Dbif011732.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila bifasciata
Gene Symbol
croc
Assembly
GCA_009664405.1
Location
CM019043.1:47417903-47419540[+]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 9.2e-43 1e-39 134.2 0.1 2 87 71 155 70 156 0.97

Sequence Information

Coding Sequence
ATGCATACTCTATTCAGTGATCAGAATTCCTTTAGCCGCCACTATGCCGCCCAGACAGCCGCCGGCTATAGCTCCGCGTCTGCGGTGGCAGCGGCCAGCAGCGCCtcagcggcagcagccgccCACTATGCCTACGATCAGTACTCCCGCTATCCGTACTCGGCCAGTGCCTACGGCCTGGGTGCACCGCATCAGAACAAGGAGATCGTGAAGCCGCCCTACTCCTATATCGCGCTCATCGCGATGGCCATCCAGAATGCGTCGGACAAGAAGGTGACGCTGAATGGCATCTATCAGTACATTATGGAGCGGTTCCCCTACTACCGGGACAACAAGCAGGGCTGGCAGAACTCCATCAGGCACAATCTCAGCCTCAACGAGTGCTTCGTGAAGGTGGCCCGCGATGACAAGAAGCCCGGCAAGGGCTCCTACTGGACCCTGGATCCGGACTCCTACAACATGTTCGACAATGGCTCCTTTctgcgacggcggcggcgctTTAAGAAGAAGGACGTGATGCGCGAGAAGGAGGAGGCCATTAAGCGGCAGGCGATGATGAACGAAAAGCTGGCCGAGATGAAGCCCCTCAAGCTGATGACCAATGGCATTCTGGAGGCCAAGCATATGGCCGCCCATGCCGCGCACTTCAAGAAGGAGCCGCTCATGGATCTGGGCTGCCTCAGCGGCAAGGATGTCACCCATGCGGCCATGCTCAACTCCTGCCACGACAGCCTCGCCCAGATGAACCATCTGGCGGGCGGTGTGGAGCATGCCGGCTTCACGGTGGACTCCCTGATGAATGTCTACAATCCGCGCATACATCACAGCGCCTATCCGTATCACTTGAACGACGACAATCTGGCGTCGGTGGCCAGCAGTCAGATGCATCATGTGCATCATGCGGCCGCCGCTCATCACGTTCAGCAGCTGCGGCATGTGGGTCATGTGTCGCATCCGCTTACGCCTGgcggtgggggtggtggtgcagCAGGCGGCGGCGCACACAACAGCGGTGGCATTCAATCCTCCTCGGGACATTCGCCCACTACGATCTCAACGCCTCATGGACCGGCGCATGGTGGTTGGTATACGCCGGAGACGCCACCCTCAGAGCCCATACCCAATGGCGGTGGACAGCAGGGCACGCCCACACATACCGGccacaacaataacagcaacaacaatcccAGCAatcccaacagcaacaacaacaacaacaactcgagtgtgcacaacaacaaccacagtcacagtcacagccatagtcacgggcacgggcacagtcacagtcacaacggaggcggcggcggcggcgcctCCTCTGTGCTAACAGCCAGTCCAAGCTCCGCTTTGGGTTTCCGCGACATGATCTTCGAGCAGAATCAATCCTGCCAACTGGACACTGGCAGTCCCACCGGCAGCCTGCAGTCGGCCAGTCCCCCCGCATCCGCGAGTGTGGCAGCAGCCtcggcagcagccgccgcggCGGTGATCAGCagccaccatcatcatcatcatcatcacgcGTTGAGCGGGAATCTGGGGCAGCTGGGCCAGCTGGGGCAGCTAAGCAACCTGAGTCACTATCGCCCCCACATGGGGCACTATCAGGAGTATGGCATCAAGTATGGTGTCTAA
Protein Sequence
MHTLFSDQNSFSRHYAAQTAAGYSSASAVAAASSASAAAAAHYAYDQYSRYPYSASAYGLGAPHQNKEIVKPPYSYIALIAMAIQNASDKKVTLNGIYQYIMERFPYYRDNKQGWQNSIRHNLSLNECFVKVARDDKKPGKGSYWTLDPDSYNMFDNGSFLRRRRRFKKKDVMREKEEAIKRQAMMNEKLAEMKPLKLMTNGILEAKHMAAHAAHFKKEPLMDLGCLSGKDVTHAAMLNSCHDSLAQMNHLAGGVEHAGFTVDSLMNVYNPRIHHSAYPYHLNDDNLASVASSQMHHVHHAAAAHHVQQLRHVGHVSHPLTPGGGGGGAAGGGAHNSGGIQSSSGHSPTTISTPHGPAHGGWYTPETPPSEPIPNGGGQQGTPTHTGHNNNSNNNPSNPNSNNNNNNSSVHNNNHSHSHSHSHGHGHSHSHNGGGGGGASSVLTASPSSALGFRDMIFEQNQSCQLDTGSPTGSLQSASPPASASVAAASAAAAAAVISSHHHHHHHHALSGNLGQLGQLGQLSNLSHYRPHMGHYQEYGIKYGV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00542241; iTF_00565889; iTF_00576865; iTF_00616705; iTF_01319553; iTF_01320993; iTF_01558081; iTF_01551522; iTF_01550793; iTF_01556630; iTF_01550079; iTF_00510338; iTF_00597954; iTF_01549378; iTF_00506659; iTF_00514691; iTF_00522755; iTF_00554883; iTF_00603885; iTF_00585763; iTF_00501604; iTF_00552836