Dbir017904.1
Basic Information
- Insect
- Drosophila birchii
- Gene Symbol
- Mbd2_1
- Assembly
- GCA_008042755.1
- Location
- VNKA01003713.1:416158-417792[-]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 7.1e-21 2.7e-17 62.2 0.0 1 54 8 81 8 91 0.95 2 2 2.1e-06 0.0079 15.9 0.0 27 76 145 205 126 206 0.90
Sequence Information
- Coding Sequence
- ATGCAGAACCCGAGCGTCACAATTGAGCGCAAACGCGTCGACTGCAGTGCCCTGCCGAAAGGATGGCAGCGCGAGGAGGTCCGCAAGTCTGGGAGCAGCTCCAATAGCAACGCCAGcgccaccaacaccaccaccgccagcaacaacaacaacaacaacaacaataacaaggtGGATGTTTTCTACTACAGTCCCACAGGAAAACGGGTCGAGAGCAAGCCGCAGTTGGCGCGGCAATTGGGCGGCGACGGTGGCCACGGATCGGCGGCCAACGCCCTCAAGCGCAAATTGGCCCGCTCGCAGCTGGGCAGCCAGGCCAGTGCAGGATCTGGCTCGGGATCAGCTCCAATttcagcggcggcggcagcaggagttgcctcctcctcctcgcccaCGGCAGGCAGccgccagcaacagcagattGAACTCAGCCGGGCCCTGCGCACAGATGTCTCCCTGGTGCCACCCATTCGACAGACTGCCTCGATCTTCAAGCAACCGGTTACGGCGATTCGAAACCACACCGAGGATCCCGGTAAGGTGAAGCCCGATGCCAAGCATGGCACCCAGGAGAAGCCCAAACAGTTGTTCTGGGAGAAACGACTGGAGCGACTGCGCGCCTGCCACGACAATGGCGAGGAGCTCGACGACATCTCACTGCCCAAAACCATACGCACCGTTGGCCCCAATGTCAACGAACAGACCGTCCTCCAATCGGTGGCTACCGCTCTGCACATGCTCAATGCCGGCGTACACGGCCAGAGTTCGACAAAGGCTGACTTGACCAAGAATGCGATGGCATTCATGAATCCCGAACAGCCGCTCATGCATGCGGTGATCATCTCCGAGGACGACATTCGGAAGCAGGAAGATCGCGTCGGCGTGGCGCGGCGAAAGCTGCAGGATGCACTCAAGACATGA
- Protein Sequence
- MQNPSVTIERKRVDCSALPKGWQREEVRKSGSSSNSNASATNTTTASNNNNNNNNNKVDVFYYSPTGKRVESKPQLARQLGGDGGHGSAANALKRKLARSQLGSQASAGSGSGSAPISAAAAAGVASSSSPTAGSRQQQQIELSRALRTDVSLVPPIRQTASIFKQPVTAIRNHTEDPGKVKPDAKHGTQEKPKQLFWEKRLERLRACHDNGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -