Basic Information

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 1.7e-61 5.4e-58 194.0 0.1 2 128 22 150 21 151 0.96

2 2 0.4 1.3e+03 -1.2 0.0 11 30 319 338 316 340 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	1.7e-61	5.4e-58	194.0	0.1	2	128	22	150	21	151	0.96
2	2	0.4	1.3e+03	-1.2	0.0	11	30	319	338	316	340	0.88

Coding Sequence: ATGCCTTTGGACATATTGGAGGACGTGGACGCGGTCTACCAAAAATACGTGTCGTGCATCCTGGAGGACGTGCGAGCCATCCACGGCAAAGAGATGGTGGCCACGGGCAGCCCGTCCGTGTTCTGTTCCGTTCTGCCCGGCCACTGGCGATCCAACAAATCGTTGCCGATACCGTTCAAAGTGGTCGTGTTGGACGAGGTGCCCGACGGCGCGGTCGTTGTCGTGCAAGCCGGCAACGACGAGAACCCGTCGGCCGACATGCGAAATTACCGGGCCCTGTCGGCCACCGGCGTGGCCGTGTTCAACGATCTCCGGTTCGTCGGCCGCAGCGGAAGAGGTAAACTGTTAACGCTCACCATTACAGTTCAATGTAAAGACCAAGTAGTATTAGTTGCCAACTACGTGAAAGCCATTAAAATCACCGTCGATGGGCCTAGACTTCCCCGGTCAAATCACAGAGACGTGATCCACGGCTACGGCGGCATGTTCCCCATGCACGGTCCCCTGCCGCCTTACGGCATGATCATGGAGTACAAACGACTGCTGGAGGGCGCGGCGTTGCCGGGCTCGCTCAACTACCAGTACATAGCGGCCAATTACTTTCAACTTCACAATGCCATGGAAGCGTCGCAGATGTACTGCGACATGCCGCCCCAGTCGGCGTTCAATTTCGCCGGCTACAACCACAGTTTGCCGCCCACGCCGCCGCACACGGAGGAAGAACCGCCGTCCGTGGCCGCCGGGGCGCAGGACGACTGCTGCGGAACCGCGGTCCCCTCGAAACGACCCGCGGCCGAGCCGGCGGCGGCGACGGCTCCCACGACGACGGCGACGACGACCGCCGCCGCCGCCGCCGCTCAGGGCGATAACGGCCGGACGTCGCACCACCGGACGCACCAAGAGCCCAAACGGCCCAAGCGCGAGTCCGCTCCCAGCCCCGACATCGACATCGTCAACGTGGTCCGGTCGTCCAGTCCGGAAGTGCTGAAACCCCGGCAGGAGAAGATCTGGAGACCCTACGGCGCCGCCGACGAATAG
Protein Sequence: MPLDILEDVDAVYQKYVSCILEDVRAIHGKEMVATGSPSVFCSVLPGHWRSNKSLPIPFKVVVLDEVPDGAVVVVQAGNDENPSADMRNYRALSATGVAVFNDLRFVGRSGRGKLLTLTITVQCKDQVVLVANYVKAIKITVDGPRLPRSNHRDVIHGYGGMFPMHGPLPPYGMIMEYKRLLEGAALPGSLNYQYIAANYFQLHNAMEASQMYCDMPPQSAFNFAGYNHSLPPTPPHTEEEPPSVAAGAQDDCCGTAVPSKRPAAEPAAATAPTTTATTTAAAAAAQGDNGRTSHHRTHQEPKRPKRESAPSPDIDIVNVVRSSSPEVLKPRQEKIWRPYGAADE

Sequence clustering based on sequence similarity using MMseqs2