Basic Information

Insect: Drosophila affinis
Gene Symbol: RREB1
Assembly: GCA_037356375.1
Location: CM074802.1:8645630-8651636[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 12 0.037 3.1 8.8 0.8 1 21 238 258 238 260 0.93

2 12 0.00026 0.022 15.5 0.2 1 23 270 292 270 292 0.98

3 12 8.4e-05 0.007 17.1 7.3 1 23 298 320 298 320 0.98

4 12 0.66 55 4.8 3.8 2 19 562 579 562 581 0.97

5 12 0.038 3.1 8.7 0.1 1 23 726 748 726 748 0.97

6 12 1.3e-05 0.0011 19.7 0.7 1 23 758 780 758 780 0.99

7 12 0.00086 0.072 13.9 2.0 1 23 786 809 786 809 0.97

8 12 0.0031 0.26 12.2 2.0 1 23 1090 1113 1090 1113 0.95

9 12 9e-05 0.0074 17.0 0.3 2 23 1507 1528 1506 1528 0.97

10 12 0.15 13 6.8 6.3 1 23 1534 1557 1534 1557 0.97

11 12 0.012 1 10.2 0.6 3 23 1758 1778 1756 1778 0.95

12 12 0.0014 0.12 13.2 4.8 1 23 1784 1806 1784 1806 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	12	0.037	3.1	8.8	0.8	1	21	238	258	238	260	0.93
2	12	0.00026	0.022	15.5	0.2	1	23	270	292	270	292	0.98
3	12	8.4e-05	0.007	17.1	7.3	1	23	298	320	298	320	0.98
4	12	0.66	55	4.8	3.8	2	19	562	579	562	581	0.97
5	12	0.038	3.1	8.7	0.1	1	23	726	748	726	748	0.97
6	12	1.3e-05	0.0011	19.7	0.7	1	23	758	780	758	780	0.99
7	12	0.00086	0.072	13.9	2.0	1	23	786	809	786	809	0.97
8	12	0.0031	0.26	12.2	2.0	1	23	1090	1113	1090	1113	0.95
9	12	9e-05	0.0074	17.0	0.3	2	23	1507	1528	1506	1528	0.97
10	12	0.15	13	6.8	6.3	1	23	1534	1557	1534	1557	0.97
11	12	0.012	1	10.2	0.6	3	23	1758	1778	1756	1778	0.95
12	12	0.0014	0.12	13.2	4.8	1	23	1784	1806	1784	1806	0.99

