Basic Information

Insect: Drosophila athabasca
Gene Symbol: fd59A
Assembly: GCA_008121215.1
Location: VMQQ01000020.1:150233-151719[+]

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 1.4e-40 1.4e-37 127.4 0.0 2 87 75 159 74 160 0.97

2 2 9.5 9.4e+03 -3.5 0.1 34 50 234 250 233 250 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	1.4e-40	1.4e-37	127.4	0.0	2	87	75	159	74	160	0.97
2	2	9.5	9.4e+03	-3.5	0.1	34	50	234	250	233	250	0.86

Sequence Information

Coding Sequence: ATGCACACCAGCACGGATCCCATGCACACTCTCCACGACAGCGTCTCCCTGTCGCCGCCGTTGCACAAGAGCCAGCggagtggcggtggcggcggcagtgcaTCCTCGCGAGCGGCCGCCGCGGATGCCATGTCCATGGCCTGTGACGACAGCGACATGGAGCCGTCGGCCATAGGTGGTAGCGGCGGAGATGGCTCTGGCAACACAGGCGGTCCATTGGTGAAGCCACCGTACTCCTACATAGCCCTGATCACCATGGCCATTCTCCAATCGCCGCACAAGAAGCTGACTCTCAGCGGGATCTGTGACTTCATCATGTCGCGCTTTCCCTACTACAAGGACAAATTCCCCGCCTGGCAAAACTCCATCCGCCACAACCTCAGTCTGAACGACTGCTTCATAAAGGTTCCACGCGAGCCAGGCAACCCGGGCAAGGGCAACTTCTGGACCCTGGACCCGCTGGCCGAGGACATGTTCGACAATGGAAGCTTCCTGCGACGGCGAAAGCGGTACAAGCGGGCCCCCACAATGCAGAGATTCTCCTTTCCGGCGGTGTTTGGCACCCTGTCCCCCTTCTGGATACGCAAGCCCGTGCCCCTGGTCCCGGTGCACTTCAATGTGCCAAACTTTAACGGAAGCCGTGACTTTGACGTGATGCACACACCCGCAGATGTCTTCGACACGGCGCTGCGGGCCGACAAGAAGTTCAATTTTTTCGCCAACGCCGAGGCTTCCCTTTACCAGAACAGCCAGAGTGGCGACAAGTTCGATCGCCTCTCCTTTATAAATCGCGCCCGGGCTGTGGATGCAACAGATGCCGGGGCCGTGGACTCCCTGCCCCACAGCAGTGGTGGAGCTGGGAGTAGAGCTAGCAAGTACAAAAGTCCCTACCCCTTTGATGTGGCGACTATGGCCAGTGCCGCCGCTGGAATTCCGGGTCACGGCGAATACGGGGAGAGAGTCAGTGCACCCGGCGGTGGATACATGGATCTCAATGTGTACAACGACGATGCGGAGGCAGATGCAGAGACCGAGGCGGAGGCAGACGACGATTCTTGCGAGGACAAGATCGATGTGGAGAGCGCCAACGAGAACGATCAGGAGGATTCGCACATATCGGACTCCGTGGACAGTGCGTGCACGAACCGTCTGGACGTGCCAGCGGAAGTGCTGCTTTTTGAGCATGCCGAGGCCTCCAGAAGCCCTATAGTCCAGGCCCTCACGTCCAGTCCAAGTAGCCGTTACGACGGAGAGCCGGCGAGCCTGCGGTCCATCAAGCAGAGCCACGCCAAGGACTTCCGCATAGAGACGCTCATCGGCCACCAGCACCGCCGTGCGGTCAGTCACGACGAGGCGAGTGACTAG
Protein Sequence: MHTSTDPMHTLHDSVSLSPPLHKSQRSGGGGGSASSRAAAADAMSMACDDSDMEPSAIGGSGGDGSGNTGGPLVKPPYSYIALITMAILQSPHKKLTLSGICDFIMSRFPYYKDKFPAWQNSIRHNLSLNDCFIKVPREPGNPGKGNFWTLDPLAEDMFDNGSFLRRRKRYKRAPTMQRFSFPAVFGTLSPFWIRKPVPLVPVHFNVPNFNGSRDFDVMHTPADVFDTALRADKKFNFFANAEASLYQNSQSGDKFDRLSFINRARAVDATDAGAVDSLPHSSGGAGSRASKYKSPYPFDVATMASAAAGIPGHGEYGERVSAPGGGYMDLNVYNDDAEADAETEAEADDDSCEDKIDVESANENDQEDSHISDSVDSACTNRLDVPAEVLLFEHAEASRSPIVQALTSSPSSRYDGEPASLRSIKQSHAKDFRIETLIGHQHRRAVSHDEASD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00600860;
90% Identity: iTF_00611203; iTF_00474317; iTF_00563700; iTF_00517516; iTF_00603155; iTF_00574612; iTF_00580510; iTF_00535859; iTF_00484251; iTF_00473587; iTF_00471413; iTF_00600860; iTF_00514695;
80% Identity: -