Dath005337.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila athabasca
Gene Symbol
ftz-f1
Assembly
GCA_008121215.1
Location
CM017796.1:47786057-47830020[-]

Transcription Factor Domain

TF Family
SF-like
Domain
zf-C4|SF-like
PFAM
AnimalTFDB
TF Group
Zinc-Coordinating Group
Description
The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 5 2 1.5e+04 -7.4 15.8 36 98 38 122 13 201 0.56
2 5 2 1.5e+04 -10.3 9.8 132 132 324 324 158 411 0.54
3 5 1.6 1.2e+04 -5.0 5.2 54 97 389 415 348 434 0.47
4 5 1.2e-19 8.8e-16 58.0 0.8 1 79 620 697 620 718 0.76
5 5 2.8e-70 2.1e-66 224.8 1.4 157 409 831 1076 816 1077 0.92

Sequence Information

Coding Sequence
atgtatagaaaAATGGACACCTTCAATGTACCTTTGCTGGCGgagagcaccagcagcagcagcaattatGCGTCTGCAGCAGTCACAGAGGCCAcaaccagcaccagcagccatcatcatcacctacagcatcaacatcagcaacagcagcagcagcaacagcagcagcagcagcagcagcaacagcatcttATGGCCCACCATCACAAGGATCAGATGCTGGCAGCGGGAAGTAGTCCCATGCTGCCGTTCCTCAGCTACTCTCAGctacagctgcagcagaaggATGCTAttgccaccagcagcagcagcggcagcaatgGTGGAACTGTGGCATCCGAAGGAGCAGAggtagcagcagcggcagcagcaattgCCACAGATAATTTTGATGGCAGCCAATTGGATGGTGGCATTTCTCTGAGCGGCCTCTGCGAGCGTTTCTTTGTGGCCAGTCCAAATCCTCATAGCAATAGCAACATGATCCTAATGGGCACCACCGCTCCGACAACCACAACAACTacccaaaacaacaacatcaacaacaatatcaacaacaacatcaacaataacaacaataaccATAACAATTTGGAGGCTAAAAACGGTACCAACCACACAGGTGGGGTGCAGCGAAGCGGAGGATCAGTTATTATCGAATCGGTGACCGTTCCCTCGTTTGCCAACATCCTGTTCTCCCATCGAACGTCTCAGGGCACAGCCGCCAACGAGTGCATCGATCCGTCGCTGCTGCAGAAATCCGTGCtacccagcagcagctccatcaTAGAATACCATCAGCTGAAACCCCTGGCCGAGAGTGCCACCAATGCGGGGGGGTCCGTTTCCACCACCAATTTTCTGTCCTCGAGCACCGCTCAGCTGTTGGACTTTGATGTGCAAGGCACATCCAAGGATGACAGTCATATAAGCACCACCACAACCATAGCAGTGGGAATAGGTTTGGGATCGGGCACGGGCACCGGTTCGGGCTCGGTCTCGGGATCCGTATCCGGATCCGGATCGGGTGcagcaacgacaacaacaacaacaatcactGCCAATCAGACAAGAAGTTCGTTGCACAGCATCGAGGAACTGGCTGCCAGCTCCTGTGCTGCACCCAAAGCCACCCCTCCATCAacaaatgggaatggaaacgGTAACGAGTATCACCACAGGACTACCACCAGTACAacgcatcagcagcagcagcaacagcagcagcagcatcacatGCAACAAAGTGGCAATCACAGTGGATCCAATCTCAGCACCGATGATGAGTCCGTTTCGGAGGATGAGTTCGGCCTGGAAATCGATGATCATGGAGGCTACCAGGACACCACCTCCTCCCACTCGCAGCAGAGCGGCGGTgggggcggcggcggtggcggagcTGGCGGCAACATCCTCAACGGCAGCTCGGGCAGCAGCTCTGGCTACATGCTACTGCCACAGGCGGCCAGCtccagcggcaacaacaatgccGCTCACATGTCCTCGGCCAGCGGATCCGTTGGAAATGCCAGCGGCCCCaacggtggcggcggcggcggttcCGGTCCTGGCAATGCCATGGGCGGCACGAGCGCCACCCCGGGACACGGCGGTGAAGTGATCGACTTCAAGCATCTCTTCGAGGAACTGTGCCCCGTGTGCGGCGACAAGGTCAGTGGCTACCACTACGGCCTGCTCACCTGCGAGTCCTGCAAGGGCTTCTTCAAGCGGACGGTCCAGAACAAGAAGGTCTACACCTGCGTGGCGGAGCGGTCGTGCCACATCGACAAGACGCAGCGCAAGCGGTGTCCCTACTGCCGCTTCCAGAAGTGCCTGGAGGTGGGCATGAAGCTGGAGGCTGTTCGAGCGGATCGGATGCGGGGTGGCAGGAACAAGTTCGGGCCCATGTACAAGCGGGATCGGGCGCGAAAGCTGCAGGTGATGCGTCAGCGGCAGATCGCCCTCCAGGCGCTGCGCAACTCGATGGGGCCGGACATCAAGCCGACGCCGATCTCGCCGGGCTACCAGCAAGCATATCCAAATATGAACATTAAGCAGGAAATCCAAATACCTCAGGTATCCTCACTCACCCAGTCGCCGGACTCGTCGCCCagtcccattgccattgcttTGGGCCAGGTGAATGCCAGCGCGGGAGGAGTGATAGCCACGCCCATTAATGCCGGAAACGGAGGCAGTGGcgccggcggcggcggtggcggcctGAACGGCCCCAGTTCCGTGGGCAATGGCAatagcagcaacggcagcagcagcaacaacaacaccggCAGCAGCACAGGCAACGGGGCAGGTGGCGCCGGCggaggcggcggtggcaacaatgcgggcggcggcggcggcaataACAGCTCCACCGATGGCCTGCATCGCAACGGCGGCGGAAATGGCAACTGCCACGAAGCTGGAATAGGATCTCTGCAGAACTCGGCCGACTCGAAACTGTGcttCGATTCCGGCACACATCCATCGAGCACGGCCGATGCGCTTATCGAGCCACTAAGAGTCTCACCGATGATACGAGAATTTGTGCAATCGATCGACGATCGGGAATGGCAGACGCAGCTGTTCGCGCTGCTGCAGAAGCAGACCTACAACCAGGTGGAGGTGGATCTCTTTGAGCTGATGTGCAAGGTGCTCGATCAGAATCTGTTCTCGCAGGTGGACTGGGCAAGGAACACGGTCTTCTTTAAGGATCTGAAGGTCGATGATCAAATGAAGCTGCTGCAACACTCCTGGTCGGACATGCTGGTCCTCGACCATCTGCACCATCGCATCCACAACGGGCTGCCCGATGAGACGCAGCTGAACAACGGACAGGTCTTCAATCTGCTCAGCCTGGGCCTGTTGGGCGTGCCGCAGTTGTCCGACTATTTCAACGAGCTGCAGAATAAGCTGCAGGATCTGAAATTCGACATGGGCGACTATGTCTGCATGAAATTCCTAATACTTTTGAATCCAACTGTACGCGGTATTGTCAACAGGAAGACCGTGTCGGAGGGACATGATAATGTGCAGGCAGCCCTGCTGGACTACACCCTCACCTGTTATCCTTCAGTCCATGAAAAATTCAGTAGGCTAGTGAACATCTTACCGGAAATCCATGCCATGGCCGCACGCGGCGAGGACCACCTCTACACCAAGCACGTTGCCGGCAGTGCACCCACCCAGACGCTGCTCATGGAGATGCTGCACGCCAAACGGAAGGGATAG
Protein Sequence
MYRKMDTFNVPLLAESTSSSSNYASAAVTEATTSTSSHHHHLQHQHQQQQQQQQQQQQQQQQHLMAHHHKDQMLAAGSSPMLPFLSYSQLQLQQKDAIATSSSSGSNGGTVASEGAEVAAAAAAIATDNFDGSQLDGGISLSGLCERFFVASPNPHSNSNMILMGTTAPTTTTTTQNNNINNNINNNINNNNNNHNNLEAKNGTNHTGGVQRSGGSVIIESVTVPSFANILFSHRTSQGTAANECIDPSLLQKSVLPSSSSIIEYHQLKPLAESATNAGGSVSTTNFLSSSTAQLLDFDVQGTSKDDSHISTTTTIAVGIGLGSGTGTGSGSVSGSVSGSGSGAATTTTTTITANQTRSSLHSIEELAASSCAAPKATPPSTNGNGNGNEYHHRTTTSTTHQQQQQQQQQHHMQQSGNHSGSNLSTDDESVSEDEFGLEIDDHGGYQDTTSSHSQQSGGGGGGGGGAGGNILNGSSGSSSGYMLLPQAASSSGNNNAAHMSSASGSVGNASGPNGGGGGGSGPGNAMGGTSATPGHGGEVIDFKHLFEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAERSCHIDKTQRKRCPYCRFQKCLEVGMKLEAVRADRMRGGRNKFGPMYKRDRARKLQVMRQRQIALQALRNSMGPDIKPTPISPGYQQAYPNMNIKQEIQIPQVSSLTQSPDSSPSPIAIALGQVNASAGGVIATPINAGNGGSGAGGGGGGLNGPSSVGNGNSSNGSSSNNNTGSSTGNGAGGAGGGGGGNNAGGGGGNNSSTDGLHRNGGGNGNCHEAGIGSLQNSADSKLCFDSGTHPSSTADALIEPLRVSPMIREFVQSIDDREWQTQLFALLQKQTYNQVEVDLFELMCKVLDQNLFSQVDWARNTVFFKDLKVDDQMKLLQHSWSDMLVLDHLHHRIHNGLPDETQLNNGQVFNLLSLGLLGVPQLSDYFNELQNKLQDLKFDMGDYVCMKFLILLNPTVRGIVNRKTVSEGHDNVQAALLDYTLTCYPSVHEKFSRLVNILPEIHAMAARGEDHLYTKHVAGSAPTQTLLMEMLHAKRKG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00514941;
90% Identity
iTF_00480913;
80% Identity
iTF_00480913;