Basic Information

Insect: Drosophila americana
Gene Symbol: zfh1
Assembly: GCA_018152915.1
Location: JAECXQ010000444.1:22050030-22054190[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 3.3e-05 0.0019 18.2 1.1 1 23 150 172 150 172 0.97

2 15 0.00079 0.046 13.9 1.2 3 23 180 200 178 200 0.94

3 15 8.6e-05 0.005 16.9 0.1 1 23 356 378 356 378 0.98

4 15 0.0003 0.017 15.2 0.9 1 23 384 406 384 406 0.98

5 15 3.3e-05 0.0019 18.3 2.2 1 23 437 460 437 460 0.95

6 15 0.00054 0.031 14.4 1.9 1 23 492 514 492 514 0.95

7 15 0.017 0.98 9.7 1.3 1 23 520 543 520 543 0.97

8 15 0.025 1.5 9.2 0.4 3 19 552 568 551 569 0.95

9 15 0.00015 0.0087 16.2 5.6 1 23 578 600 578 600 0.97

10 15 0.039 2.3 8.6 1.2 2 23 606 627 605 627 0.96

11 15 8.8e-06 0.00051 20.1 1.0 1 23 636 658 636 658 0.98

12 15 0.00099 0.058 13.6 0.1 3 23 666 686 664 686 0.97

13 15 5.3e-05 0.0031 17.6 0.5 1 23 692 714 692 715 0.95

14 15 0.051 3 8.2 0.4 1 23 725 747 725 747 0.97

15 15 0.0015 0.088 13.0 0.3 1 23 1243 1265 1243 1265 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	3.3e-05	0.0019	18.2	1.1	1	23	150	172	150	172	0.97
2	15	0.00079	0.046	13.9	1.2	3	23	180	200	178	200	0.94
3	15	8.6e-05	0.005	16.9	0.1	1	23	356	378	356	378	0.98
4	15	0.0003	0.017	15.2	0.9	1	23	384	406	384	406	0.98
5	15	3.3e-05	0.0019	18.3	2.2	1	23	437	460	437	460	0.95
6	15	0.00054	0.031	14.4	1.9	1	23	492	514	492	514	0.95
7	15	0.017	0.98	9.7	1.3	1	23	520	543	520	543	0.97
8	15	0.025	1.5	9.2	0.4	3	19	552	568	551	569	0.95
9	15	0.00015	0.0087	16.2	5.6	1	23	578	600	578	600	0.97
10	15	0.039	2.3	8.6	1.2	2	23	606	627	605	627	0.96
11	15	8.8e-06	0.00051	20.1	1.0	1	23	636	658	636	658	0.98
12	15	0.00099	0.058	13.6	0.1	3	23	666	686	664	686	0.97
13	15	5.3e-05	0.0031	17.6	0.5	1	23	692	714	692	715	0.95
14	15	0.051	3	8.2	0.4	1	23	725	747	725	747	0.97
15	15	0.0015	0.088	13.0	0.3	1	23	1243	1265	1243	1265	0.98