; iTF_00582761; iTF_00516794; iTF_00513980; iTF_00518244; iTF_00530756; iTF_00523493; iTF_00527109; iTF_00562981; iTF_00568773; iTF_00470665; iTF_00590053; iTF_00482786; iTF_00479976; iTF_00606121; iTF_00608982; iTF_00918853; iTF_00515398; iTF_00541574; iTF_00560841; iTF_00567338; iTF_00495661; iTF_00547161; iTF_00564454; iTF_01555238; iTF_00504487; iTF_00592193; iTF_00539461; iTF_00596456; iTF_00494187; iTF_00618955; iTF_00591503; iTF_00505204; iTF_00529367; iTF_00607614; iTF_00595047; iTF_00595751; iTF_00916999; iTF_01553767; iTF_00359272; iTF_00474312; iTF_00508904; iTF_00613991; iTF_00520433; iTF_00584232; iTF_00805768; iTF_00557705; iTF_00589353; iTF_00901289; iTF_01323913; iTF_00475018; iTF_00517514; iTF_00526378; iTF_00802634; iTF_00803402; iTF_00500107; iTF_00511075; iTF_00527846; iTF_00560040; iTF_00597160; iTF_00496394; iTF_01322443; iTF_00482031; iTF_00521968; iTF_00609680; iTF_00606868; iTF_00543543; iTF_00573847; iTF_00619641; iTF_00558459; iTF_00548605; iTF_00494910; iTF_00521150; iTF_00524926; iTF_00497184; iTF_00594347; iTF_00613313; iTF_00488518; iTF_00612616; iTF_00484940; iTF_00491315; iTF_00492025; iTF_00489179; iTF_00489884; iTF_00477821; iTF_00540893; iTF_00336524; iTF_00480684; iTF_00473585; iTF_00471411; iTF_00513260; iTF_00552108; iTF_00535113; iTF_00498670; iTF_00831948; iTF_01327692; iTF_00545773; iTF_00503798; iTF_00614713; iTF_00561549; iTF_01323181; iTF_01552973; iTF_00518958; iTF_00534383; iTF_00544271; iTF_00610447; iTF_01320271; iTF_01558831; iTF_00538032; iTF_00575376; iTF_00603152; iTF_00917872; iTF_00338129; iTF_00335667; iTF_00338943; iTF_00535857; iTF_00563697; iTF_00602385; iTF_00486374; iTF_00604639; iTF_01548657; iTF_00574610; iTF_01326194; iTF_00919667; iTF_00554196; iTF_00478517; iTF_00553557; iTF_00472164; iTF_00581333; iTF_00583477; iTF_00608241; iTF_00593653; iTF_00532911; iTF_00617437; iTF_01555925; iTF_00528598; iTF_00530070; iTF_01326966; iTF_00490583; iTF_00505911; iTF_00536567; iTF_00578327; iTF_00570199; iTF_00576146; iTF_00599383; iTF_00618167; iTF_00507416; iTF_00557016; iTF_00570936; iTF_00600856; iTF_01325464; iTF_01554488; iTF_00484249; iTF_00547865; iTF_00804986; iTF_01355930; iTF_00508123; iTF_00588667; iTF_01570043; iTF_00477148; iTF_00475745; iTF_00481354; iTF_00579789; iTF_00550062; iTF_00615388; iTF_00531487; iTF_00492764; iTF_00537308; iTF_00555644; iTF_00500841; iTF_00577580; iTF_00590770; iTF_00600114; iTF_00483486; iTF_00571708; iTF_00580508; iTF_00485661; iTF_00499389; iTF_00525693; iTF_00566589; iTF_00592893; iTF_00804189; iTF_00914301; iTF_00915133; iTF_00524222; iTF_00565182; iTF_00569502; iTF_00511807; iTF_00562271; iTF_00605375; iTF_00611199; iTF_00916031; iTF_01324703; iTF_00487808; iTF_00538765; iTF_00497952; iTF_00616000; iTF_00598682;
90% Identity
iTF_00514691;
80% Identity
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