Sequence Information

Coding Sequence: ATGCTAGcagcacagcaacagcagcagcagcagccaccccAGCCACACAGCAgtgccaccgccgcctccgTCACACAGGCTGCGATGGAGCGCCAGCGACGCGAGTCCACCACATCGGAGTCCTCGCTGGAGCATCTCGACCTTGGCCGCACACCAAAGAagcttagcagcagcagcggcccaCAGCCCACGTCGACGCCGCACGACACGGCCCCAGCGTCCGCGGTGGTGTCAGCGTCGCGCAAGCGGAAGCTGcgacagcaccagcaccaacagcagcagcagcaggatctgctcagcgacgacgaggaggaggaggagctgcgtCCGCTGGAGGAGACGATGGCAGTGCAACGGCCGCGCCACAAGCAGCGACGCAACGGCCCCGCCTCCGCGGCGGCGGCCAGCGCTAGCATCGTGATGGACTACAGTGCCGGCGATGCCAGTTCGCTGCGCAAGAAGTTCCGGCTGAACCGCAGCGGGGCCAATGGAGATCTCTCGGAGTCCGGATTCGTCGATGCCAGCAGCTACAACAACAGCCATGCCGCAGCGGCCGCCGTCTCTGCTGCAGCGCAGCAGGCGTCGAAtgcctccagcagcagcagtagcagcagtggcagcggcagcggcagctcggGCGCCTCCTCGCCGGAGGGCCTGTGCCTGTCCAGCGGCGAGTCCGGCATCGGGGCTGGCGACGAGCACATGAAGTACCTTTGCCCCATCTGCGAGGTGGTCTCGGCCACGCCCCACGAGTTCACCAACCACATCAGGTGCCACAACTACGCCAACGGCGACACCGAGAACTACACCTGCCGCATCTGCTCCAAGGTGCTCTCCTCGGCCTCATCGCTAGACAGACACGTGCTGGTGCACACGGGCGAGCGTCCGTTCAACTGCCGCTACTGCCACCTGACCTTCACCACCAACGGCAACATGCACCGCCACATGCGCACCCACAAGCAGCACCAGTCGACGACGTCGGCAGCGCAGCAATCGGCTTCGCAGAGCgccagcggcggcggcggctctctgtcgcagtcgcagcagcagcgacgccactcacagcagcagcagcagcagcagcaacaccagcagcagtcgctgtcgcagcagcagcaccagggtGGTGCAGCAGGTCATCCGGGACGTGCGGAGAGCTATGAGAGCGATGCCAGCTGTTCCACGGATGTATCCAGTGCCCACAGCCACACCCATAGCCATGGGAGTAGTCACGCCCGCTCCcgcgcccacgcccacacccacaccaacaacaacaacaatcccCATAAAGCGAACAACAACCACAaggagatgcagcagcagcagatccagGAGCGGATCAAGCAGCGTCGCCCCAAGACcaccatcaacaacaacatcatcgACGATGGCTCCCACGCGGAGGAGGACGAAGAGGAGCGTGACGAtcgggagggggaggaggagcatcACGATCCGGACACCGAAGATGATGTGGCCATGCCCCTATCCATTACGAGCACCCCGGATGTGGCCACCCTGCTGGCCGGAGTCAATGCATCCTCGCGGGCTGAATCGCGCTCCCGCTCACCCTCGCCGGCCATGCCCCTGCTGAGCTGCCCTGCTTGTGGCGCCTCCGACTTTGATTCGCTGCCAGGGCTGTGCGCCCACCTGGACGCCCGGCACTCGGACATACCCGCCAAGTGCCGCGACTGTGACGTGATCTTCGCCAGCCACCGCCAGCTGCAGGCGCACTGCTGCCGCGGCCTGGTGGGGGTGGATCTGCCGCCGCTCCTGGGGGCCAGCAGCTCACCGCTGCACCAGGGTGAGGATGAGGACGACGAGGATGCCGAGGACGAGGCCAGGACCGAGAGGGAGGCCGAACAGCACGGAGACTTCTTCCAGCAGCTGTACCTCAAGAGCAaggcagccgctgccgctgtcgccgGGGCATCCACCTCCTCGCCGCCGTCCCCCATCAAGCACGAGCCGGCGGACAGCAAGGATCTGGCTGACATCCAGAGCATCCTCAACAtgaccagctccagctgcaccTCCAGCTTCCTGCGCAACTTCGAGCAGTCGGTGAACACGCCCTGCTCCAGCCAGTACAGCCTCGACGGGCGcgaccaggaggaggaggcccaaGATGTCTTCACCTCGGAGTTCCGCCGCATGAAGCTGCGCGGCGAGTTCCCCTGCAAgctctgtgtggcagtgtTCCCCAATCTGCGCGCCCTCAAGGGCCACAACCGGGTGCATCTCGGCTCCGTTGGCCCCTCCGGCCCGTTCCGTTGCAACATGTGTCCGTATGCCGTCTGCGACAAGGCCGCCCTCGTCCGTCACATGCGCACCCACAACGGGGACCGACCGTACGAGTGCGCCGTCTGCAACTACGCCTTCACCACGAAGGCCAACTGCGAGCGGCATCTGCGCAACCGGCACGGCAAGACCAGTCGCGAGGACGTGAAGCGGGCCATCGTCTACCATCCGGCGGAGGACGCCAGCTGCGAGGACAGCAAGTCGCGCCTGGGACTCGGCGATGATCTGGCCGATCTGAGCTTCCGCTCGGTGTCGCCGcccccaccgccgccgccggccCCAACCAGCGCTCCGATTACCGAGGGCTCACAACTGAAGCACATGCTCCTGGGAGAGCCGTCGCCACCATTGCATACTCCCACAGTGGCCgcggctgctgccgttgccggaCCACCATCCAAGATCCAAGTGAAGAGCCTCGACCAGTTGGTGGACAAGAAACAGCCTGCCGCTGGCCCTGCCCTCGACTTTAGCATGGATGTGCTGGATCTCAGCAAGAAGCCCAACACTGGAGGATCAGCCTCGGcttctgcctccgcctctgcctcgtCGGCCCCCTCAACGGTGCCAGAACTGGCTGCCGttctggagcagcagcagcagcaacaacagcagcagcaacaacagctgctcctggcccagcagcagctctttgGTGGTGGAGCCGGAGCAGCGGGAGCAGCAGGCGATGCCGCCTCTCAGTACATGCAGCAGCTGTTCCGCAACCTGATGTTCCAAACACAGACGCCGGGCTTTCCCTTCTTTGGATTCATGGCCCCGCCTCCACCACAGGGTAGTGCCGAGAAGCCGCCGCAGCTGAGTCCGCCATCGCGGATGGgggccctgcccctgcctatGCCAGTGGGCGTGCCCGTTCCGTCTGGCGGCCCCGTCAAGATGGTCATCAAGAACGGAGTGCTGATGCCCAAACAGAAGCAGCGCCGCTACCGCACCGAACGGCCCTTCGCCTGCGAGCACTGCTCGGCCCGCTTCACCCTGCGCTCCAATATGGAGCGTCACgtgaagcagcagcatccccaGTTCTATGCCCAGCGCCAGCGGAGCGGACACCACGTGATGCGCGGACGCGGTGCCTCCAACGCCGCAGCGGCTGTGGCCGCAGCCGCggccgcagcggcagccatGAGCCAAGGCGGATCCGGGGCGGGCCATGTGCACGGCCATGGCCCCATCTCGGAGAGGGTGAAGTACGCCATCCTGGCGCAACAGCTGAAGTCGCACAAGAACACGGATCTGCTGCAGCAGGCTCTGGCCCACGGATCCAGCAGCGTGGCCGGTGGCAACCAACTCCTCCACTTTGGCTACGGCTCACCCCAGACGCAGTCGCACTCCCAGTCACAGTCCCACAaccacatcccatcccactcccagtcccagtcgagTCCCCATGGCCATGCTCAATCCAGTTCTGGCTCCCATCTGCCTTATCTGGTGAATGGGATCCACAATGGGAGCAATGGGAACAACGGCCAGGCGAGTGCCATCGATGACGACGAGCCCAAGCTAATCATtgacgaggatgaggatggcGAGGGTGATGTGGAGGAGTTCGACGAggacgatgaggaggaggaggatgagcccgaggacgaggacccggagccagagccaatgGAAGAGCCGGAACAGGTGCACAACGACGAGCCAGAGGACGAGGATCAGGAGCTGCCCAAGCCCCTAGAGCACATCTCACAGCCCAGTGCTGCAGCTGCCAATGAGGCGGCCAAGAAGATGGCCGAGACAATTCTCGAGCAGGCCATCAAGGCGGGCAAGGCCACGCCCACTGCCACGCCCATGAGCACGCGTACGCCGTCACCCAGTCCGGATCAGACGAACAACGCCATGCCGGAGCCGAGTCCCCCGAATCCCACCATGAAGTCGATGATCGCCCAGGCCGAGTCCGTGGCCAAGTCTCTGAAGGAGGTCGCCAGCTCTCCGTTCAAGGACGAGTCGCAGGACCTGGTGCCGGTGGCCAAGCTGGTGGACAACGCCACCAGCAGCCAGATGAGCTTCAATAGCTACTTCCGGCCCAGCGACGTGGCCAACCACATGGAGCAGAGCGATGAGGAGGGTCTCGTGGCCTCCGGCAGCGCCAGCGAGAGCAACAATTCGGGAACGGAGGACgtcaccagcagcagttccgGCAGCGAACCGAAGAAGAAGTCCGCCTACAGCCTGGCCCCCAATCGCGTCTCATGCCCCTACTGCCAGCGCATGTTCCCCTGGAGCAGCTCGCTGCGACGCCACATCCTCACCCACACCGGCCAGAAGCCCTTCAAGTGCTCCCACTGCCCACTGCTCTTCACCACCAAGAGCAACTGTGACCGCCATCTGCTGCGCAAGCACGGCAACGTCGAGTCCGCCATGTCCGTCTACGTGCCCACCGAGGACGTCAGCGAGCCGATACCCGTGCCCAAGTCCGTGGAGGAGATCGAGCTCGAGGAGCAGCGTCGTCGCCAGGAAGCGGAGAGGGAGCGCGAACGTGAGCGGGAgttggaactggaactggaacggGAGCGCGAGAAGGAGCTGGAGCGCGAACGAGAACTGGAGCGGGAGCGAGAGCGCGAGAAGGAGCGTCTGGTGCTCATCCAGAAGCTGGCGGCTCAGATGAATgccgctgcagccgccgctgctgctgcctcggcCACCGATGCCGGCGCTGGCGGAGATCTGCCGTACAAGTGCCACCTGTGCGAGGGCTCCTTTGCCGAGCGTCTGCACTGCCTCGAGCACATCAAGCAGACGCATGCCCACGAGTTtgccctgctgctggccaagggAGCCATCGAGCCGGAGTCCCGTGCCGGGGAGTCCAACCACCAGCAGCtcccccaacagcagcagagcaccCCGGGCGCCGGTTCCGACGATGAAGCgagtggcggtggcggtgcaCGCGGAGCCTCTGGCAAGTATCCAGACTACAGCAACCGCAAGGTGATCTGCGCCTTCTGTCTGCGCCGCTTCTGGTCCACCGAGGACCTGCGCCGGCACATGCGCACCCATTCCGGGGAGCGGCCGTTCCAGTGCGAGATCTGCCTCCGAAAGTTCACCCTCAAGCACAGCATGCTGCGTCACATGAAGAAGCACAGCGGACGCGCCCACAACGGCGACAATCCCGGCTCCGACTGTTCCGACGATGAACAGGTCGCCACTCCGCCATCCACCCCAGGACCCACTCCGGCCACCcccaccaccaacaacaacaacagttgccagaacaacaacaacaacaacaacagcagcaacaccaacgcCAATGCAAAGGTGGGCCTGCGTCTGCCGAAGCTGCACGAGCTGCTGGACAAGTCGAGCGAGTGGCGGGCCAGCCGGCTGGGCGAGCACAAGGAGAACATCGGCGAGGCGGCAACAccgtcagcagcagcggtggccaGCTCCGACCTGATCGGCAATCTCCTGGGCATCAGCGACCAGGGCATACTCAACAAGCTGCTCTCATCCGCCGACGAGGCGGCCAAGTTCCTGGGCGTGGACAACAAGTAG
