Basic Information

Gene Symbol
RREB1
Assembly
GCA_035046425.1
Location
JAWNNY010000208.1:1597704-1603746[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.0052 0.45 11.3 0.6 1 21 237 257 237 259 0.96
2 13 0.0003 0.026 15.2 0.2 1 23 269 291 269 291 0.98
3 13 7.2e-05 0.0062 17.1 7.3 1 23 297 319 297 319 0.98
4 13 1.9 1.6e+02 3.2 3.7 2 19 550 567 550 569 0.97
5 13 0.0075 0.64 10.8 0.1 1 23 715 737 715 737 0.97
6 13 1.1e-05 0.00094 19.7 0.7 1 23 747 769 747 769 0.99
7 13 0.00074 0.063 13.9 2.0 1 23 775 798 775 798 0.97
8 13 0.0026 0.23 12.2 2.0 1 23 1070 1093 1070 1093 0.95
9 13 7.7e-05 0.0066 17.0 0.3 2 23 1457 1478 1456 1478 0.97
10 13 0.13 11 6.9 6.3 1 23 1484 1507 1484 1507 0.97
11 13 1.5 1.3e+02 3.5 2.1 1 23 1629 1652 1629 1652 0.91
12 13 0.0075 0.64 10.8 0.5 3 23 1719 1739 1717 1739 0.96
13 13 0.0057 0.49 11.1 5.7 1 23 1745 1767 1745 1767 0.99

Sequence Information

Coding Sequence
ATGCTGGcagcacagcagcagcagcagcagcagcacaataccagcaacaacaccaacacaaACACCACAGAGAACGAGATGGAGCGCCAGAGGCGGGACTCCACCACCTCGGAATCCTCGCTGGAGCACCTGGATTTGGGGCGCACGCCCAAAAAGCTCAGCGCAGTCAGCAGCGGCGTCGGCGgtagcggcagcggcagtcTGGTGCTGCAGCCGACGTCGACGCCACACGAAGTGGCGACAGCGACGTCGCGCAAACGTAAGCTGCGCCAGCTCCAACATCACCACCAGGACCTGCTCagcgacgaggacgaggaggaggaggaagcaTCAGCGCCCGGGGCCCGCCCCCACGGTCGCCAAAAGCAGCGACGCAACGCCAGCATCGTGCTGgacggcagcggcagcgacgCCAGTTCGCTGCGCAAGAAGTTCCGTTTAAATCGCTCGGCAGCTGCGGTGGCGGCTGTCTCCAGTCTCTCGGAATCGGGATTCGTGGACACCACCGGCCACAGCGGCTACTtgggcaacaacagcagctcagcgacagcgacgtcaacggcagcagcaactgcgaCGCAAtcggccagcagcagcaacagtagcagcggcagcagcagcgccggATCCGGTGGATCTTCGCCGCAAGGGGGCCTGTGCCTCTCCAGCGGCGAGTCCGGCATCGGGGCGGGGGACGAGCACATGAAGTACGTGTGCCCCATCTGCGAGGTGGTCAGTGCCACGCCCCACGAGTTCACCAATCACATTCGGTGCCACAACTACGCCAACGGGGACACCGAGAACTTCACCTGCCGCATCTGCTCCAAGGTGCTCTCGTCCGCCTCATCCCTGGACAGACACGTGCTGGTGCACACCGGCGAGCGTCCCTTCAACTGCCGCTACTGCCACCTGACCTTCACCACCAACGGGAACATGCACCGCCACATGCGCACCCACAAGCAGCACCAGGCGaaccagtcccagtcccagtcacAGTCCCAATcccatcagcagcagcagcagcagcagcagcagcgacgccAGCAACAGTCACATCctgcccagcagcagcagcaacagatgcagcagcagcagcagcaccacctccaccagcaACAGAGCCTCAATCCCGCCCAGCAGTCGCTGTCGGGTCGGGCGGAGAGCTACGAGAGCGATGCCAGCTGCTCCACAGATGCCTCCAGTGGTCATAGCCGCAGTCGCAGCAGCTCCTCCCTcacccacaacaacaacaacaactcgcAGAAGGCCAACCACAACCACAAGGACATGGAGCTGGacctggagctggaggaggaggtgaaGCATCACCACCAGAACCGTCGCGGCCTCAAGACCACCATCAATAACAATGTCATCGAGAGCGAGCacgagcaggaggaggaggaggaccagGATCACGACGATGTCGATGAGGAGGCGGATGTGGCCATGCTGACATCCACCCCGGATGTGGCCACTTTGTTGGCTGGTGCCAGTGCCTCGGGAGCTGCCTCCCGCTCTGTGTCCCCCTCGTCGGCCGCCTCGCCGGCGCTCCTGCTCAGCTGCCCCGCCTGCGGAGCCGGGGACTTCGAGACCCTGCCATTGCTGTGCGACCACCTGGACGCCCGGCACTCGGACATCCCGGCCAAGTGTCGTGACTGCGAGGTGATCTTCGCCAGCCACCGCCAGTTGCAGGCCCACTGCTGTCGTGGGGGACTAGGACGTCCAGTGGGAGTGGGACTGCCGCCTCTTCTGGGCGCCAGCAGCTCCCCGCTCCACGGCGACGACGATGCcgaggacgaggatgaggaggatgCGGAGCGACGTCTGCGGATGGAGAAGCAGCGCCTGGCCGACCAGCGCGAGGACTTCTTCCAGCAGCTCTACCTCAAGGGCAAGACCTCCGGCGAGCATCCGCCCTCGCCCATCAAGCACGAGCCGGCGGACAGCAAGGACCTGGCCGACATCCAGAGCATCCTGAACATGACCAGCTCCAGCTGCACCAGCAGCTTTCTGCGCAACTTCGAGCAGTCGGTGAACACGCCCAGCTCCAGCCAGTACAGCCTGGACGGTCgtgaccaggaggaggaggcccaGGATGCCTTCACCTCGGAGTTCCGCCGGATGAAGTTGCGTGGAGAGTTCCCCTGCAAGCTCTGCACCGCCGTATTCCCCAATCTGCGCGCCCTCAAGGGCCACAATCGTGTCCATCTGGGTTCAGTGGGTCCGGCCGGACCGTTCCGGTGCAACATGTGCCCCTACGCCGTCTGCGACAAGGCCGCCCTTGTGCGGCACATGCGCACCCACAACGGAGATCGTCCCTACGAGTGCGCCGTCTGCAACTACGCCTTCACCACCAAGGCCAACTGCGAGCGGCACCTGCGGAACCGGCACGGCAAGACCAGCCGGGAGGAGGTGAAGCGCGCCATCATCTACCATCCGGCGGAGGACGCCGGCTGCGGCGAGGACGGCAAGTCCCGGCTGGGCGAGGATCTGGACCTGAGCTTCCGCTCGATCAGTCCGACTCccccgccaccaccgccgccgctcCCGGAGAGCAGCTCCCAGCTGAAGCACATGCTCCTCGGCGAGAATCAGCCAGCGGGTGGATCTGTCGGAGGAGCAGCTGCCCCACAGCAGCCCCCGCTGAAGATCCAGGTGAAGAGTCTGGACCAGCTGGTGGACAAGAAGCCCAGCCAGGAGAAGAGCTCGCCCAGCGCCGCCCTGGACTTCAGCATGGACGTGCTGGATCTCAGCAAGAAGCCATCGAGCGGATCGGCGGCCATTACCCCGACACCCACACCGAATCCGGCTCCGCTGGTGCCTCCGCCGGGAGTGCCTGGCACCCCGGACTTGGCCGCCGccctggagcagcagcagttgctcctcgcccagcagcagctctTCGCCGGAGTCGCCGGTGATGCCGCCTCTCAGTATGTCCAGCAATTTTTCCGCAGCCTCATGCTCCAGTCCCAGAGTCCTGGCTTCTCGTACCTCTATGGTGCCTTCATGGccccgccgccgccgcaggCCAATCCGGAGAAGCCCCCACCGCTGGTGAGTCCGCCCACCCGGGGCCTGAACCCTCTGCCGATGGGCGGTGTGGGCGTGCCAGTGCCTCCGGGCGGGCCCGTCAAGATGGTCATCAAGAACGGCGTCCTGATGccgaagcagaagcagcgCCGCTACCGCACCGAGCGTCCCTTCGCCTGCGAGCACTGCTCCGCCCGCTTCACCCTCCGCAGCAACATGGAGCGCCACGTGAAGCAGCAGCACCCCCAGTTCTATGCCCAGCGCCAGAGGAGCGGCCACCATGTGATGCGCGGACGTGGCGCCTCCaacgccgctgccgctgccgccgccgcagctgctgccgctggcATGGGAGTTCCCGGCGTGTCATCCGCCGGAGTCGGTTCCGGAGCTCATCATCATCCCGGCCATGGTCACGGACACGGTCATGCCCCCATCTCGGAGCAGGTGAAGTACGCCATTCTGGCCCAGCAACTGAAGGCCCACAAGAACACAGATCTGCTGCAGCAGGCCCTGGCCCACGGATCGAGCAGTGTGTCCGGCAATCCCCTCCTGCACTTCGGCTACCCGCTGGCCACTCCGCCGCCCAACTCTGCGCTGCACAACGGCGGCAGCGGACAGACGGGAAACGGAGTGCCCATGGTCTCCATGGACGACGATGAGCCCAAGCTGATCATCGACGAGGACGAGAACGACAACGACGTGGAGGAGGTGGACGACttcgaggaggacgacgaggaggaggaggaggatgagccGGAGGACGAGCCCGAGATCATTGCCGACGAGGAGCCACTGCCAcgcgacgaggaggaggaccagCCGGAGGTCAAGATGGAGGAACTGGAACTGCCGAAGCCACTCACAGAGCAACTGCCTCTCGAGGCGGCCCAGAAGACCGCTGAGACCATCCTGGAGCAGGCCATCAAGGCGGGCAAGCCCATGACCACGCCCCCGCCTCCGGCGAAGGAGCAGCAACTGGAGCAGATCGCTCCGCCCGCTCCCAGCACCCtgaagacgatgatcgcccagGCGGAGTCCGTGGCCAAGTCCCTCAAGGAGGTGGCCAGTTCGCCCTTCAAGGACGAGTCGCAGGACTTGGTGCCGGTGGCCAAGCTCGTGGACAACGCCACCAGCCAGAACATGAGCTTCAACAGCTACTTCCGGCCCAGCGACGTGGCCAACCACATGGAGCAGAGCGACGAGGAGGGCCTGGTGGCCTCCGGCAGCGCCTCCGAGAGCAACAACAGCGGCACCGAGGACGTCAccagcagctcctccagcagcgaGCCGAAGAAGAAGTCCGCCTACAGCCTGGCCCCCAACAGGGTCTCCTGCCCGTACTGCCAGCGCATGTTCCCATGGAGCAGCTCCTTGCGCCGCCACATCCTCACCCACACCGGCCAGAAGCCCTTCAAGTGCTCCCACTGCCCCCTGCTCTTCACCACCAAGAGCAACTGCGACCGCCACCTGCTGCGCAAGCACGGCAACGTCGAGTCCGCCATGTCCGTCTACGTGCCCACCGAGGACGTCAGCGAGCCGATTCCCGTGCCCAAGTCCGTCGAGGAGAtcgagctggaggagcagcgCCGTCGCCAGGAGGCGGAGCGCGAGCGTGAACGCGAACTGGAGCGTGCCCGGGAGCGGGAGTTGGAGCGGGAGCGcgaactggagctggagcgcGAGCGGGAGCTGGccgagaaggagaaggagcgcGAACGCCAGCAGCTCATCCAGAAGTTGGCTGCCCAGatggccgccgccgctgctgtgGCTGCCGCTGTCCCCGGTACCCCGGGAGTCGTCACGCCCGGCGGACTAGATGCTCAAGCTGGCGGAGATCTGCCCTACAAGTGCCACCTGTGCGAGGGCTCCTTCGCCGACCGGCTGCAGTGCCTCGAGCACATCAAGCAGGCCCATGCCCACGAGTTCGCCCTGCTCCTCGCCAAGGGCGCCATCGAGAACGAGCCCGTGCTGGGCGAGTCGACTTCGGGGAACCCCAACCAGCCcccaccagccagccagcagccCCATTCCGACGATGAGGCCACCAACGGCGTGGTCGGTGGAGCCGGAGGCCGTGGCAAGTACCCGGACTACAGCAACCGGAAGGTGATCTGCGCCTTCTGCGTCCGCCGCTTCTGGTCCACCGAGGACCTGCGCCGCCACATGCGCACCCACTCCGGGGAGCGCCCCTTCCAGTGCGAGACCTGCCTCCGGAAGTTCACCCTCAAGCACAGCATGCTCCGGCACATGAAGAAGCACAGTGGACGTGCCCATAACGGCGATGCCCCCGGCTCCGACTGCTCCGATGATGAGCAGGTGAGCAGCAGCCCACCTGGCACTCCGGCTCCGCCCACATCCACCaccgccaacaacaacaacagctgccacaccaacaacaacaacaacaacacagtGAGCACCAAGCTGGGCCTGAAGCTGCCGAAGCTGCACGAGCTGCTGGACAAGGCGACGGAGTGGCGGGCCAGCCGGCTGGCGGGGGAGCACAAGGAGAACCTGGGCGAGGCGACGGCCCCCTCGGGCTCCAGCACGGATCTGATCGGGAATCTGTTGGGGATCAGCGACCAGGGCATCCTCAACAAGCTGCTCTCCTCGGCCGACGAGGCGGCCAAGCTCCTCGGGGTGGACAACAAATAG
