Basic Information

Gene Symbol
VEZF1
Assembly
GCA_035041765.1
Location
JAWNKY010002018.1:2816505-2821128[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 26 0.0018 0.15 12.7 1.1 1 23 215 237 215 237 0.96
2 26 0.031 2.6 8.9 1.7 1 23 243 265 243 265 0.97
3 26 0.049 4.1 8.2 2.4 2 23 297 318 296 318 0.97
4 26 0.0025 0.21 12.3 2.8 1 23 391 414 391 414 0.94
5 26 3.1 2.6e+02 2.6 1.3 2 22 422 442 421 442 0.95
6 26 0.52 43 5.0 1.5 1 23 451 473 451 473 0.97
7 26 0.32 26 5.7 0.5 3 23 485 505 484 505 0.97
8 26 0.016 1.3 9.8 0.8 1 23 587 610 587 610 0.97
9 26 0.0037 0.31 11.8 0.2 2 22 620 640 617 640 0.90
10 26 4.7 3.9e+02 2.0 4.4 1 23 649 672 649 672 0.95
11 26 0.0011 0.091 13.4 1.6 2 23 698 719 697 719 0.97
12 26 8.7e-06 0.00072 20.0 2.5 1 23 727 749 727 749 0.99
13 26 0.0042 0.35 11.6 1.9 1 23 901 923 901 924 0.95
14 26 0.027 2.2 9.1 0.4 2 22 932 952 931 952 0.95
15 26 0.039 3.3 8.5 0.6 1 23 961 984 961 984 0.90
16 26 1.8e-05 0.0015 19.1 1.2 2 23 1007 1028 1006 1028 0.97
17 26 0.00014 0.011 16.3 1.2 1 23 1035 1057 1035 1057 0.98
18 26 0.029 2.4 9.0 0.0 2 21 1084 1103 1083 1104 0.93
19 26 0.012 0.97 10.2 3.9 1 23 1150 1173 1150 1173 0.96
20 26 0.0066 0.55 11.0 0.5 1 23 1210 1233 1210 1233 0.96
21 26 0.00028 0.023 15.3 1.5 1 23 1257 1280 1257 1280 0.97
22 26 5.4e-06 0.00044 20.7 0.2 2 23 1308 1329 1307 1329 0.95
23 26 0.00015 0.012 16.2 2.9 1 23 1335 1357 1335 1357 0.99
24 26 3.6e-06 0.0003 21.3 2.0 1 23 1363 1385 1363 1385 0.97
25 26 1.9e-07 1.5e-05 25.3 2.4 1 23 1391 1413 1391 1413 0.99
26 26 0.0013 0.1 13.2 0.1 1 21 1419 1439 1419 1443 0.91

Sequence Information

Coding Sequence
ATGCTGCCCAGCAATATTTGCCGGACGTGTGCCCAGCAGAATACCAATTTGCTGCCCCTTTCCACGTCCTTGGACAAGTACACGAACAAAAGTTTCTATGATGTGCTCCAAGAACTGACACAGATCGATCCTCTGTTGGAGAATGCGGACGACAATCTGCCCCAGCATCTGTGCACAGATTGCTTGGGCAGGCTGGAGAATGCATACGCCTTTGTAGAGCAGGCAAGAAAGGTCAATGGAGAGCTGCTGGTGCGGCTGCGGGAATGTCTGGAGGAGAGCCCCATTGACATACCACAGCAGCAGATCAAAACGGAGATCGACATTGATGAGGAGCAAAGAGATTTCACAGATTCAGGCGAGGCACAAAGATCGtctgatgtggatgtggagtcGGCTGGCGTGTGCTCCGTTGAGCTGAAATGGACTCCAGAAAGCGCCAGCGAGGAGGAAAATGCTGCCGATGCACTCTTAAACGATGAAGATGATGATGCGCAGCCCTATATCTTGCGGCGAAGTCCCCGCAAAGTCAAGCAACAGGCAGACAGTGAAGAGGAGGATGGAGTCAGTCCTTCACCCAACAAGCGGCGTCGCGGGCGTCCTCCTGGTCTGGCCAAAAGCCAGTCAAGGAATTCCGAAGGCCGTCATGCTTGTGAGGTGTGTGGCAAAACGTTTTCCTGGTTCCGGGACATGAAGCGACATGCGCGCGTCCATTACGAGAAGGCATCGTTCGTCTGCGATACTTGTGGCAAGGGATTCCTGCGCAAGGACAAGTACACTTTTCATCTGCGCTCCCACGAGAAGCGGGAGGCCAAGTACCAGGCCCTCCAGCTGAAGAACGAGTGGAGGTTCGCCGAGCGTTTGTACAGCTCTGGACGATTGAAGAGAATGCAGTGCAAATTGTGCGGCTTGAAATGCCAGCGAATGCAGGAGCTTCGATCCCATTTGGAGAGCCACGTCCACACGGACAGTTTGTTCAGTCTGCGAGCGGACAACGATGTGGTCAAAGAACATTTTGCCACTGGCCCATTTGACCTGGAAAAGATCAAGCAGCAAATTTGCTCGGAAATAGCCGAAGGGCAGCTGGAAAAGTACTCTTCAGTGGTGAATTTCCATGGCTACGAGCTGTGCCTGAGCGATTCTGACGATGAGCCTGCCGGTGGAGAGCCACCGTACCATTGTGACCTGTGCAATCTGTCGTACACTCGCAAATATCGACTGATGCGGCACACCCTGGAGGAGCACACCCAATCGCCTATTTCCCAGCGCTGCAACCTCTGCAAAGTGGGTTTTGTGTGTGCAAAGCTCTTCGAACAGCACCAGCGAACCCAGTGCCAGAGCAAAGGGAAGCGCTATCGTTGCCGTAAGTGTCCGGGGAAGTTCATGTGGCTGGAGAATCTGGAGAGACATGCCTGCTCCCATCGCAAGGAGGAGCAGTCATACAGGCAAATCCTCTGTTGCCTGTGCGATGCCCAGCTTCCCAGCTTAAGGCAGCTGCGCGCTCACCTGGCTACCCATCGACATGGATTGAGTGGTATTGATCCTGAGCAGAAATCTGCCTTCTTCCGTTCTTACTATCCCAACGGATTGGGCTGCAGCCTCTCAGAGCTGAGCTCCCGCATAGCTGGGGATTATGAGGACCAAGACTTTGGACGCTACTACAACGCCTGCACGGGAAGTGGCCAAGAGCTGGATCTCTTTGACTCTGACACGGAGGAGACCGATGAAGCAGACAAAACAGAGGAAAAGCCAAAACCCTCGCACACCTGCCTGCTCTGTGGAGAGACAACTATTCGTCTGCTCAAGCTGCTGCAACATCAAAGAATACTCCACTCCGAAGAGGGCACCACGTACCCCTGCTCTTGCCAGGATTGTGGCGCTGGCTTCGTCTCAGAGCCCTTGCTTCAGCAACATCGAAGACGTTCCTGTGCCAAAAAGCACTCGAAATACCAATGCCAGCGATGCAATCTTCATTTTGTGTGGCAATCGAACCACGAGCAACATCTGCGCTTGTACCACGACAAGGATGGGGATCAGGAGCAGTCGGAGGACTTCCAGCAGGGTGGAAAACATAAATCTTCGGCCGCCAAGCTTCAGTGCGATGAATGTGAAAAGGTCTTCATTTGGCACAAGGATCTCACCCGTCACAAGCGAATGCATCGCCCGCCGTCGGCAGCCCAATACGAGTGTGCCTATTGCGACCGGAAGTTCCACCGCAAAGATGGCCTCAAGTCCCACCTGCGGGTACACAacgagcagcaggagaggtTGAATGAGGAGCCGTCTTGCGCCCAATCGACCTCTACGAACAGTATTCAGAGAATGCCCGGGGAGCAGCTGACCCAACTATGCCGTCCAAATGGTTGCAAGCAAATCCAGTGCATGATTTGCCTATCGCGTCACTCGAAGATCGCCGATTTGAGGAATCACCTAAGCACACACCAATATGGTGTGTGCTTTCCACAGGAGAGAGATATTCCCAGTGCCTCGCGCTCGTTGTATCCGGAACTGGGCACTGTTTTGGATAAACAGGAGCTGGAGGGGAGGATCATGAGCGATGTGGCCGGCGGCTTGGAGTTGGAGCGATTCATTTCCATAACCAACGAGGCTGGCATTGAGCTCTCTCTTGAGAGCAGTGAAACGGAAACGGATTCAGAGCAGGACGAGGATGACGAGAGTTCCGAGGAAGCTGACCAGCAGCGGTACGCCTGCAACATCTGCCAGGTGGAGGTGAGGCGAAAGCATCAATTGTATGCCCATCAGTTAGAGCATCACCAGTGGGAGGAGGCTTCGCTTGTGTGTGCCCACTGTCAGGCGAGATTCGTGAGTGTAACGCTGCTGGAGCATCACTACAGAACCCTCTGCCGGAACCCACAGAAGCGTTTCCAGTGCCGAAAGTGTCCGCTACGCTTCCGCTGGCGGGAGAACCTGAAGCTGCACGCAAGTGCCTCCCATCAGCAAATTGGACAGCCCCAAGCTGCAGAGGAACAGAGGAGCGGCATCCAGACTGAGTTCGACCTGCAGTGTGGAGAGTGCAATCGCAGCTTCAAGATGCAGAAGGATCTCACGCGGCATACGCTGATGCATGCCCAGGAATCGAGCATATATCGTTGTCGTTGGTGTGCCCGCCGCTTCTACAGGAAGGCCAATCTCCTGCAGCACATTGAGCGGCATGGCATCGGAGCTAGCCAGTTGCCCTACGCGGAAGCTCTCCTCAATGCCTATGGTCAACCCAATGGCCAGAAGAGCGTGGAGTGCAAGGTGTGCAGCTTGAGCTTTCCCAGTATTGCTGCACTTCGCGTCCATCTGGAGACCACGGCGACGGGCAGTCACCACGAACTATCGTCCCTACAGAACTACTCGATAACCAACCAAATGGGATTCGAGCTGCACTTGGACGACTCGGAGACGGATGAGGAGGAGTCCAAGCCACCGGGCACGCCTGCTGTCTACACCTGCGGCATGTGCCAGCTCCGGTGTGTGCGAAAGTACGAGctgcatcagcaccagcaggcCATGCACAGGCTGGAGAAGATCCCCGATGGCTGCGATCTGTGCATTTTCAAGAGTGTCTCTCCCGATCTTATCGCGCATCACAAGCGAGTGCAGTGCCACAACCGAGAGAAGCAGTTCACCTGTGCCAAATGCGGCTACAAGTTCATGTGGGAGTCCAATCTCCTGCTGCACATGCAGCTGCAACATGGCAAGGCCGAAGAACAGGATGATCCACCCCTGGACGAGCCCGTGGAGCAGAAGGCTGTGTGCCCAGTTTTTCAGTGCGGCCTCTGCCCAAGGAAATACAATCGCAAGGATCGGCTGACGGCCCATGTGAAGAAGTTCCACAACCCAGTGGTAGGGAGCGCTCCGAACACCATAAGGACTGCTCCCATCCGGCCAACTTCGCCCAAGGAGCCGAAACGCTTCCTATGCGCCTTCTGTGGCAAGGCTGTAAGCTCCTCCTCGAACCTCATCATCCACATGCGTCGGCACACGGGCGAGAAGCCTTTCAAGTGCGACTACTGCGAAATGGCCTTTCCGCGCTCCTCCGATCTCCAGTGCCATCGACGAACGCACACCGGGGAACGGCCCCACATCTGCACCGTCTGCCAGAAGGGCTTCGCCAGATCCTAcaaactgcagcagcacatGCGCATCCACAACGGCGAGCGGCCCTACAAGTGCACCTACTGCGAAAAGAGCTTCACCCAGTCCAACGACCTGACACTCCACATCCGCCGCCACACGGGCGAGCGTCCCTATCAGTGCGGGGTCTGTGGCGAGCGTTTCATCCAGGGTACGGCCCTGAAGAATCATCGCCTACAGCAGGGCCACTATGACGAGGCCAGCCAAGGCGCGGCAGAGTCCGCAAGACGCACGGTCCTAGAGCAATTTACAGTTGAATAA
Protein Sequence
MLPSNICRTCAQQNTNLLPLSTSLDKYTNKSFYDVLQELTQIDPLLENADDNLPQHLCTDCLGRLENAYAFVEQARKVNGELLVRLRECLEESPIDIPQQQIKTEIDIDEEQRDFTDSGEAQRSSDVDVESAGVCSVELKWTPESASEEENAADALLNDEDDDAQPYILRRSPRKVKQQADSEEEDGVSPSPNKRRRGRPPGLAKSQSRNSEGRHACEVCGKTFSWFRDMKRHARVHYEKASFVCDTCGKGFLRKDKYTFHLRSHEKREAKYQALQLKNEWRFAERLYSSGRLKRMQCKLCGLKCQRMQELRSHLESHVHTDSLFSLRADNDVVKEHFATGPFDLEKIKQQICSEIAEGQLEKYSSVVNFHGYELCLSDSDDEPAGGEPPYHCDLCNLSYTRKYRLMRHTLEEHTQSPISQRCNLCKVGFVCAKLFEQHQRTQCQSKGKRYRCRKCPGKFMWLENLERHACSHRKEEQSYRQILCCLCDAQLPSLRQLRAHLATHRHGLSGIDPEQKSAFFRSYYPNGLGCSLSELSSRIAGDYEDQDFGRYYNACTGSGQELDLFDSDTEETDEADKTEEKPKPSHTCLLCGETTIRLLKLLQHQRILHSEEGTTYPCSCQDCGAGFVSEPLLQQHRRRSCAKKHSKYQCQRCNLHFVWQSNHEQHLRLYHDKDGDQEQSEDFQQGGKHKSSAAKLQCDECEKVFIWHKDLTRHKRMHRPPSAAQYECAYCDRKFHRKDGLKSHLRVHNEQQERLNEEPSCAQSTSTNSIQRMPGEQLTQLCRPNGCKQIQCMICLSRHSKIADLRNHLSTHQYGVCFPQERDIPSASRSLYPELGTVLDKQELEGRIMSDVAGGLELERFISITNEAGIELSLESSETETDSEQDEDDESSEEADQQRYACNICQVEVRRKHQLYAHQLEHHQWEEASLVCAHCQARFVSVTLLEHHYRTLCRNPQKRFQCRKCPLRFRWRENLKLHASASHQQIGQPQAAEEQRSGIQTEFDLQCGECNRSFKMQKDLTRHTLMHAQESSIYRCRWCARRFYRKANLLQHIERHGIGASQLPYAEALLNAYGQPNGQKSVECKVCSLSFPSIAALRVHLETTATGSHHELSSLQNYSITNQMGFELHLDDSETDEEESKPPGTPAVYTCGMCQLRCVRKYELHQHQQAMHRLEKIPDGCDLCIFKSVSPDLIAHHKRVQCHNREKQFTCAKCGYKFMWESNLLLHMQLQHGKAEEQDDPPLDEPVEQKAVCPVFQCGLCPRKYNRKDRLTAHVKKFHNPVVGSAPNTIRTAPIRPTSPKEPKRFLCAFCGKAVSSSSNLIIHMRRHTGEKPFKCDYCEMAFPRSSDLQCHRRTHTGERPHICTVCQKGFARSYKLQQHMRIHNGERPYKCTYCEKSFTQSNDLTLHIRRHTGERPYQCGVCGERFIQGTALKNHRLQQGHYDEASQGAAESARRTVLEQFTVE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00580900;
90% Identity
iTF_00580900;
80% Identity
-