Dacu011445.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila acutilabella
Gene Symbol
Poxn
Assembly
GCA_035046005.1
Location
JAWNOK010000024.1:19588452-19591495[-]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.3e-62 2.5e-59 198.9 1.0 1 125 5 130 5 130 0.99

Sequence Information

Coding Sequence
ATGCCACATACAGgTCAGGCGGGTGTCAACCAGTTAGGCGGAGTCTTTGTTAATGGACGTCCTTTGCCGGATTGTGTGCGTCGCCGTATTGTTGATTTGGCATTATGCGGAGTTCGACCATGCGATATATCCCGGCAACTTCTTGTCTCGCATGGCTGCGTTTCCAAAATTTTAACGCGATTTTATGAGACTGGTTCCATTAGACCAGGATCAATAGGTGGAAGCAAGACTAAGCAAGTTGCCACTCCAACAGTTGTAAAGAAAATCATTCGTCTTAAGGAGGAAAACAGCGGTATGTTTGCCTGGGAAATACGTgagcaattgcaacaacaacgtgtCTGCGATCCCAGCTCAGTTCCATCGATTAGTTCAATTAATCGAATATTGCGAAACAGCGGCCTCTGGACTGACGAAATGACCTCCAgtcaacaaaatgcagcggctgcagcggcagcagcagcagcggctcaTCATTTATCTGGTAGTAGTTCTTCTAATGATTATGGCACGCCTTCGCAGATATATACAAATGCCAGTAACGCTACAGCAAGTGGTATTCGAGCCCCGTCAGCTTCTAGTACGCCGGCCACTTCAACGATATCGGGCTCCTCTTCACGCTACCCTAAACCAACGTCGTCAACGATGGCTGATGCGCAGTCCCTTAAGCCTGCACCAAAGCTTTTACCTAGTCAAGGAAATAGTCACAGCCAAGGACATACCAACACTATGTCTAGCCAATTGGGTGGGTTAGATCTTAGCTATTCGGCTCTACATAAGCACTGGCTTTGGAATCCTTCATTGCTCTACTACACTCAAGCGCATATGCAGGCAGCTCAGGCAGCAGCTACGGGTGGCCCGTTTTTAACATATAATAATACTTATTTGTCGCAAGGAACAGCCAACatagctgctgttgcagctggtAGCTGTTCAGCTGGAGGTGGTTTCACTAAATCGGAAAGCTCAATTGATTTAACGAAACCATGCACAATGAGTGATCCTCTGAGTGATTGTGATTCGGGAAAATCATCGCCATCAGCGTTGTCTCTTATttcaacaaataatataacaGAAACGCTTAGTAATAGGAACAACATTCGCAAAAGGAATCCGTATTCAATTGAGGAACTGTTGAAGAAACCTGACAAGCGTCTCCGCCTTAACAGCGACTTACATGGAAGTTTGGAAAGATCTGCAACAAAGCGTGATAATCATGAAAGTATAAGTTCAAGCTCAAGTTCTTGTGAAAGCAACAGTAGCAGTAATGGAAGCTTAGAGGACGCGACAGCATTGAAGAAGCCGCAGTTGGAAGGCGTTGATATTGAGGAAGATTGCAGTGTGGAGGTGGTCAACTAa
Protein Sequence
MPHTGQAGVNQLGGVFVNGRPLPDCVRRRIVDLALCGVRPCDISRQLLVSHGCVSKILTRFYETGSIRPGSIGGSKTKQVATPTVVKKIIRLKEENSGMFAWEIREQLQQQRVCDPSSVPSISSINRILRNSGLWTDEMTSSQQNAAAAAAAAAAAHHLSGSSSSNDYGTPSQIYTNASNATASGIRAPSASSTPATSTISGSSSRYPKPTSSTMADAQSLKPAPKLLPSQGNSHSQGHTNTMSSQLGGLDLSYSALHKHWLWNPSLLYYTQAHMQAAQAAATGGPFLTYNNTYLSQGTANIAAVAAGSCSAGGGFTKSESSIDLTKPCTMSDPLSDCDSGKSSPSALSLISTNNITETLSNRNNIRKRNPYSIEELLKKPDKRLRLNSDLHGSLERSATKRDNHESISSSSSSCESNSSSNGSLEDATALKKPQLEGVDIEEDCSVEVVN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00478669; iTF_00568925; iTF_00519109; iTF_00608389; iTF_00557857; iTF_00610598; iTF_00575530; iTF_00583627; iTF_00510488; iTF_00528750; iTF_00537459; iTF_00506810; iTF_00522907; iTF_00585916; iTF_00601728; iTF_00601729; iTF_00585138; iTF_00533749;
90% Identity
iTF_00478669; iTF_00568925;
80% Identity
-