Dbak026451.1
Basic Information
- Insect
- Drosophila bakoue
- Gene Symbol
- bs
- Assembly
- GCA_008044335.1
- Location
- VNJL01010651.1:514236-519513[-]
Transcription Factor Domain
- TF Family
- SRF
- Domain
- SRF domain
- PFAM
- PF00319
- TF Group
- Helix-turn-helix
- Description
- Serum response factor (SRF) is a ubiquitous nuclear protein important for cell proliferation and differentiation. SRF function is essential for transcriptional regulation of numerous growth-factor-inducible genes, such as c-fos oncogene and muscle-specific actin genes. A core domain of around 90 amino acids is sufficient for the activities of DNA-binding, dimerisation and interaction with accessory factors. Within the core is a DNA-binding region, designated the MADS box [2], that is highly similar to many eukaryotic regulatory proteins: among these are MCM1, the regulator of cell type-specific genes in fission yeast; DSRF, a Drosophila trachea development factor; the MEF2 family of myocyte-specific enhancer factors; and the Agamous and Deficiens families of plant homeotic proteins. In SRF, the MADS box has been shown to be involved in DNA-binding and dimerisation [1]. Proteins belonging to the MADS family function as dimers, the primary DNA-binding element of which is an anti-parallel coiled coil of two amphipathic α-helices, one from each subunit. The DNA wraps around the coiled coil allowing the basic N-termini of the helices to fit into the DNA major groove. The chain extending from the helix N-termini reaches over the DNA backbone and penetrates into the minor groove. A 4-stranded, anti-parallel β-sheet packs against the coiled-coil face opposite the DNA and is the central element of the dimerisation interface. The MADS-box domain is commonly found associated with K-box region see (IPR002487).
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 8.2e-25 1.1e-20 73.3 0.1 1 48 191 238 191 238 0.98
Sequence Information
- Coding Sequence
- ATGGATCCGACGCGGGGCGACTCGCGCTACAACCTGAACTACTCGATGAGTAGTATCGGGCTGAGCCTCTCCGATCCCTCGGACATGTACGGCAACCCGGCTGTGGCCGCCCTGGGCGCCCGCCCGCCCTCCGGCGGCCTCCTCCAGAGCATGGGCGGCggcgcaggcggcggcggcggtgtgcCGTCCATGCAGCGGCCAAATCCCGCCACCGGAGCCACAGCAGCCCAGTGCCAGACCCTACACAGCCCCCAGCACGCCtcccaacaacagcagcagcagcagcagcagcaacagcagcagcaacaacagcagcagcagcaacaccagcagcagcagcagcagcaacaacagcagcagcaacatcgcgGCCTGAAGCGTTCGGGAAGCGACTGCTACGAGGATCACCATCGATCCGCCGGCGGACTGACGCTCCAGGGACTCGACAGCGTGGCCAGCAGCGCCGGCGGCGTCGAGGACAACGTGGATGGCTACAACCCGCTGCCCAACAAGAAGTCACCGCCCGCCAACGGCAAGAAGACAAAGGGACGtgtcaaaatcaaaatggaaTACATCGACAACAAGCTGCGTCGCTACACGACCTTCTCCAAGCGCAAGACGGGCATCATGAAGAAGGCCTACGAGCTGTCCACGCTGACCGGAACGCAAgtgatgctgctggtggccaGTGAGACGGGCCACGTGTACACATTTGCCACGCGCAAGCTGCAGCCGATGATCACCTCGGAGGCGGGCAAACAGCTCATCCAGACCTGCCTTAACTCGCCGGATCCGCCCAGCGTCGGTGGCGGCGACCAACGGATGTCGGCCACCGGCTTCGAGGAGACGGAGCTCAGCTACAACATCGCCGACGAGGACTCCAAAGTAAGACAATTGATTTACGGTCACCATGGGCACGCTCATCTGGCGCACCCGCCGGCGCCGCCCTCGCACTACAGCCTCGAGCAGAGTCTGATGCAGTCCGGCTACAGTGGCGGCCAGGCGTCGCCCCTGTCCCACGCCCAGGCCTACGGCGGACATGCGCACCATGCGCATGTGCCGCACGTGCCGCCGCCGCATTCGACGCACTCGCACATGTCGCACACGCATGCGCAGCGCTAG
- Protein Sequence
- MDPTRGDSRYNLNYSMSSIGLSLSDPSDMYGNPAVAALGARPPSGGLLQSMGGGAGGGGGVPSMQRPNPATGATAAQCQTLHSPQHASQQQQQQQQQQQQQQQQQQQQHQQQQQQQQQQQQHRGLKRSGSDCYEDHHRSAGGLTLQGLDSVASSAGGVEDNVDGYNPLPNKKSPPANGKKTKGRVKIKMEYIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVMLLVASETGHVYTFATRKLQPMITSEAGKQLIQTCLNSPDPPSVGGGDQRMSATGFEETELSYNIADEDSKVRQLIYGHHGHAHLAHPPAPPSHYSLEQSLMQSGYSGGQASPLSHAQAYGGHAHHAHVPHVPPPHSTHSHMSHTHAQR
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00483648;
- 90% Identity
- iTF_00612770; iTF_00533061; iTF_00571855; iTF_00525840; iTF_00561715; iTF_00489334; iTF_00593794; iTF_00477976; iTF_00482937; iTF_00480122; iTF_00606264;
- 80% Identity
- -