCTGGACGAGAGCAAGCCCTTTGTGTGCCAGCAGTGTGGACTCGCATTTGCGCGCGAAAAAGCGCTCGTCTCGCATATCAAGAATCATCGCGTGGACTCGCCCTTCGAATGCAATCAGTGTCAGGAGATGTTCTGGGATAATTACAGCTTGCAGGAACATCAGAAGACACATCAGTTCGAGGAGAGCAACTCGGAATATGATCCGGCTTCGGCAGGCGAAGATAGCGCCAGCGAATCGGATCCGGAACAGCTTTACGGTGACTTCTACTGCAGCGAGTGTGGCATTTCCTTTCACAGGCAGGACCTGCTGCGTCGTCATGCCAAGCAACAGCACAAGCTGACACCAGACATGGAGGGCGGCGacggcggtggcggtggcggcggcggaggtgacggcgacggcgacggcggcgatGCTGATGCCGAAAATGCCAAAGAGGCCGCGCACTGTTGTCACACATGCGGCAAATCGTTTCCCAGCGCACTGGAGCTGCTCGCCCATGCCGAGGTCCATGCACGATTCCCGCCATTCAAATGCGTCCTGTGCGGTGTTAGCTTTTACGAGGAGCAGGCTATCAAGCGGCATTTGCACACGCGCCATCCGCACGAGCTGAAGCCTAACTCGTGCGTGCTGTGCGGCAAAGAGTGTCGCGATCGCAAGGCACTAATCAAGCACGCCTGGGATCACTCGCGCGAGAAGTGCCACTCGTGCTCCAAGTGCGGCAAGAACTTTCACAACAAGGCGCGCCTGAAGCGACACATGGCCTCGCATCGCGACAAGTCGGTGGTTTGCGAGGTGTGCCACGAGGAGTTCCCCGATGGACGCACGCTCTCCAATCATCGGCATTCACATAGCACCACATCGCCGGGCAAGCTGTTTCCCTGCCACGAGTGCGGCAAGACCTTTGGCTCGCGCAGCTCACAGCAAATACATGTCCGCATCCACACTGGCGAACGGCCATATGGCTGTCGCTACTGCTGGAAGGCGTTTGCCGATGGCGGTACGCTGCGCAAGCACGAGCGTATTCACACGGGCGAAAAGCCCTATGCCTGTTCCGTGTGTCCGCGTGCCTTCAACCAGCGCGTTGTGCTGCGCGAGCACATACGCTCCCATCACTCGGGTCTGGATGCGGTACGTGGCACCTATCATTGCACCGTCTGCTCGGCCGATTTGTCCTCATCCAATGAGCTTATACAGCATCTCATCCAGCACAGTGACACGAACACCGCCAAACAGCGACAGCCAATTacTGGTCCGCGCAAGTATAAGCGACGCAGGAAACTGCAGCCACACGAGATTGCCCACATGCGTGCGGGGAACAAGGATGGCGAGGAGTATGTCAGCGATATGGAACTATGTGACTTTGATGTTGAGAACGTGGATGATCTCCTGGAAAAGACAGAGCCATTGCCAACTAAAAAGGAGAAGCGCAAGCGAGCAGCTGCAAATCAAGCTAAACCCGTGACAAATGGCGCCGCACACAATAGTTCCAGTTCTGCCAAATCCGCCAATAGCAGCTCCGAACGTCTGTGGGATGAGAAATTCCTGCCGGCAAATAGCAATGGCAATGTTGGCAGCGCAGATGATGCCTACAAAAGCTTCTTTCAAATTGATTCGCTGGTGGTGGTAAACGATACCACTCTGCCGCCTATAAGCTCATCCAGCAGCATACCAAGCGCCTCCAAGTCGCGACGCGGCGGCAAGCAGCCACCGACGCAAACCCAGGCCGAAAGCAGTGACAAGTCAGGAGGTGGAGCGGGACCAAAAGcatcagcaacaacgacaataacaacagcagcggctgGTGAGGAGTCTGGCAAATCCAGCGTCGCcaacagtcgcagcagcagaaagaaGTCTAGCAAGGCGGCCAAGAATACAggcacagcagctgccacatcAAGCAGTTCACGTCCCCGCATGATACACACAGAAAAGGCACGAGTGCCGCCAGAGAATGCCAGCAAAAAGTCGCGTGGTCGCAGCTACATAACGCGCACCAGTACCAGCGAGAGCAGCCAGCTGGGCCTGGTCAAGTCGAGCGGCGTGGCCAGTTCGCGGATTGTCGATGACTACGAAATTATATCACCTGCCACACAGCCGCCAAATCAGATCAGCTCCAGTCCGCTGCACATcaagcaggagcaggagcaccaacagcagcgcGTCCAGCTCATGTACGATGACACCCATTTGCTGATCCATGCGGCCATGTTGCGCGAGAAGCCCTACGATAAGTTCAATCCGAGCATTGTCAATGATCTGGAGGAGATATTACGCAGTCCGCTCAAGCATGATCGGAATGCGCGCCTGCGTTTCACTAGCGAATCGTCGACAACGCCACAGTTTCTGCCCGAGGAGGAGCAGAACCTCATTAAAATTGAGCCCACGTCTCCGGATCTGCGCGAAATGGTGGAGAGCCAGCAACGTGTAACTGCCACAGGAcacacagccacgcccacatcatcatcatcatcctcatcGGCGGCGCGCACATCGCGCCATCTGCGACAGATCACTGCCAACTCGGCCACCCGCTCGGCAGCCAAGAGACACATGGACAAAAGCTCATCCGAATTCAGCGCCAAGAAATCGACAACATCCTCGCCCGTTGCAGTCAATAAGCCAGCCGGCAACTCGTACCTCAGCTATGGCGTGGACTCGTACAATGTGAATGTGGTGGCCAGTGCCAACTCATCGGATGTCAGTTCCGGTTTCTTTTCCATCTCCGAGGTGGTATCCGCTGCACATGCCGCCGATGCAGCCGCCAAGGCGGCAGCGGCCAGCAAAACGGAGCGTCGGACGCGCTGCTTTGAGTGTGAAATGTGCTCCTCCATATTTCCGGATCGCGCCCAGCTGCTGGAgcacatgcatatacacatcTGA
Protein Sequence: MNNQDYGGIQWIQQHASAVDSETDMLENGAADSEVTAAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANEAGGGTVLITDSGTVAYAESFDDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNNSSQELLDMEQDEYTALRPYPCDFCSRRFRKKGSLNTHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADEAAAIKFEPQQQQRQADDHYYEQDWPLYQEQEEDQVQDQMQQMEQEQLVEPQASYAAVSAVSVPTATRGRISRLKPKEESTQYIVIAEKQPTDDLRQYMDCEELPLQPPLTGSTSIEAAHSTQCPDGPVADGAETLRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNYSLQEHQKTHQFEESNSEYDPASAGEDSASESDPEQLYGDFYCSECGISFHRQDLLRRHAKQQHKLTPDMEGGDGGGGGGGGGDGDGDGGDADAENAKEAAHCCHTCGKSFPSALELLAHAEVHARFPPFKCVLCGVSFYEEQAIKRHLHTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAVRGTYHCTVCSADLSSSNELIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAGNKDGEEYVSDMELCDFDVENVDDLLEKTEPLPTKKEKRKRAAANQAKPVTNGAAHNSSSSAKSANSSSERLWDEKFLPANSNGNVGSADDAYKSFFQIDSLVVVNDTTLPPISSSSSIPSASKSRRGGKQPPTQTQAESSDKSGGGAGPKASATTTITTAAAGEESGKSSVANSRSSRKKSSKAAKNTGTAAATSSSSRPRMIHTEKARVPPENASKKSRGRSYITRTSTSESSQLGLVKSSGVASSRIVDDYEIISPATQPPNQISSSPLHIKQEQEHQQQRVQLMYDDTHLLIHAAMLREKPYDKFNPSIVNDLEEILRSPLKHDRNARLRFTSESSTTPQFLPEEEQNLIKIEPTSPDLREMVESQQRVTATGHTATPTSSSSSSSAARTSRHLRQITANSATRSAAKRHMDKSSSEFSAKKSTTSSPVAVNKPAGNSYLSYGVDSYNVNVVASANSSDVSSGFFSISEVVSAAHAADAAAKAAAASKTERRTRCFECEMCSSIFPDRAQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00582391;
90% Identity: iTF_00563313;
80% Identity: -