Basic Information

Insect: Drosophila acutilabella
Gene Symbol: ftz-f1_1
Assembly: GCA_035046005.1
Location: JAWNOK010000013.1:9632532-9646079[+]

Transcription Factor Domain

TF Family: SF-like
Domain: zf-C4|SF-like
PFAM: AnimalTFDB
TF Group: Zinc-Coordinating Group
Description: The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 2 2.1e+04 -9.4 25.9 47 160 24 150 4 162 0.52

2 3 1.5e-19 1.6e-15 57.7 0.5 1 79 332 409 332 476 0.79

3 3 3.7e-72 3.9e-68 231.0 1.6 157 408 546 791 519 793 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	2	2.1e+04	-9.4	25.9	47	160	24	150	4	162	0.52
2	3	1.5e-19	1.6e-15	57.7	0.5	1	79	332	409	332	476	0.79
3	3	3.7e-72	3.9e-68	231.0	1.6	157	408	546	791	519	793	0.90

Sequence Information

Coding Sequence: ATGTTATTAGAAATGGATCAACAACAGGCGACTGTACAGTTTATATCGTCGCTGAATCTGTCGCCGTTTAGCATGCAGctagaacagcagcagccagcgAGTCCGGCgcacagcaacaccaacaataacaacaacaacagtggcaacaacaataatagcgccaacaacagcagcagcaacaacaacaacaacgataacgaTACAAATGCATTGAGCAACTCTGATAACGATTACAGCGCCTACACGTTGCAATTGAGTaatcatcagcaacagcagcagcaacaacaacatcacacgcatcaccagcaacaacagcagcagcaacagcaacaacattaccaacaacaacaacagaatattgccaacaacaatgcaaacgCTGCGAATCAATTCAATGCCTCCTCCTACTcgtatatatacaattttgattcACAGTACATATTCCCGACAGGCTATCAGGAGACAAACTCTTCGCACTCACAGCAGAGCGGCAATGGcggtggcaacactggcaacTCTGCTGCCCAGCTTCTGAATGGCAGCACTGcgggtggcaactctggcggCAATGGCTACATGTTGTTGCCGCCTGGTGCAGGTGGCACTTcagcctctgccgctgctgcccaCATGTCCGGCCAAGTTGGCAACCCTGGCAATCCTGTTGGCGGTGCGGGCAGCGGTGCTGGCGGTGGCACGAGTGCTGGCGGTGGTCATCATGGCGGCACCAGTGCGACATCTGGCGGTGGGGAGGCCATTGATTTCAAGCATCTGTTCGAGGAGCTCTGTCCCGTGTGTGGAGATAAGGTGAGTGGCTATCACTACGGGCTGCTCACCTGCGAGTCCTGCAAGGGCTTCTTCAAGCGCACCGTGCAGAACAAGAAGGTCTACACCTGCGTCGCGGAGCGTTCGTGCCACATCGACAAGACGCAGCGCAAGCGTTGTCCCTACTGTCGGTTCCAAAAGTGCCTCGAGGTGGGCATGAAGCTAGAGGCGGTTCGAGCGGATCGCATGCGGGGTGGACGCAACAAGTTTGGGCCGATGTACAAAAGAGATCGGGCGCGAAAACTTCAGGTGATGAGACAGCGACAGTTGGCGCTTCAAGCGTTGCGCAGTTCAATGGGATCGGACATAAAGCCGACGCCATTATCCCCGGGCTATCAGCAAGCATATCCAAATATGAATATTAAGcaagaaatacaaataccTCAGGTATCCTCACTCACACAGTCGCCGGATTCGTCGCCAAGTCCCATTGCCATTGCATTGGGACAGGTGAATGCGAGCGGGGGCGGCGGTGTGATAGCCACGCCCATGAATGccggcaatggcaatggcagctCCTCAATGATCAGtggtaacaacagcagcggcaacaacaacagcaacaacaacagcagcaacaacaacagcagcagcagcacaggcAGCGGTGGTAGCGCTGGCGGTGGAGGTGGCAACAACGCTGgcggtggcaacaacaacagcaacaaccccGATGGCCTGCCACGCAATGGAGGAAACGGCGGTAACGGAGGCAAtggcggcaacagcaacagcagctgccatgAAACCGGAAATGGATCTCTGCAGAATACGGCGGAATCGAAATTGTGTTTCGATTCTGGCTCACATCCATCAAGCACAGCCGATACGCTCATCGAGCCACTGAGGGTATCGCCAATGATACGTGAATTTGTGCAATCGATCGATGATCGGGAATGGCAGACGCAGCTGTTTGCGCTGCTGCAGAAGCAGACGTACAATCAGGTTGAAGTGGATCTCTTTGAGTTAATGTGCAAAGTGCTCGATCAGAATTTGTTCTCACAAGTCGATTGGGCAAGAAACACCGTCTTCTTTAAGGATTTGAAGGTGGACGATCAGATGAAACTGCTGCAGCATTCGTGGTCGGACATGCTTGTGCTTGATCATCTGCATCATCGCATACATAACGGTCTGCCCGATGAGACGCAACTGAATAACGGCCAGGTCTTTAATCTAATGAGCCTCGGTCTACTCGGCGTTCCACAACTGGGCGATTACTTCAATGAGTTGCAAAATAAACTGCAGGATCTGAAGTTCGATATGGGCGATTATGTGTGCATGAAATTCCTAATCCTATTAAATCCAGATGTGCGCGGTATTGTGAACAAGAAGACCGTCTTGGAGGGACACGAGAATGTTCAGGCAGCGCTACTGGATTACACGCTCACGTGTTATCCCTCAGTCAATGATAAGTTTAGGAGGCTATTGAACATACTACCGGAAATTCACGCCATGGCGGCGCGAGGCGAGGAGCATCTGTATTCGAAGCACTGTGCCGGAAGTGCGCCCACGCAGACGCTGCTAATGGAAATGCTGCATGCGAAGAGGAAGGTGTAA
Protein Sequence: MLLEMDQQQATVQFISSLNLSPFSMQLEQQQPASPAHSNTNNNNNNSGNNNNSANNSSSNNNNNDNDTNALSNSDNDYSAYTLQLSNHQQQQQQQQHHTHHQQQQQQQQQQHYQQQQQNIANNNANAANQFNASSYSYIYNFDSQYIFPTGYQETNSSHSQQSGNGGGNTGNSAAQLLNGSTAGGNSGGNGYMLLPPGAGGTSASAAAAHMSGQVGNPGNPVGGAGSGAGGGTSAGGGHHGGTSATSGGGEAIDFKHLFEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAERSCHIDKTQRKRCPYCRFQKCLEVGMKLEAVRADRMRGGRNKFGPMYKRDRARKLQVMRQRQLALQALRSSMGSDIKPTPLSPGYQQAYPNMNIKQEIQIPQVSSLTQSPDSSPSPIAIALGQVNASGGGGVIATPMNAGNGNGSSSMISGNNSSGNNNSNNNSSNNNSSSSTGSGGSAGGGGGNNAGGGNNNSNNPDGLPRNGGNGGNGGNGGNSNSSCHETGNGSLQNTAESKLCFDSGSHPSSTADTLIEPLRVSPMIREFVQSIDDREWQTQLFALLQKQTYNQVEVDLFELMCKVLDQNLFSQVDWARNTVFFKDLKVDDQMKLLQHSWSDMLVLDHLHHRIHNGLPDETQLNNGQVFNLMSLGLLGVPQLGDYFNELQNKLQDLKFDMGDYVCMKFLILLNPDVRGIVNKKTVLEGHENVQAALLDYTLTCYPSVNDKFRRLLNILPEIHAMAARGEEHLYSKHCAGSAPTQTLLMEMLHAKRKV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00485910;
90% Identity: iTF_00585997;
80% Identity: iTF_00470925;