Sequence Information

Coding Sequence: ATGAACAATCAGGACTATGGCGGCATCCAATGGATACAGCAGCACGCATCTGCGGTTGATTCCGAAACAGATATGCTGGAAAACGGCGCTGCTGACAGCGAGGTGACTGCCGCCTATTTGGTAAATGGCAATGCAACGGACGAGGATCTTGACCATATGGCGGCCGAGAATCTTATCTTCATGGCGCGCGATGGTCAGCTAAGCGAAATCATAGCCGCCAACGAAGCCGGCGGCGGAACTGTATTAATCACGGACAGCGGCACCGTTGCCTATGCCGAGTCATTTGATGATGATGCACAGGTGGTCACCGAGGAGATCATTACCGATGATTGGGTGCAGCATCAGGGTGCCGAGCGCGTGGAAATCGCCGCGGAGCAAATTGCGGGCAACAATAGCTCGCAGGAGCTGCTGGACATGGAGCAGGATGAATATACGGCGCTGCGCCCCTATCCCTGCGACTTTTGTAGCCGACGCTTTCGCAAAAAGGGCAGCCTCAATACTCACATGCTGGCGCACCAAAACGATCGTCCACATCTGTGTAAATTGTGCGGCGCACGTTTTTCAAGGCGTGCCGAGCTCATCAGTCACTTCAAGGCGCATGCCGAGGCACAGGTTGCGGCAGATGAGGCGGCTGCAATTAAATTTGAGCCGCAGCAGCAGCAACGCCAAGCGGATGATCATTATTACGAACAGGATTGGCCTTTGTACCAGGAACAGGAAGAGGATCAGGTGCAAGACCAGATGCAGCAAATGGAGCAGGAGCAGCTGGTGGAGCCGCAGGCCAGCTATGCAGCGGTTAGCGCTGTGTCCGCACCAACAGCCACGCGCGGCCGCATCAGCCGCCTCAAGCCCAAAGAAGAGAGCACGCAGTACATTGTGATTGCCGAGAAGCAGACAACAGACAACGATTTGCGCCAGTACATGGATTGCGAGGAGCTGCCGCTGCAGCCGCCGCTAACTGGCAGCACGTCAATCGATGCATCGCATTCGACAGAGTGTCCAGACGGATCCGGCGCCGATGCGGCGCAGACACTACGCTTTCCGGTGCTGGACGAGAGCAAGCCCTTTGTGTGCCAGCAGTGTGGACTCGCATTTGCGCGCGAAAAAGCGCTCGTCTCGCATATCAAGAATCATCGCGTGGACTCGCCCTTCGAATGTAATCAGTGTCAGGAGATGTTCTGGGATAATTACAGCCTGCAGGAACATCAGAAGACACATCAGTTCGAGGAGAGCAACTCGGAATATGATCCAGCTTCGGCGGGCGAAGATAGCGCCAGCGAATCGGAGCCGGATCAGCTTTACGGTGACTTCTACTGCAGCGAGTGCGGCATTTCCTTTCACAGGCAGGACCTGCTGCGTCGTCATGCCAAGCAACAGCACAAACTGACACCAGACACGGATGGCGGCGACGGCGGCGGCGAAGGTGACGGCGGTGGCGGCGATGCTGATGCCGAAAATGCCAAAGACGCCGCGCACTGTTGTCACACATGCGGCAAATCGTTTCCCAGCGCACTGGAGCTGCTCGCCCATGCCGAAGTTCATGCACGCTTCCCGCCATTCAAATGCGTCCTGTGCGGTGTTAGCTTTTACGAGGAGCAGGCTATCAAGCGGCATTTGCACACGCGCCATCCGCACGAGCTGAAGCCCAACTCGTGCGTGCTGTGCGGCAAAGAGTGTCGCGATCGCAAGGCACTGATCAAGCACGCCTGGGATCACTCGCGCGAGAAGTGCCACTCGTGCTCCAAGTGCGGCAAGAACTTTCACAACAAGGCGCGCCTGAAGCGACACATGGCCTCGCATCGCGACAAGTCGGTGGTTTGCGAGGTGTGCCACGAGGAGTTTCCCGATGGACGCACGCTTTCCAATCATCGCCATTCACATAGCACCACATCGCCGGGCAAGCTGTTTCCCTGCCACGAGTGTGGCAAGACCTTTGGCTCGCGCAGCTCGCAGCAGATACATGTCCGCATCCACACAGGCGAACGGCCATATGGCTGTCGCTACTGTTGGAAGGCGTTTGCCGATGGCGGTACGCTGCGCAAGCACGAACGCATTCACACGGGCGAGAAGCCCTACGCCTGTTCCGTGTGTCCGCGTGCCTTCAATCAGCGCGTTGTGCTGCGCGAGCACATACGCTCCCATCACTCGGGTCTGGATGCGGTACGTGGCACCTATCATTGCACCGTCTGCTCGGCCGATTTGTCCTCATCCAATGAGCTTATACAGCATCTCATCCAGCACAGCGACACGAACACCGCCAAACAGCGACAGCCAATTACTGGTCCGCGCAAGTATAAGCGACGCAGGAAACTACAGCCACACGAGATTGCCCACATGCGTGCGGGGACCAAGGATGGCGAGGAGTATGCCAGCGATATGGAACTATGTGACTTTGATGTTGAGAACGTGGATGAGCTCCTGGACAGGACGGAGCCACTGCCAACCAAAAAGGAGAAGCGCAAGCGAGCAGCTGCAAATCAAGCTAAGGCCGTGACCAATGGCGCCGCACACAATAGTTCCAGTTCTGCCAAATCCGCCAATAGCAGCTCGGAACGTCTGTGGGATGAGAAATTCCTGCCGGCAAACAGCAATGGCAATGTTGGCAACGCAGATGATGCCTACAAAAGCTTCTTTCAAATTGATTCGCTGGTCGTGGTAAATGATACCACTCTGCCGCCTGTAAGCTCATCCAGCAGCACACCAAGCGCCTCCAAGTCGCGACGCGGCGGCAAGCAGCCACCGACGCAAACGCAGGCCGAGAGTAGTGACAAGTCTAAGTCTAGTAAGGCGGCCAAGAATACAGGCACAGCAGCTGCCACATCAAGCAGTTCACGTCCCCGCATGATACACACAGAAAAGGCACGTGTGCCGCCAGAGAATGCCAGCAAAAAGTCGCGTGGGCGCAGCTACATAACGCGCACCAGCACCAGCGAGAGCAGCCAGCTGGGCCTGGTCAAGTCGAGCGGCGTGGCCAGTTCACGGATTGTCGATGATTACGAAATTATATCACCTGCCACACAGCCGCCGAATCAGATCAGCTCCAGTCCGCTGCACATCAAGCAGGAGCAGGAGCAGCAACAGCAGCGCGTCCAGCTCATGTACGATGACACCCATTTGCTGATCCATGCGGCCATGTTGCGCGATAAGCCCTACGACAAGTTCAATCCGAGCATTGTCAATGATCTGGAGGAGATATTACGCAGTCCGCTCAAGCATGATCGGAATGCGCGCCTGCGTTTCACCAGCGAATCGTCGACAACGCCACAGTTTCTGCCCGAGGAGGAGCAGAACCTCATTAAAATTGAGCCCACGTCGCCGGATCTGCGCGAAATGGTGGAGAGCCAGCAACGTGTAACTGCCACAGGACACACAGCCACGCCCACATCATCATCCTCATCGTCGGCGCGCACATCGCGTCATCTGCGACAGATCACTGCCAACTCGGCCACCCGCTCGGCAGCCAAGCGGCACATGGACAAAAGCTCTTCGGAGTTCAGTGCCAAGAAATCGACAACATCCTCGCCCGTTGCAGTCAGTAAGCCAGCCGCCAGTTCGTACCTCAGCTATGGCGTGGACTCGTACAATGTGAATGTGGTGGCCAGTGCCAACTCTTCGGATGTCAGTTCCGGTTTCTTTTCCATCTCCGAGGTGGTATCCGCTGCACATGCCGCCGATGCAGCGGCCAAGGCAGCAGCGGCCAGCAAAACGGAACGTCGGACGCGCTGCTTTGAGTGTGAAATGTGTTCATCCATATTTCCGGATCGCGCCCAGCTGCTGGAGCACATGCATATACACATCTGA
Protein Sequence: MNNQDYGGIQWIQQHASAVDSETDMLENGAADSEVTAAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANEAGGGTVLITDSGTVAYAESFDDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNNSSQELLDMEQDEYTALRPYPCDFCSRRFRKKGSLNTHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADEAAAIKFEPQQQQRQADDHYYEQDWPLYQEQEEDQVQDQMQQMEQEQLVEPQASYAAVSAVSAPTATRGRISRLKPKEESTQYIVIAEKQTTDNDLRQYMDCEELPLQPPLTGSTSIDASHSTECPDGSGADAAQTLRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNYSLQEHQKTHQFEESNSEYDPASAGEDSASESEPDQLYGDFYCSECGISFHRQDLLRRHAKQQHKLTPDTDGGDGGGEGDGGGGDADAENAKDAAHCCHTCGKSFPSALELLAHAEVHARFPPFKCVLCGVSFYEEQAIKRHLHTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAVRGTYHCTVCSADLSSSNELIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAGTKDGEEYASDMELCDFDVENVDELLDRTEPLPTKKEKRKRAAANQAKAVTNGAAHNSSSSAKSANSSSERLWDEKFLPANSNGNVGNADDAYKSFFQIDSLVVVNDTTLPPVSSSSSTPSASKSRRGGKQPPTQTQAESSDKSKSSKAAKNTGTAAATSSSSRPRMIHTEKARVPPENASKKSRGRSYITRTSTSESSQLGLVKSSGVASSRIVDDYEIISPATQPPNQISSSPLHIKQEQEQQQQRVQLMYDDTHLLIHAAMLRDKPYDKFNPSIVNDLEEILRSPLKHDRNARLRFTSESSTTPQFLPEEEQNLIKIEPTSPDLREMVESQQRVTATGHTATPTSSSSSSARTSRHLRQITANSATRSAAKRHMDKSSSEFSAKKSTTSSPVAVSKPAASSYLSYGVDSYNVNVVASANSSDVSSGFFSISEVVSAAHAADAAAKAAAASKTERRTRCFECEMCSSIFPDRAQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00582391;
90% Identity: iTF_00563313;
80% Identity: -