Protein Sequence: MLAAQQQQQQQPPQPHSSATAASVTQAAMERQRRESTTSESSLEHLDLGRTPKKLSSSSGPQPTSTPHDTAPASAVVSASRKRKLRQHQHQQQQQQDLLSDDEEEEELRPLEETMAVQRPRHKQRRNGPASAAAASASIVMDYSAGDASSLRKKFRLNRSGANGDLSESGFVDASSYNNSHAAAAAVSAAAQQASNASSSSSSSSGSGSGSSGASSPEGLCLSSGESGIGAGDEHMKYLCPICEVVSATPHEFTNHIRCHNYANGDTENYTCRICSKVLSSASSLDRHVLVHTGERPFNCRYCHLTFTTNGNMHRHMRTHKQHQSTTSAAQQSASQSASGGGGSLSQSQQQRRHSQQQQQQQQHQQQSLSQQQHQGGAAGHPGRAESYESDASCSTDVSSAHSHTHSHGSSHARSRAHAHTHTNNNNNPHKANNNHKEMQQQQIQERIKQRRPKTTINNNIIDDGSHAEEDEEERDDREGEEEHHDPDTEDDVAMPLSITSTPDVATLLAGVNASSRAESRSRSPSPAMPLLSCPACGASDFDSLPGLCAHLDARHSDIPAKCRDCDVIFASHRQLQAHCCRGLVGVDLPPLLGASSSPLHQGEDEDDEDAEDEARTEREAEQHGDFFQQLYLKSKAAAAAVAGASTSSPPSPIKHEPADSKDLADIQSILNMTSSSCTSSFLRNFEQSVNTPCSSQYSLDGRDQEEEAQDVFTSEFRRMKLRGEFPCKLCVAVFPNLRALKGHNRVHLGSVGPSGPFRCNMCPYAVCDKAALVRHMRTHNGDRPYECAVCNYAFTTKANCERHLRNRHGKTSREDVKRAIVYHPAEDASCEDSKSRLGLGDDLADLSFRSVSPPPPPPPAPTSAPITEGSQLKHMLLGEPSPPLHTPTVAAAAAVAGPPSKIQVKSLDQLVDKKQPAAGPALDFSMDVLDLSKKPNTGGSASASASASASSAPSTVPELAAVLEQQQQQQQQQQQQLLLAQQQLFGGGAGAAGAAGDAASQYMQQLFRNLMFQTQTPGFPFFGFMAPPPPQGSAEKPPQLSPPSRMGALPLPMPVGVPVPSGGPVKMVIKNGVLMPKQKQRRYRTERPFACEHCSARFTLRSNMERHVKQQHPQFYAQRQRSGHHVMRGRGASNAAAAVAAAAAAAAAMSQGGSGAGHVHGHGPISERVKYAILAQQLKSHKNTDLLQQALAHGSSSVAGGNQLLHFGYGSPQTQSHSQSQSHNHIPSHSQSQSSPHGHAQSSSGSHLPYLVNGIHNGSNGNNGQASAIDDDEPKLIIDEDEDGEGDVEEFDEDDEEEEDEPEDEDPEPEPMEEPEQVHNDEPEDEDQELPKPLEHISQPSAAAANEAAKKMAETILEQAIKAGKATPTATPMSTRTPSPSPDQTNNAMPEPSPPNPTMKSMIAQAESVAKSLKEVASSPFKDESQDLVPVAKLVDNATSSQMSFNSYFRPSDVANHMEQSDEEGLVASGSASESNNSGTEDVTSSSSGSEPKKKSAYSLAPNRVSCPYCQRMFPWSSSLRRHILTHTGQKPFKCSHCPLLFTTKSNCDRHLLRKHGNVESAMSVYVPTEDVSEPIPVPKSVEEIELEEQRRRQEAERERERERELELELEREREKELERERELEREREREKERLVLIQKLAAQMNAAAAAAAAASATDAGAGGDLPYKCHLCEGSFAERLHCLEHIKQTHAHEFALLLAKGAIEPESRAGESNHQQLPQQQQSTPGAGSDDEASGGGGARGASGKYPDYSNRKVICAFCLRRFWSTEDLRRHMRTHSGERPFQCEICLRKFTLKHSMLRHMKKHSGRAHNGDNPGSDCSDDEQVATPPSTPGPTPATPTTNNNNSCQNNNNNNNSSNTNANAKVGLRLPKLHELLDKSSEWRASRLGEHKENIGEAATPSAAAVASSDLIGNLLGISDQGILNKLLSSADEAAKFLGVDNK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00474019;
90% Identity: iTF_00474019;
80% Identity: -