Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.31 3.7e+02 1.6 0.7 6 66 13 22 5 27 0.63

2 3 3.4 4e+03 -1.7 1.5 7 15 164 172 158 185 0.64

3 3 2.3e-12 2.7e-09 37.3 14.9 5 70 196 260 192 260 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.31	3.7e+02	1.6	0.7	6	66	13	22	5	27	0.63
2	3	3.4	4e+03	-1.7	1.5	7	15	164	172	158	185	0.64
3	3	2.3e-12	2.7e-09	37.3	14.9	5	70	196	260	192	260	0.91

Coding Sequence: ATGTCCATGGCTTCACCTCACAAAGATGTGGAGTACATGCGCTGCATGCATTGCCAGAAAGTGATCCGTATCTCCCGCTGCGATACCAGCGGCCTGGTGCGCCACGTCGAGTTGGATCACCCGAGTAAGTGCACGGTGCCCAGCAAGAAGTGCAAGGAGCCGCCATCGTCGGTCACGTCCCAGATGTCCGAGAAGACGGAGCAGTCCTGCGAGAAGGACAAGAAGTCTCCCATGCCAGCCTCATCCGAGATCTCCGATAAGACAGATCAATcCAGCGAGAAGATCAAGAGAATGCACATGCTGGCCGCGCAGCACGGGATCAGCGAGGAACGCCTCTCGGAGATAAGCAGAAAGACGGGTCTCTCTCAGGCCCAGATGGCCGATAAGGCGGAGGCGTATATGGCCAAGAAATTTGGTAAATCGCACAGCGAAGCCTCTAGTGGTGGCGAAAAGAATGAACCACCGACCGCTCCACCCCCCAAGAAAGATATCTGCCCGCCCTGTGCTTGTCGCTCTGAAAAGGAGCAGGCACATCGACGGCAGTGCTACAGGGTCTCCATCAGGCGCTGGATTCCAGCGGAGGGCTGCATTTTCTGTCCTTGCTGTGGCTGCAGTCGCCGCCCGCTGATCAAGGCCGCCTCGGAGATCATGACCTCCGGCTGCTGCGCCACCTGGGTTGTAATCTGTTGGCCCCTGTGCCTCCTGCCCTGCCTGCTCTCCTCGGATAACCGGGAGTATCTGTACTGCTCCAATTGTCACGTCTTTCTGGGCATCTATGAGCGGGAGAAACGCTGCGTGAGGCCCAGCCGGGAGTTTGTGTCCTGTTGCAACTCGGCCACGCCCCCGCCAACGGCGAGGTAA
Protein Sequence: MSMASPHKDVEYMRCMHCQKVIRISRCDTSGLVRHVELDHPSKCTVPSKKCKEPPSSVTSQMSEKTEQSCEKDKKSPMPASSEISDKTDQSSEKIKRMHMLAAQHGISEERLSEISRKTGLSQAQMADKAEAYMAKKFGKSHSEASSGGEKNEPPTAPPPKKDICPPCACRSEKEQAHRRQCYRVSIRRWIPAEGCIFCPCCGCSRRPLIKAASEIMTSGCCATWVVICWPLCLLPCLLSSDNREYLYCSNCHVFLGIYEREKRCVRPSREFVSCCNSATPPPTAR

Sequence clustering based on sequence similarity using MMseqs2