Dbir015554.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila birchii
Gene Symbol
KEAP1
Assembly
GCA_008042755.1
Location
VNKA01003715.1:244485-248346[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.7e-32 5.7e-30 103.8 0.1 4 109 83 186 80 187 0.96

Sequence Information

Coding Sequence
ATGCAAACCCAAATGCAGACACAAATGCAGTATGAGAATCATATCTCATCTCCATCCTATCAAATGAATAGTCGCCTCCAAGAAGAGGCTGAGATGAACAACCATGCTGAAAGTTGTTCCACCTCGTCGTCGTTCGGGCGGTGCGGGTCGACGCACTCGCAGATTGATGACCACGATGCCACGGACGACGACATGACCTTCTGCATGTCCAACTACGCCAAGGAGGCCTTGAAGATGATGTTCATGATGCGGTCCCACGGCATGCTCACGGACGTGGTGCTCGAGGTGAAGAAGGAGCTCTTTCCCGCCCACAAGGTTGTGCTGTCCGCAGCGTCGCCTTATTTCAAGGCCATGTTCACGGGCGGACTCAAGGAATCGGAGATGTCGCGCGTCCAGCTGCAGGGGGTCTGTCCCACGGCCATGTCGCGCATCCTGTACTTCATGTACACCGGCCAGATCCGTGTGACTGAGGTGACGGTGTGCCAGCTCCTGCCGGCTGCCACCATGTTCCAAGTGCCAAACGTAATCGACGCCTGCTGTGCCTTCCTCGAGCGTCAGTTAGATCCCACAAATGCCATTGGCATTGCCAACTTTGCCGAGCAGCACGGCTGTGTGGATCTACAGAAGAAGGCGAATGTGTTTATCGAACGAAACTTTACACAGGTGTGCCAAGAAGAGGAGTTTTTCCAGCTAACGGCCTATCAGTTGATAGCCCTCATCCGTCGGGATGAGTTGAATGTGCAGGAGGAGCGAGAGGTCTACAATGCAGTGCTCAAGTGGGTCAAATACGACGAGGACAATCGCCACTGCAAGATGGAGCACATTCTGGGCGCTGTGCGCTGTCAGTTCTTAACGCCCAACTTCCTCAAGGAACAGATGAAAAACTGCGACGTTCTGCGCAAGGTTCCCGCCTGCCGCGAGTATTTGGCCAAAATCTTCAAGGACTTGACGCTACACAAGTGTCCGGGTGTTAAGGAACGGACACCCAACACCACTCGCATGATCTTCGTGGCGGGCGGCTTCTTCCGCCACTCGCTGGACATACTGGAAGCCTACAATGTGGACGACAAAACGTGGACAACGCTACCAAATCTACGCATTCCCAGATCCGGCTTGGGTGCCGCTTTCCTCAAGGGCAAGTTCTATGCGGTCGGCGGACGAAATAACAACATTGGCTCCTCCTACGACTCGGATTGGGTGGATCGTTATAGTGCCGTCAGCGAGACGTGGCGTCCCTGCGCACCCATGTCCGTGCCCCGACATCGCGTAGGCGTTGCGGTCATGGACGAGCTCATGTACGCCGTGGGTGGATCCGCGGGCATGGAGTACCACAACACCGTGGAATTCTATGATCCCGACATGGATCGCTGGACACTGGTGCAGCCGATGCATTCCAAACGCTTGGGCGTTGGTGTGGTGGTGGTCAACCGCCTGCTCTATGCCATTGGCGGCTTCGATGGGAACGATCGTTTGGGCAGCGTGGAGTGCTACCATCCGGAGAACAATGAGTGGAGTTTCCTGCCACCGCTCCAAACCGGTCGCAGTGGAGCAGGCGTGGCTGCAATTAACCAGTACATCTACGTGGTCGGCGGCTTCGATGGCACCCGACAGCTGGCCACAGTTGAGCGCTACGATACGGAGAACGAGACCTGGGATATGGTTGCGCCCATTCAGATCGCCCGTAGTGCCCTGTCGCTGACACCGCTGGACGGCAAGCTGTACGCCATAGGTGGATTCGATGGCAACAATTTCCTGTCCATCGTGGAGGTGTACGATCCGCGGACAAACACGTGGGTTAAGGGCACGCCATTGAAGTCGGGACGTTCCGGTCATGCCTCAGCGGTTATCTATCAGCCTGCGTGTGCCACCACATTTATGGACTACGAGGAGAGCGAGGACACGACGCGAGGGGATGGAAGCCATGAGGACGAAAGGTTCAGGGACTCGTCGTCACAGGATCCGAGCAGTAGTCGGAGTCCACACTCATACTCTGCGCCCAACATGCAGTTCCATACGTCGTTCGGCATGAAAGGCTGCAACAACTGCGATTCCGAGGTAGATGTAAAGCAAGAAGTCACGGCAGACACGCGGAACTTTCAAATTCCTGCCATTAAAAATGAAGAGCTGAGCAATCCCCTGTGTCCCTGGTCCAGAATGCAGAAGAAATTGCGATGGTCATGCACCGAAAGCGAAAACATCCAATCAACAGATTTAACACACAAATTCGATAAAGCGCGGAAAAAGTGCATACTAAGCACAGCGGCGAAAGTGATACATAACCACATCGAAGGCCGCCTGCGGAAACTGGCGGCCACATGA
