Basic Information

Insect: Drosophila affinis
Gene Symbol: L
Assembly: GCA_037356375.1
Location: CM074799.1:17117608-17124298[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 18 1.3e-05 0.0011 19.6 3.1 1 23 157 179 157 179 0.98

2 18 0.37 31 5.6 6.2 1 23 185 207 185 207 0.97

3 18 1.8e-07 1.5e-05 25.5 3.2 1 23 213 235 213 235 0.99

4 18 1.3e-05 0.0011 19.6 0.4 1 23 241 263 241 263 0.99

5 18 0.024 2 9.4 0.2 2 23 339 363 338 363 0.92

6 18 0.004 0.34 11.8 0.2 2 23 393 415 392 415 0.95

7 18 0.065 5.4 8.0 0.7 1 23 497 519 497 519 0.97

8 18 0.0055 0.46 11.4 0.1 2 23 527 548 526 548 0.91

9 18 0.00029 0.024 15.4 0.2 1 23 556 580 556 580 0.95

10 18 1 87 4.2 0.3 2 20 586 604 585 605 0.93

11 18 1.4 1.1e+02 3.8 0.9 2 23 616 638 615 638 0.95

12 18 0.0027 0.22 12.3 1.1 1 23 683 706 683 706 0.97

13 18 0.0053 0.44 11.4 1.2 2 23 888 910 887 910 0.96

14 18 0.12 10 7.1 0.1 1 23 916 938 916 938 0.92

15 18 2.7 2.2e+02 2.9 0.6 2 23 946 967 946 967 0.95

16 18 0.78 65 4.6 0.5 2 23 1067 1088 1067 1088 0.94

17 18 0.075 6.2 7.8 0.0 1 23 1098 1120 1098 1120 0.96

18 18 0.00023 0.019 15.7 1.2 1 23 1127 1149 1127 1149 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	18	1.3e-05	0.0011	19.6	3.1	1	23	157	179	157	179	0.98
2	18	0.37	31	5.6	6.2	1	23	185	207	185	207	0.97
3	18	1.8e-07	1.5e-05	25.5	3.2	1	23	213	235	213	235	0.99
4	18	1.3e-05	0.0011	19.6	0.4	1	23	241	263	241	263	0.99
5	18	0.024	2	9.4	0.2	2	23	339	363	338	363	0.92
6	18	0.004	0.34	11.8	0.2	2	23	393	415	392	415	0.95
7	18	0.065	5.4	8.0	0.7	1	23	497	519	497	519	0.97
8	18	0.0055	0.46	11.4	0.1	2	23	527	548	526	548	0.91
9	18	0.00029	0.024	15.4	0.2	1	23	556	580	556	580	0.95
10	18	1	87	4.2	0.3	2	20	586	604	585	605	0.93
11	18	1.4	1.1e+02	3.8	0.9	2	23	616	638	615	638	0.95
12	18	0.0027	0.22	12.3	1.1	1	23	683	706	683	706	0.97
13	18	0.0053	0.44	11.4	1.2	2	23	888	910	887	910	0.96
14	18	0.12	10	7.1	0.1	1	23	916	938	916	938	0.92
15	18	2.7	2.2e+02	2.9	0.6	2	23	946	967	946	967	0.95
16	18	0.78	65	4.6	0.5	2	23	1067	1088	1067	1088	0.94
17	18	0.075	6.2	7.8	0.0	1	23	1098	1120	1098	1120	0.96
18	18	0.00023	0.019	15.7	1.2	1	23	1127	1149	1127	1149	0.97