Protein Sequence
MLAAQQQQQQQHNTSNNTNTNTTENEMERQRRDSTTSESSLEHLDLGRTPKKLSAVSSGVGGSGSGSLVLQPTSTPHEVATATSRKRKLRQLQHHHQDLLSDEDEEEEEASAPGARPHGRQKQRRNASIVLDGSGSDASSLRKKFRLNRSAAAVAAVSSLSESGFVDTTGHSGYLGNNSSSATATSTAAATATQSASSSNSSSGSSSAGSGGSSPQGGLCLSSGESGIGAGDEHMKYVCPICEVVSATPHEFTNHIRCHNYANGDTENFTCRICSKVLSSASSLDRHVLVHTGERPFNCRYCHLTFTTNGNMHRHMRTHKQHQANQSQSQSQSQSHQQQQQQQQQRRQQQSHPAQQQQQQMQQQQQHHLHQQQSLNPAQQSLSGRAESYESDASCSTDASSGHSRSRSSSSLTHNNNNNSQKANHNHKDMELDLELEEEVKHHHQNRRGLKTTINNNVIESEHEQEEEEDQDHDDVDEEADVAMLTSTPDVATLLAGASASGAASRSVSPSSAASPALLLSCPACGAGDFETLPLLCDHLDARHSDIPAKCRDCEVIFASHRQLQAHCCRGGLGRPVGVGLPPLLGASSSPLHGDDDAEDEDEEDAERRLRMEKQRLADQREDFFQQLYLKGKTSGEHPPSPIKHEPADSKDLADIQSILNMTSSSCTSSFLRNFEQSVNTPSSSQYSLDGRDQEEEAQDAFTSEFRRMKLRGEFPCKLCTAVFPNLRALKGHNRVHLGSVGPAGPFRCNMCPYAVCDKAALVRHMRTHNGDRPYECAVCNYAFTTKANCERHLRNRHGKTSREEVKRAIIYHPAEDAGCGEDGKSRLGEDLDLSFRSISPTPPPPPPPLPESSSQLKHMLLGENQPAGGSVGGAAAPQQPPLKIQVKSLDQLVDKKPSQEKSSPSAALDFSMDVLDLSKKPSSGSAAITPTPTPNPAPLVPPPGVPGTPDLAAALEQQQLLLAQQQLFAGVAGDAASQYVQQFFRSLMLQSQSPGFSYLYGAFMAPPPPQANPEKPPPLVSPPTRGLNPLPMGGVGVPVPPGGPVKMVIKNGVLMPKQKQRRYRTERPFACEHCSARFTLRSNMERHVKQQHPQFYAQRQRSGHHVMRGRGASNAAAAAAAAAAAAGMGVPGVSSAGVGSGAHHHPGHGHGHGHAPISEQVKYAILAQQLKAHKNTDLLQQALAHGSSSVSGNPLLHFGYPLATPPPNSALHNGGSGQTGNGVPMVSMDDDEPKLIIDEDENDNDVEEVDDFEEDDEEEEEDEPEDEPEIIADEEPLPRDEEEDQPEVKMEELELPKPLTEQLPLEAAQKTAETILEQAIKAGKPMTTPPPPAKEQQLEQIAPPAPSTLKTMIAQAESVAKSLKEVASSPFKDESQDLVPVAKLVDNATSQNMSFNSYFRPSDVANHMEQSDEEGLVASGSASESNNSGTEDVTSSSSSSEPKKKSAYSLAPNRVSCPYCQRMFPWSSSLRRHILTHTGQKPFKCSHCPLLFTTKSNCDRHLLRKHGNVESAMSVYVPTEDVSEPIPVPKSVEEIELEEQRRRQEAERERERELERARERELERERELELERERELAEKEKERERQQLIQKLAAQMAAAAAVAAAVPGTPGVVTPGGLDAQAGGDLPYKCHLCEGSFADRLQCLEHIKQAHAHEFALLLAKGAIENEPVLGESTSGNPNQPPPASQQPHSDDEATNGVVGGAGGRGKYPDYSNRKVICAFCVRRFWSTEDLRRHMRTHSGERPFQCETCLRKFTLKHSMLRHMKKHSGRAHNGDAPGSDCSDDEQVSSSPPGTPAPPTSTTANNNNSCHTNNNNNNTVSTKLGLKLPKLHELLDKATEWRASRLAGEHKENLGEATAPSGSSTDLIGNLLGISDQGILNKLLSSADEAAKLLGVDNK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00504177;
90% Identity
iTF_00481716;
80% Identity
-