Protein Sequence
MQTQMQTQMQYENHISSPSYQMNSRLQEEAEMNNHAESCSTSSSFGRCGSTHSQIDDHDATDDDMTFCMSNYAKEALKMMFMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIANFAEQHGCVDLQKKANVFIERNFTQVCQEEEFFQLTAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCPGVKERTPNTTRMIFVAGGFFRHSLDILEAYNVDDKTWTTLPNLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVSETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEFYDPDMDRWTLVQPMHSKRLGVGVVVVNRLLYAIGGFDGNDRLGSVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENETWDMVAPIQIARSALSLTPLDGKLYAIGGFDGNNFLSIVEVYDPRTNTWVKGTPLKSGRSGHASAVIYQPACATTFMDYEESEDTTRGDGSHEDERFRDSSSQDPSSSRSPHSYSAPNMQFHTSFGMKGCNNCDSEVDVKQEVTADTRNFQIPAIKNEELSNPLCPWSRMQKKLRWSCTESENIQSTDLTHKFDKARKKCILSTAAKVIHNHIEGRLRKLAAT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00533154; iTF_00593894; iTF_00492295; iTF_00612873; iTF_00525937; iTF_00485204; iTF_00489432; iTF_00490140; iTF_00527420; iTF_00613568; iTF_00580038; iTF_00566151; iTF_00477392; iTF_00488080; iTF_00539025; iTF_00481599; iTF_00546026; iTF_00504051; iTF_00614965; iTF_00609228; iTF_00483043; iTF_00594608; iTF_00617710; iTF_00491571; iTF_00571957; iTF_00524473; iTF_00590298; iTF_00480230; iTF_00531718; iTF_00606382; iTF_00478075; iTF_00541134; iTF_00561822; iTF_00562531; iTF_00472420; iTF_00556588; iTF_00608505; iTF_00557978; iTF_00604906; iTF_00605633; iTF_00515652; iTF_00550308; iTF_00588260; iTF_00615625; iTF_00578603; iTF_00591755; iTF_00494446; iTF_00486677; iTF_00475990; iTF_00529622; iTF_00505463; iTF_00602715; iTF_00581597; iTF_00565438; iTF_00536831; iTF_00548127; iTF_00602655; iTF_00512064; iTF_00507720; iTF_00504748; iTF_00607871; iTF_00603403; iTF_00563971; iTF_00601115; iTF_00514950; iTF_00474557; iTF_00487358; iTF_00508396; iTF_00563236; iTF_00531014; iTF_00616966; iTF_00473127; iTF_00573384; iTF_00588907; iTF_00554445; iTF_00598221; iTF_00585263; iTF_00493715; iTF_00526643; iTF_00532438; iTF_00509879; iTF_00572663; iTF_00490841; iTF_00502587; iTF_00547420; iTF_00506175; iTF_00546719; iTF_01326477; iTF_01321992; iTF_01322716; iTF_01324190; iTF_00530328; iTF_00541823; iTF_00561101; iTF_00567599; iTF_01319825; iTF_00336817; iTF_00335969; iTF_00338410; iTF_00339227; iTF_00891955; iTF_00891045; iTF_00890193; iTF_00589604; iTF_00509162; iTF_00614250; iTF_00520694; iTF_00595306; iTF_00337599; iTF_00919124; iTF_00480920; iTF_00536103; iTF_00517770; iTF_00473840; iTF_00484498; iTF_00580797; iTF_00471678; iTF_00574878; iTF_00592448; iTF_00539716; iTF_00619205; iTF_00596716;
90% Identity
iTF_00533154;
80% Identity
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