Sequence Information

Coding Sequence: ATGATGGCCCTAAAAATGCTTTATCGCGGTCCCAGTTCGCGTTTGGAGAATCTAATTGAGAAGATCCAGGCTACCAAGGAGATCACAAATAACGACATGTACAGTACCCACACCTCGTCCAGCTACTCGCCGAGCATCTCCGATGGGACCATGACACCCAATTCGCATCATCTGGCCGCTACCTCGGCGAACGCCGGCCAGGAGGATCTCCATCTGACGGCTGATGGCAAGTCGAACGGAGTCCCTGGAGAGGAGCCAGCCAAGCCGAAGCGACAGCCGCTcttccaccaccaccaccatcactaCCATCACCAGCAGGCCCTGAAGATTGCCAACAAGTTGCGCAAAATCAATAAGGAGGCCAAGATGgcagctgcaggagcagcaggagccggaACTGGCGCTGGAGCAGCCGCAAAGTTTGATAAGTTGACAGGCGAAGGCATTAAGAGTCGCGGCGACGGCTCCTATCAGTGCCAGTTCTGTGATAAGACATTTCCGCGTCTCGGCTACTTGAAGCATCACGTGCAGAGCCATGCCGAGCATCTGCCCTTCAAGTGCGAGTACTGCGCCAAGCTGTTCAAGCACAAGCGCTCCCGGGATCGCCATAAGAAGCTGCACACCAACGAGCGGAACTACAAGTGTCCGCACTGCGAGGCGGCCTTCTCCAGGAGCGATCACCTGAAGATCCACATGAAGACGCATGACATCCAGAAGCCCTTCCAGTGCAGCATGTGCAACAGGGGCTACAACACGGCCGCGGCTCTCACCTCACACATGCAGAAGCACAAGAAGAACGCCGCAATCCTGGCTGCCGGCGGCAATCCCAATGCCCTCAACTACAGTCCCCGATCCACTGGCTCCGCCTCGGCCTCGGTGTCCAGCAATGGAAGCCTGCACAAGCGGCGCTacgccctggccctggccaccGACAGCAGTCCCAGTCGCCTGGACTTCCCCAAGAGATCGCGCAGCAGTCATGTGGCCAGCACGCCCACGCCAACGCCTCTGCTGAGATGCAGCTACTGCCCCAAGGCGACAGAGTTCAGCAGCCTGGAGCAGCTGAATGCCCATCTCCAGAATGTCCACGAGCAGacgcagcagccccagcagcagccccagctgcagcagcagtcggcGAAGACTCCCGTCCAGGAGGGAGAGGGTTTCCAGCTGAGCTGCGAGTACTGCACCATGAAGTTTGGCAACATTGCCGGACTCTTCCAGCACATGCGCGCGACCCATCTTGATCGTCTGAGCAGCCCCAACTCCTACTACGAGCACTTCAATCGCCTGGCCACAGCCGGAACATTCAGTCCACGGCTGGCTCTGGATCTGCCCAAGATCAAGACGGATCTGGGCAGTCCCGAACGAGAGAACCGGCCCTCCGAGGACGACCTCCCAACGGATCTGAGCAGCAACAAGCGTCGACCGCAGACACCCAATGCTCCGCCGAATCCTCCGCAAGCGAACGCCCCGCCCGGCATCTTCTTCTGCAATCAGTGCAACGCTGGACTTCCCGACTTCGAGAGCTTCCGCAACCACCTGAAGAGCCACATTGCCGAAGGAATGCAGCTGATCTGTCCCCACTGTGGGCTGAGCCTCCCGGAGCAGTCCGAGTTTGAGCGGCACGTGGTGGGACACTTCCTGATCCCCAACTCCGAGTTcaactgcagctccagctgcggCAAGAGCTTCGGCAAGGCCGAGGAGCTACAGCAGCATCTCATCACCGAGCACGTCCTCACCCTACTCAAGTGCTCCCTCTGTTCGGAGACGTGCGAGACGCGGATGGCCATGCAGCTGCACCTGGCCTGCGCCCACAGCCAAGAGACGAAGCTGCTGCGCTGCAGCGCCTGCATGGAGGTCTTCCGTTCCGATGGCGACTTTCATGTGCACGTCAAGACGCGCCATCAGCTGGGGAATCATCACCACCCGatgggcggcagcagcagtccggCCAATCCGCTGCAGTGCATGTTCTGCCGGGCCGTCTGCTCCTCTGAGCTGGAGATGCACTTCCATCTGGCAGCCCATGCGCGCCAGTTCCGCTGTCCATCCTGCCCGGAGACCTTTCACGTGGAGTTCCTGCTCGACAGGCACATGCAGAGCCAGCATGGCGGCGTCAAGGACAAAGAGCAGCCGCCACAAAGCTCCCCCAACATGGGCAGTCTCTATGTGAACGCCCTGCTGCCTCCCCTTGCCGCAgcggccgctgctgcagctgccaccaacaacaacagtagcaTCATCGACTACAACGTGGCCTTCAAAGGGTTGTTCGGCGGAGGATCGGCAGGAGGAAGTGCACCCACTGGTCCCTCGGCGGCCGGCAAGTTCTACAGCCCCCTGCAGGTGGACACGAATGCCCTGAAGGCGCAGACCTCGCCCCATCCCGCCCTGATGTACGGCCTCAGCCAGCGGTACCTGATGGAGATGTATGCCGCCAAGTCCACGTCACCGGCCAACAGTGCCGCCAACGAatcagcaggaggaggaaccTCCGCCATCAATGCCCCGCCAGCGCCACAGGCACCGCCGCCTCCCGCACCAGCTGTCACCTTCAGCTGTGGGATGTGCGAACGCCAGGATCTGCGCAGCGAGGCGGAACTCCACTCACACCGGAAACTAGCCCACAACCTGAAGACGGGCGTGAGCCTACGGTGCGCCTACTGTGCGGGCAACTTCAAATCGAGGGCGGAGCTCGAGCAACACATGAAGAGCTGCCACAACTCGACGGGCAAGCACAAGTGCCTCATCTGCGACGAGATCTTCCCCTCGCCGGCCATCCTAGCCGAGCACAAGCTGCAGCACTCCAAGGTGGGTCAGTCGGGCAAGTGCGCCCACTGCAGCCACCCATTGGAGGATGTGGCCGCCTTCCGGGCCCATCTCAGCGAGCATGGCAGCGATGGAGCCTCCCTGCCCTTGGCCTGCATCTGCTGTCGCCAGACCCTTCACTCGGAGTTCGAGCTGAGCCTCCATGCCAAGTTTCACACGAAGTCCTCGTCCAGTGGCGGCAGCCTCCAGGAACCAGTTTGCGCCCTCTGCCTGGAGCCCCTGCCAGGGGCAGTGGAGGGTCCCACCACTCCGGCCAAGCTCTGCGAAAAGTGTTGCCGCAAGCACAACCTCAACGGCAAGCGGAGCAAGGTCAGCGAAGCCCCTGTGGCCCAGGCGCAGCCGACTCCCTACATGGAGAACCGCTGCAACCTGTGCAAGATGATCCTGCCGCATGCCCAGAAGCTGCAGGAGCACCTGGTCGAGCACACCTTCGCTGGCACCGAGCAGCGCGGCTTCAATTGCTATATCTGCTCGGCCGTGTTCACGGCCCCTGGCGGTCTCCTTGGCCACATGGCCGAGCACGGAGCCCACTCGCGTCCCTACGACTGCAATCTCTGCCCCGAGAAGTTCTACTTCCGAGCCGAGCTGGAACACCACCAGCGGGCACACGAGCTGAGGCCATCGGTTCGTCCATCACTCGACAAGCCAGAGCCCCCGATGCGCGGCAGTGCATCGCCCAGTCCAAGTCCGGTTCGAAGTCCCACAACCGTTAAGCAGGAGCTGTACGACACGGATACGGGCCACTCTGGGGCCGGCGATGATGAGCCAGAGCCCGCCCAGGATGAGGAGGAGTACATAGAGGTGGAGCAGATTCCGCACGAGACGCGACCAAGGGATGTCATGTCACAGCTGGAAAGGGCCACAAACAGCGCCTGA
Protein Sequence: MMALKMLYRGPSSRLENLIEKIQATKEITNNDMYSTHTSSSYSPSISDGTMTPNSHHLAATSANAGQEDLHLTADGKSNGVPGEEPAKPKRQPLFHHHHHHYHHQQALKIANKLRKINKEAKMAAAGAAGAGTGAGAAAKFDKLTGEGIKSRGDGSYQCQFCDKTFPRLGYLKHHVQSHAEHLPFKCEYCAKLFKHKRSRDRHKKLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILAAGGNPNALNYSPRSTGSASASVSSNGSLHKRRYALALATDSSPSRLDFPKRSRSSHVASTPTPTPLLRCSYCPKATEFSSLEQLNAHLQNVHEQTQQPQQQPQLQQQSAKTPVQEGEGFQLSCEYCTMKFGNIAGLFQHMRATHLDRLSSPNSYYEHFNRLATAGTFSPRLALDLPKIKTDLGSPERENRPSEDDLPTDLSSNKRRPQTPNAPPNPPQANAPPGIFFCNQCNAGLPDFESFRNHLKSHIAEGMQLICPHCGLSLPEQSEFERHVVGHFLIPNSEFNCSSSCGKSFGKAEELQQHLITEHVLTLLKCSLCSETCETRMAMQLHLACAHSQETKLLRCSACMEVFRSDGDFHVHVKTRHQLGNHHHPMGGSSSPANPLQCMFCRAVCSSELEMHFHLAAHARQFRCPSCPETFHVEFLLDRHMQSQHGGVKDKEQPPQSSPNMGSLYVNALLPPLAAAAAAAAATNNNSSIIDYNVAFKGLFGGGSAGGSAPTGPSAAGKFYSPLQVDTNALKAQTSPHPALMYGLSQRYLMEMYAAKSTSPANSAANESAGGGTSAINAPPAPQAPPPPAPAVTFSCGMCERQDLRSEAELHSHRKLAHNLKTGVSLRCAYCAGNFKSRAELEQHMKSCHNSTGKHKCLICDEIFPSPAILAEHKLQHSKVGQSGKCAHCSHPLEDVAAFRAHLSEHGSDGASLPLACICCRQTLHSEFELSLHAKFHTKSSSSGGSLQEPVCALCLEPLPGAVEGPTTPAKLCEKCCRKHNLNGKRSKVSEAPVAQAQPTPYMENRCNLCKMILPHAQKLQEHLVEHTFAGTEQRGFNCYICSAVFTAPGGLLGHMAEHGAHSRPYDCNLCPEKFYFRAELEHHQRAHELRPSVRPSLDKPEPPMRGSASPSPSPVRSPTTVKQELYDTDTGHSGAGDDEPEPAQDEEEYIEVEQIPHETRPRDVMSQLERATNSA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00548267;
90% Identity: iTF_00611560;
80% Identity: -