Basic Information

Insect: Drosophila anomalata
Gene Symbol: MBD-R2
Assembly: GCA_035046425.1
Location: JAWNNY010002187.1:1697510-1701301[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 1.2e-22 4.1e-19 68.1 0.1 4 76 456 526 453 527 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	1.2e-22	4.1e-19	68.1	0.1	4	76	456	526	453	527	0.93

Sequence Information

Coding Sequence: ATGGGCCGCCGATGCTGCGTGGCCAACTGTCCTTCGACGTCGCGTCTTCTGGAGCACCACGGCGTCACTTACCATTCGTTTCCCCTTGACCCCGTCATCCGTGCCATTTGGATCAAGAACTCCCGAATCAGCCTCGGCCGCCAGATCACGAAAAGCGTGCTTGTCTGCTCGCGGCACTTTCGCCGGCTGGACTTCAACACCATCCGCAATGGCAAGTACCTGCTGAAACCGCGTGTCTTTCCAACAGTGTTCCCCTGGGGCAAAATGGATGCCTCCGAGATTGAGGCCGATCACCGGGCGCTGCAGCAGGCCAATGTAGAGGGTGCGGTCAACCAGGGCGCAGCCCACACCTCCACCAACGAGGACGTAATCAAGGCCACTGTAGACCAGATTGTGGCCCAAATATTGTCGGAATCAGCAGAGCGCAGTGCCGCGGAAGCttctaaaaaggaaaaagaaaaggaagccCCGACTCAGACCTCACCACCAGACTCCAGCAGCACACCCAAACAATCATCGGTCGAAGAGACGGCTGCCCCTACTCCGTCTACTCCATCAAGCAGCTCGGCTGCTTTGCCCAACACCGGGGGCTCCAGCTCCAATTCGCCGTTGCCAGCTTCGCCAGTCAAGTACAGCAATCCCACGAACCTGACCATCGGAGCTCGCTTGGAGGCTCTTAACGCGGAGGGCAACTGGATGCCGGCCAGGATCGTGGAGGTAAACGAAACCGAGCAGACACTGCTAGTTCGCTTCGAACGCAACCACAAACAAAAGACCTCGCCGTCCACGAGCGGCGGCTCCCAGGAATGGATGGCCATCAAGTCGGAAAAACTCCGCCAGCGGCTCAGCAATCGGGTATTGCCCGTTTTTGCACTGGACGAGAAGTGCATGGCCCGCTGGTCGGGGCCGCGCAAGTTCCCCGGTACCGTGCGCAAGCTGCTTGGCAACGATACCTACGAGGTACTCTTCGACGACGGATACATCAAGAACGTTCGAGCGGTTCACATGAACAAGTTGCCCAGGCAGCAACTGCCACCTGCTGAGGCAGCCGaaagtgcatccaccaacgCAGAAGTGGCAGGAGCAGCTGCTGTACCTGCTCCTGGAACATCAACAGCAGTGCTGCCTCAGGCTGTGAAGAGGCCAAGTACTGGCAGCATTCCCAGCTCCGTCTCTACCAGCAAGAAAAGCAAGTCCACACCCCAGCGCAAGGATTGGCCTCTGTTGGATATGTCTAGTCTGGATTTGGTTGCTCTGGGACTTCCGGATATTCCACACGACGGAGAGTGGACGTGCCATTGGGTTAACGACCAACCCATTGGCACCGAAGGTTTCCTAATCGTTGGCGAGCACCAGAAGCCTACGGTTATTGTGGAGGACTGGCGACTGCCTCCCGGCTGGATCAAGCACATGTACCAACGCTCCAATGTGCTCGGAAAGTGGGACGTTATTCTGGTCTCTCCCAGCGGCAAACGGTTCCGCTCCAAGTCCGACCTGAAGGTTTTCCTCGAGTCACAGGGTCAGATCTACAACCCAGACGTCTACGATTTCAGCATTCACCGAAGAAGAGCTAAGGACATAAACGCCTATGTCTACACTCACGATTACAATCCACAGCCGCCGCCAAAACCGAAGCCGATGGATGTTTCCCTCGACTCGACACTGGATCAGAGCAACACCACATTGTCCTCGCTGCCCTCGACCCCGTTGCCCGTGAAGGACAGTCAGTACATGGAAGCGCCAGTGGCTTCGCTAGTGCCGCCTGCAGAGCTTATGTCGCCTCAGGCTCAGGTCGGAGATGACCCCAAACCCAAAACGACTCCAGAACTTTTGGAGGCAATAGAGGGCAGTGCCGGTTTGAGCTTGGAAGGTGATCCAGGCTTGGTCGAAAATGGATTTGCTTTTATTGGTGGTCTGAAAGTTCAGATACAGGAGAACCTGTATGTTTGTCCCCGCGACGGCTGTGGGAAGACCTACCGCAAGGAAGACTTTCTGCTGATTCATATTCGACACTACCACAAGGAGTTTGCCGAGTATGTTAGTCACTGCCCAAAGATGCAGGAATTGGCGGTAAAACGCACGCACGCCTCTTCTATCGAGCAGGGTGATGGGGCgcccaaaaaccaaataccCAATCAGCAGTTCTTCGCCAAGATGCACCAACAGGACGTACAGCAGTCGCGCACGTTAAAACGCCAAGCTCTTCCAGTCGCAGTCACGCCACCTAGACCCTCTGGCACTCCCCCTGTAGTTTCCCCTGCCAAGGCAGTAGTTTCGCCCAAGCAAGAGCCCTTGGGTCCCGTGACCCCCGCGGTCGAGAACACCaatattacagaaaataagTCTCTGGAGCCAGCTCCAAGTCTTCCGCTGAGCTCCGCCGCTCGGTCCAGCAAACGAGCTCGCTATTCACCCACCAAACGCCCTTCAGGGTCGCGGAAAAGTAATCGACAGCGCACCCAGCGTCGCAGTAATTTGACGGACAGTCCTGGCCAGAATCCAAGCGAGCATGACACCGAAGATACAAGGCTGTCCTTCAACACGCCCACATCCGATCTTCGCACCGACTCCAAGAAGAGACGCATGGGACCTGCTGGCACTCCAATCAGTTCCATTGATTCCCCCGCTACAGCGGACTCTGGATCGACGCCGTCATCCAATGACCAGGTGGATATCAATGCCGCTTTGGCGCCACCGCCTGCAAATACGCTTGGAAAAGCGCCACAATACATCAAGGAGAATGGAGAACTTATACGGATAGTCCGTATGCGGCAGGAGGAGATCATTAACTGCATTTGCGAATACGGCGAAGAGGATGGGCTCATGATCCAGTGCGAGCTGTGTCTCTGCTGGCAGCACGGCGCCTGCAACGGCATTATCAAGGAGGCCGACGTTCCAGAAAAATACGTTTGCTACATTTGTCGCAATCCGCAGCGCGGACGGGACTCAATGCGGTTCAAGCACGACCAGGACTGGCTCTTTGAGGGCAAGCTGCCTTCGGCTGCGTATCATACTTCGAATCCGCAGGCCTTCAAACAGGCTGACATGTTGAAGCGCTCCCACACACTTACCGGCAATCTCCTGGACGCCAAGCGCTCAATGCACTCGCTGCAGGTCAAGATCAACATTGCTCGCAACAGATGCCATCCGAAACTGTATTTGTGGGCCAAGAAGTGGGACGAGGACCATGTAGATGGCACTGCAGTGACACCAATTAAGCGCCCAAAGTCGGAGAATACTCAGGACTTCCCGCATATTCCCCAGCCTGAGGCAGCTATCGATCCAGAAGAGTGCCAATACCGTCTGATAGAGCACGTGAAAGTGCAGCAGGCCCTAATTTTGAACCGACTTAATGACATCGAGGCGGAAATGGATGAGCTCGAAAAAGACGACAGCCTTGATGACTTGAAGAATAACGACGATATCTCGACGACCAAAGAAGCTATGGCCACGTTCATCAAAGAGCTCGAAACTTTAAAGCGGCTCGCGCGCCTGAACCAAGTGGCCAATCTGAAGCAGAGCCTTAAAGATCCCGTAACCAATCCTCCAGCTTGA
Protein Sequence: MGRRCCVANCPSTSRLLEHHGVTYHSFPLDPVIRAIWIKNSRISLGRQITKSVLVCSRHFRRLDFNTIRNGKYLLKPRVFPTVFPWGKMDASEIEADHRALQQANVEGAVNQGAAHTSTNEDVIKATVDQIVAQILSESAERSAAEASKKEKEKEAPTQTSPPDSSSTPKQSSVEETAAPTPSTPSSSSAALPNTGGSSSNSPLPASPVKYSNPTNLTIGARLEALNAEGNWMPARIVEVNETEQTLLVRFERNHKQKTSPSTSGGSQEWMAIKSEKLRQRLSNRVLPVFALDEKCMARWSGPRKFPGTVRKLLGNDTYEVLFDDGYIKNVRAVHMNKLPRQQLPPAEAAESASTNAEVAGAAAVPAPGTSTAVLPQAVKRPSTGSIPSSVSTSKKSKSTPQRKDWPLLDMSSLDLVALGLPDIPHDGEWTCHWVNDQPIGTEGFLIVGEHQKPTVIVEDWRLPPGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKVFLESQGQIYNPDVYDFSIHRRRAKDINAYVYTHDYNPQPPPKPKPMDVSLDSTLDQSNTTLSSLPSTPLPVKDSQYMEAPVASLVPPAELMSPQAQVGDDPKPKTTPELLEAIEGSAGLSLEGDPGLVENGFAFIGGLKVQIQENLYVCPRDGCGKTYRKEDFLLIHIRHYHKEFAEYVSHCPKMQELAVKRTHASSIEQGDGAPKNQIPNQQFFAKMHQQDVQQSRTLKRQALPVAVTPPRPSGTPPVVSPAKAVVSPKQEPLGPVTPAVENTNITENKSLEPAPSLPLSSAARSSKRARYSPTKRPSGSRKSNRQRTQRRSNLTDSPGQNPSEHDTEDTRLSFNTPTSDLRTDSKKRRMGPAGTPISSIDSPATADSGSTPSSNDQVDINAALAPPPANTLGKAPQYIKENGELIRIVRMRQEEIINCICEYGEEDGLMIQCELCLCWQHGACNGIIKEADVPEKYVCYICRNPQRGRDSMRFKHDQDWLFEGKLPSAAYHTSNPQAFKQADMLKRSHTLTGNLLDAKRSMHSLQVKINIARNRCHPKLYLWAKKWDEDHVDGTAVTPIKRPKSENTQDFPHIPQPEAAIDPEECQYRLIEHVKVQQALILNRLNDIEAEMDELEKDDSLDDLKNNDDISTTKEAMATFIKELETLKRLARLNQVANLKQSLKDPVTNPPA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00615598;
90% Identity: iTF_00481573;
80% Identity: iTF_00477368;