Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 6.6e-38 6.7e-35 119.2 0.0 1 85 69 152 69 154 0.97

2 3 0.2 2e+02 2.3 2.1 29 87 212 272 191 273 0.79

3 3 6 6e+03 -2.4 0.2 72 82 284 294 274 308 0.48

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	6.6e-38	6.7e-35	119.2	0.0	1	85	69	152	69	154	0.97
2	3	0.2	2e+02	2.3	2.1	29	87	212	272	191	273	0.79
3	3	6	6e+03	-2.4	0.2	72	82	284	294	274	308	0.48

Coding Sequence: ATGGATACGACCACCACAAGCCCGCAAGTGTTTCAGTCCAGCTTCTCCATCCGGTCACTGCTCTCCGAGAAGGGCGAGGGCGAGTACTACCTCCAGCCGTCCAGTCCCAGTCATTCGTGCAACAGCTCCGAGGATGCCTCCTCCGATGAGAGCcgcggcagcaacggcagcagcggcagtgtcACAACCAGCCCCAAGGACGCCAGCAAGCCCGCCTTCACCTACAGCGCCCTCATCGTGATGGCCATCCGCAGCAGCCCCGAGAAGCGACTGACCCTCAGCGGGATCTGCAAGTGGATAGCCGACAGCTTTGCGTACTACCAGAACCACAAGAGCGTCTGGCAGAACTCCATACGGCACAACCTCAGCCTGAATCCGTGCTTTGTGCGCGTGCCGCGCGCCCTAGACGATCCCGGACGGGGCCACTACTGGGCCCTGGATCCGTATGCCGAGGACCTGACCATTGGCGAGACAACGGGTCGCCTGCGGCGCAGCCAGCATCTGCTGGGACGCTCGAAGGCGGCTCATCCctaccagcagcagatgcagctCTATGCCCATTCGATGTTCAAGCCGCATGCTGCCTACTTTCCCATTGCCGACACGGCacggcagcatcagcagcagcagcatcatacGATCTTGATGCAGAACTACCATCAGGCAGCggcactggcacaggcacaggcacagcaacagcatcgaCAGCAGACGACGCTATCATCGCACttccatcagcagcagcagcagcagcatcatcatcgacCTGGTAACAGCAATTACTACCAGcgacaacaccagcaacagcaacagctacaacaacaacagcagcaacagcggcagcaacagcaacagcaacacaattattacttgcaacagcaacatcatcagttgcagcagcagcaggagcaataTCCAAGTCCGTATGCCGACAAGTGGATGCGACAACCCATAGAATGCTTGTGGCGTTAG
Protein Sequence: MDTTTTSPQVFQSSFSIRSLLSEKGEGEYYLQPSSPSHSCNSSEDASSDESRGSNGSSGSVTTSPKDASKPAFTYSALIVMAIRSSPEKRLTLSGICKWIADSFAYYQNHKSVWQNSIRHNLSLNPCFVRVPRALDDPGRGHYWALDPYAEDLTIGETTGRLRRSQHLLGRSKAAHPYQQQMQLYAHSMFKPHAAYFPIADTARQHQQQQHHTILMQNYHQAAALAQAQAQQQHRQQTTLSSHFHQQQQQQHHHRPGNSNYYQRQHQQQQQLQQQQQQQRQQQQQQHNYYLQQQHHQLQQQQEQYPSPYADKWMRQPIECLWR

Sequence clustering based on sequence similarity using MMseqs2