Basic Information

Gene Symbol
-
Assembly
GCA_008121215.1
Location
CM017796.1:8469878-8471758[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.00021 0.014 15.6 3.4 1 23 181 204 181 204 0.96
2 9 0.0012 0.081 13.2 0.8 1 23 229 252 229 252 0.98
3 9 0.017 1.2 9.5 0.0 1 23 267 290 267 290 0.97
4 9 6.9e-05 0.0047 17.1 3.5 3 23 295 315 294 315 0.97
5 9 0.012 0.84 10.0 4.4 3 23 323 345 322 345 0.92
6 9 1e-06 6.9e-05 22.8 2.1 1 23 351 373 351 373 0.98
7 9 6.5e-06 0.00044 20.3 0.9 3 23 381 401 379 401 0.98
8 9 0.00026 0.018 15.3 2.8 1 23 407 429 407 429 0.95
9 9 0.00012 0.0083 16.3 0.0 1 23 435 457 435 457 0.98

Sequence Information

Coding Sequence
ATGCTGAAGTGCCTCAAAGCGGACACCTACGCCGGCATGGCCAATGCCAAGTGCGGCGAAATCTATTTCCAGAGCCTGGACAGTTTTCGCATCGATTGTGCCTTTTGTGAAATGAAGAGCTTTGTGTTTAATGACTTTCTGCTGCACGTCCAGAACATCCACTTCGAGAACGGCCTGCTCAAGACAGAGCTCAAGGAGGAGAAAGAACTGTCGGAGGGCTCGCCAGTTCCCACGGAGGCACAAGCGAACTCTTTTGAGTGGCACAAAATCGTATCTGATGATGAAGAGGACCTGGACAGTGACAGTGGGGAGGAATATCTGATGGATGAGGAGAACGACGATCCCGATCCCGGCAGAATCATTCTGAAATGGGATAATTCCAATACAATCACAGATGTTTCCTCGCGCCAAACGCGCTCCGCCAAAGTGGAATACAAGGACGAATCCGACCAGGAGGGTGACAACTGTACCATTGACCTGGATATGGATGTGGATATAGATCTGGATCTGGACAATCTCGACGAATCGTCGAAGAAACCACATTCCTGCCCGCACTGCCCCAAGACCTATCAGGAGCAGAAAACCCTGGATCGTCACATGGCACGTCAGCACAAGCCCGTGGATCCCGAGGTGGAAGCCGACTACGGGATGTGCCAGATACTTGATTCGAGGCCTCAGCCAGTGTACAAGTGTGATCAATGTGAGAATATATTTTTCACAAAGTTAATGTTGGTGGTTCATATGAACCGGAATCATAAGGTCAGACGCGAAGCCGCGATTTCGACCGCATCCCCGTCGTTCACTTGCGTGGAATGCGACTTAGAGCTGCCGCGCCTGCGTCTGCTCGACGAGCACATGCTGAAAGTACACGGCGGACCAGCGTGCGCGATCTGCAAACGGCGCTACAAAACGCGGCACGAGCTCAGGCGCCATCAGCTACGTCACAACAGCGAACGAAACGTGCCCTGCTCGCATCCCGGCTGCGAAAAGACCTTCTTCACCAAGCGCCACATGCGCAATCACTCCAAGGTCCACACGGAGGTAAAGAACTTTGTCTGCGAGAACTGTGGCTACAGCTGCCGCAACAAGGAGACGCTACGCGTCCACATACGCAGTCATACCGGCGAACGTCCGTTTGGTTGTAAGGTGTGCGACAAGCGATTCCCATCTCATTCTGGCCTGCGCGAGCATATGGCAATGCACTCGACAGATCGGCCATATGTGTGCAATGTCTGCAATGCCACCTTCTCCCGCCAGAAGGGACTGTACCATCACAAGTTCCTGCACTCGGATACGAAGCAATTTGTCTGCAAACTGTGCGGAAATGCCTATGCCCAGGCAGCCGGCTTGGCTGGTCATATGCGCAAGCATCGCAGCGAGGAGCTCAATGGTGGATCGTAG
Protein Sequence
MLKCLKADTYAGMANAKCGEIYFQSLDSFRIDCAFCEMKSFVFNDFLLHVQNIHFENGLLKTELKEEKELSEGSPVPTEAQANSFEWHKIVSDDEEDLDSDSGEEYLMDEENDDPDPGRIILKWDNSNTITDVSSRQTRSAKVEYKDESDQEGDNCTIDLDMDVDIDLDLDNLDESSKKPHSCPHCPKTYQEQKTLDRHMARQHKPVDPEVEADYGMCQILDSRPQPVYKCDQCENIFFTKLMLVVHMNRNHKVRREAAISTASPSFTCVECDLELPRLRLLDEHMLKVHGGPACAICKRRYKTRHELRRHQLRHNSERNVPCSHPGCEKTFFTKRHMRNHSKVHTEVKNFVCENCGYSCRNKETLRVHIRSHTGERPFGCKVCDKRFPSHSGLREHMAMHSTDRPYVCNVCNATFSRQKGLYHHKFLHSDTKQFVCKLCGNAYAQAAGLAGHMRKHRSEELNGGS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2