Basic Information

Insect: Drosophila asahinai
Gene Symbol: foxp1
Assembly: GCA_008042795.1
Location: VNJZ01011052.1:172459-174390[+]

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 2.3 3e+03 -1.4 0.1 14 51 26 60 21 69 0.69

2 3 4.6 6e+03 -2.4 0.0 7 33 154 180 152 184 0.85

3 3 5.6e-30 7.4e-27 93.5 0.3 2 81 328 401 327 408 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	2.3	3e+03	-1.4	0.1	14	51	26	60	21	69	0.69
2	3	4.6	6e+03	-2.4	0.0	7	33	154	180	152	184	0.85
3	3	5.6e-30	7.4e-27	93.5	0.3	2	81	328	401	327	408	0.94

Sequence Information

Coding Sequence: ATGCATCGGATACATGACGACGAATATTCTGAAGATGCCAAGGAAGCGGACTTTAAGGGATCCATTCTCCAGAAGGAAATAGCTGCGAAATCGCGTCACCAAATTTCCATTCCAGATATTTGCACGGAAGCTGTGAAAAATAACTGTTTTCAGCAATCTAGTTTTCTGAATAACTCGATAGCCTTTGCCCAGCACGTAGTAAAGTGTAGCTCTCCAGCCTCGAGCCTAGATGAATCGACATCTACGGCCCAGCACGAAACCAATCCCCACATGCACATCCAGGGCCAGCACATGATGGCGCCCGTTCCCGATCTTAGTTTTTACAACGTTCCCGAGTTCATCTCGGAGCAGGAGAAGCTTATGTTTTCGGATGCCGAGAGGTTCTTAAGGTCAAAGGATAACGAGGTGTGCAGTAATGACTACAGCTACATGCACGACGAGTTCGCCATGCGCAAGTATTATCATCCTCTATTTGCCCATGGAATATGCCGCTGGCCCGGCTGCGAAATAGACCTGGAAGATATAGCGTCGTTTGTCAAGCATCTAAATTCTGAGCATGGCTTGGATGATCGATCGACTGCCCAGGCTCGTGTCCAAATGCAAGTAGTTTCCCAGCTTGAGTCCCATCTTCAAAAGGAGAGGGATCGCTTGCAGGCCATGATGCATCACTTGTATCTGTCAAAGCAACTTTTATCACCCACTAAAATGGAAAGAAAGgatgTACCCAGTAGGGAGGGAAAGTTCTGCAGAAGTCCAATCACAATAAATAGCATAGGCCGACCCATGCGCCAAACAAGTTCACCTGGCGCCCTCAATCTTCCAATGGTTAATTCCACCAACTTATGTTCCATTAAGAAGAGAAACCATgacaaaaattcattttccaTTAATGGTGGATTGCCCTATATGCTTGAAAGAGCTGGTCTTGATGTCCAACAGGAAATTCAACGGAATAGagaattttacaaaaatgctGATGTACGACCGCCTTTTACTTATGCATCGCTTATAAGACAGTCCATCATAGATTCCCCCGACAAGCAGCTAACCCTTAACGAAATCTACAACTGGTTCCAAAATACTTTCTGCTATTTCCGCCGCAATGCAGCCACGTGGAAGaaTGCAGTTCGGCATAATCTGTCCCTTCATAAGTGCTTTATGCGTGTTGAGAATGTGAAGGGAGCTGTTTGGACAGTTGATGAAATTGAGTTTTACAAAAGAAGACCGCAACGCACCGCTGGCATTGGTAACAACTTAGCAGGTGCTACCAATTCGCCGGACACTAACTATTTTGTAGCTATGAACATTGGGTATGTGggttttaaatag
Protein Sequence: MHRIHDDEYSEDAKEADFKGSILQKEIAAKSRHQISIPDICTEAVKNNCFQQSSFLNNSIAFAQHVVKCSSPASSLDESTSTAQHETNPHMHIQGQHMMAPVPDLSFYNVPEFISEQEKLMFSDAERFLRSKDNEVCSNDYSYMHDEFAMRKYYHPLFAHGICRWPGCEIDLEDIASFVKHLNSEHGLDDRSTAQARVQMQVVSQLESHLQKERDRLQAMMHHLYLSKQLLSPTKMERKDVPSREGKFCRSPITINSIGRPMRQTSSPGALNLPMVNSTNLCSIKKRNHDKNSFSINGGLPYMLERAGLDVQQEIQRNREFYKNADVRPPFTYASLIRQSIIDSPDKQLTLNEIYNWFQNTFCYFRRNAATWKNAVRHNLSLHKCFMRVENVKGAVWTVDEIEFYKRRPQRTAGIGNNLAGATNSPDTNYFVAMNIGYVGFK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00596470;
90% Identity: iTF_00561562;
80% Identity: iTF_00531500;