Basic Information

Gene Symbol
-
Assembly
GCA_948098885.1
Location
OX402535.1:13480692-13488076[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 8e-13 3.1e-09 36.1 0.0 9 72 158 228 153 230 0.87
2 2 0.017 66 3.0 0.0 28 71 359 401 350 406 0.79

Sequence Information

Coding Sequence
ATGGAAAAATCACACAGAAAGAAATCTATAAAAAATAGTTGTAACCAAAAATCTAATAAACTTTTGTCATCAGAAGATTATTTTATTGGATTTGAATTAAATGATGAAGTATTGAACATTATTGATGAAAAGAGAAAATCTATAAATTTTTATATTATTCAAGAAGAAGGTGGTGTACCTAAGACTGTTGCAATGAATAAAATATGCTCTGATTATATTTTGAATCATTTCAATAGTAAGAAAAAACAATCTAAATCAAGAACTTCTTCTCCTGAAACAAATGATGACATTCAAAATTCTAATAAAAGACTTAAATTAGACGTTTCTAATGAAACGGTGGAATCTTTGGATGAGGATGTTCCTCCTAGTTTAGAACTCACAACTCCAACATTTAACCTTACCTCTGCTACATCTAAGGCACGCCGTAGTGTTCGAAAGGTTAATGTTGATATTAGTGATCCAATTTTCAAACTTCCTTTTGAATATGGATGGAAGCGAGAACTTGTTTATAGAACTTCAGGCGAGTCTACAGCTTCTAATCGAGTTAATCGAAATGGTGATGTATACTATTATTCTCCCCTTAATCGGAAACTTCGGTCATTAAGAGAAATTCAGGAACAATTAGATTTATCACTAAATGACAAATGTCCTTTAACAATAGAAAGTTTTACCTTTTTAAAACAGCCTATTGGTATAAATGATAGATCCAAAGAACTGATTAGAGATGCAAACACTAAATTATCTAAAGAAGATTCCTTTGTTGGTGTTAGTGTTCGACCTAAAAAACCAAAAACCCCTGTACAGCAACCATTTGAATATGAAATGTCAGATACTGACAATAATAAGTCGTCAAATAAAATGAAAATTGTCTTTAAAAATGTCAAACAGTCGCCAAGATCAAAATCCAAATCCAAACGGGATAAAAGTAATTTAGAAACACTAAACACATCTTCATCTACACCAGAATATTTAAGTGAAGATTGTCAAGCTATTCAATCTAGTGAAACACCAAAAACTTCCCCTTCAAAAACTGATGATGAAACAAATGTTGAAAACATTGATAGACGGTTATCAGCATCAGATGGGGAAGTCATCATGCAGGCCCCATGTGGGATACGTTGCCCTAACAGCAATGAACCAGCTACCTTAATGTGTGCCCAATGTCTGGTCTACTATCATCCAGCTTGTGTCAATTTAAATGCTAATCTAAAAATTGTTGGTTATGTGTGCATAAATTGTCGATCCTATGTACGGCAAAGAAATAGGCGAGTACAATCATCTCATACTGTAGTTGTTGGTGCTTCTGAATCTGAACAATTACGTGTGGAACCAATTCGCATACGACAAGTTCATCAAGCATCAGATACACCTAATTTTTTTATTGATAGAACACCAATTATCAAAAATGATGAACCTGATTATGAAAGTGATGAACATTTTGATGACAATAACTCTGTTATAAATACAGTAACATGTCAAGGAAATGTTTATGAAACTTTAATGGTTGATGGAAATTTTCATGAACAATATGTTTATGAAATGAAACAAACACGAGGTCCTAGTTTGATGACCTGTGTTGTTCAAGAACCTAAAAATTTAGATGAAAATTCTGAAAAAAATGGTTCACTAAAAGAAATGCCTAATTCAATGGACATTATGCTCATATACAATTGCATGGGTGTAGCAATGAGACATGTTTTCAAGTATTTAAAAATACAGGACCTTTTATCAGCTTCCCGGGTGTGTACTTCTTGGAATTTAGCGGCAATGGATCGACGTTTGTGGAAAAGTGTTTGTTTAAAAAATTCTATGGTATATGATTGGGATCAATTTGTAGAATCAATAAATTATCAATGGACACAATCATTGGATTGTAAACGTATGTTAATTCCTACAAGATTTGAAAAATTTGAAGATTATTGGTTGCGCTTTTCAAAGGCTATAAAAAAAGCAACACGATTAAAAGTTATTGAATTATATAGATGTCCACCGCATATAGTTGAAGATATAATTTACTCATTACCTCAACTTGTAATACTTAAATCAACTTCATTAAAGAATCCAATTTCTTTGAAAGATCCTAGAAATAATGAATTTATGACTCTAAACCTAGCATATGTGGGTCAATTAGCTAACCTGATTGAATTAAGGCTTAAGGGTCAAAATGGATTAAGGTTGACACCTATACCAACATTTATAAATTTAAGAAATTTACAAACTTTGTCATTAACCTCCGTAAAATCATTTCCAAAAGATTTCTGTCGTTCTTTGGAAACTGTAACTTCAGGCTTAAAGATTTTCGAGATTGGAGACTGTGATCATTTATTCAAAGACTTTGCTGAAGTACTAAAAAGATTTACCAATTTAACTTCTTTGAGGTTAGAAAATTGTTGTGGCAAATGGGACACTTTTGCAGTAGATGTTTTTGGTGCAATTAGAAGTCTGAAAAAGCTCAAGGTTTTGGAACTAATTAACATCGAATTTAGTAGTAATGTAGAAGAAGAATTGGAGAAATGTTGTGATATTAGAGGTTTAGTAATAATACCTTATTACATAAGCCAATCTGCAACTACTAACTATAACTTGGTTGACTGTCTCAAGAAACTCTCTAAAACCTTAACCCATCTAGTATGGGGATTGACCAATGAGTTACTACGTGTTACAGAACTATTTATTACTCAATATCAAAAAAATATTGCTAATGGTAGCAACAAATTAGAATTACCATTTTCAAATGATACTTCTAATAACATACCTATACTGAGAGCCAGAAGGCCAAAACTACGACTCGGAGAAGAACCTGTTGTAGAAAACGAAAAAGACAAAGACAAATCCGACAATATTGATAtactttcaattccagctctgcaaaatttattagatacaacgatgatacatactaaatgcaaagtaatcaagactcccttttcagggacaactagaatttgtttagcagatcattataatgatatttga
Protein Sequence
MEKSHRKKSIKNSCNQKSNKLLSSEDYFIGFELNDEVLNIIDEKRKSINFYIIQEEGGVPKTVAMNKICSDYILNHFNSKKKQSKSRTSSPETNDDIQNSNKRLKLDVSNETVESLDEDVPPSLELTTPTFNLTSATSKARRSVRKVNVDISDPIFKLPFEYGWKRELVYRTSGESTASNRVNRNGDVYYYSPLNRKLRSLREIQEQLDLSLNDKCPLTIESFTFLKQPIGINDRSKELIRDANTKLSKEDSFVGVSVRPKKPKTPVQQPFEYEMSDTDNNKSSNKMKIVFKNVKQSPRSKSKSKRDKSNLETLNTSSSTPEYLSEDCQAIQSSETPKTSPSKTDDETNVENIDRRLSASDGEVIMQAPCGIRCPNSNEPATLMCAQCLVYYHPACVNLNANLKIVGYVCINCRSYVRQRNRRVQSSHTVVVGASESEQLRVEPIRIRQVHQASDTPNFFIDRTPIIKNDEPDYESDEHFDDNNSVINTVTCQGNVYETLMVDGNFHEQYVYEMKQTRGPSLMTCVVQEPKNLDENSEKNGSLKEMPNSMDIMLIYNCMGVAMRHVFKYLKIQDLLSASRVCTSWNLAAMDRRLWKSVCLKNSMVYDWDQFVESINYQWTQSLDCKRMLIPTRFEKFEDYWLRFSKAIKKATRLKVIELYRCPPHIVEDIIYSLPQLVILKSTSLKNPISLKDPRNNEFMTLNLAYVGQLANLIELRLKGQNGLRLTPIPTFINLRNLQTLSLTSVKSFPKDFCRSLETVTSGLKIFEIGDCDHLFKDFAEVLKRFTNLTSLRLENCCGKWDTFAVDVFGAIRSLKKLKVLELINIEFSSNVEEELEKCCDIRGLVIIPYYISQSATTNYNLVDCLKKLSKTLTHLVWGLTNELLRVTELFITQYQKNIANGSNKLELPFSNDTSNNIPILRARRPKLRLGEEPVVENEKDKDKSDNIDILSIPALQNLLDTTMIHTKCKVIKTPFSGTTRICLADHYNDI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-