Basic Information

Gene Symbol
-
Assembly
GCA_016069955.1
Location
JACCPG010011435.1:2499-7280[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 20 0.03 2.6 9.1 1.8 1 23 42 64 42 64 0.95
2 20 0.26 22 6.1 7.3 1 23 93 115 93 115 0.98
3 20 0.0017 0.14 13.0 0.1 1 23 140 162 140 162 0.95
4 20 5.6 4.8e+02 2.0 4.4 5 23 170 189 167 189 0.93
5 20 0.0001 0.0086 16.9 0.1 3 23 245 265 243 265 0.98
6 20 2.4e-05 0.002 18.9 0.3 1 23 271 293 271 293 0.98
7 20 4.8e-06 0.00041 21.0 0.7 1 23 299 321 299 321 0.98
8 20 1.1e-06 9.6e-05 23.0 0.9 1 23 327 349 327 349 0.99
9 20 0.00041 0.035 15.0 0.3 1 23 355 377 355 377 0.98
10 20 0.00025 0.021 15.7 4.7 2 23 384 406 384 406 0.96
11 20 1.1e-07 9.6e-06 26.2 0.6 1 23 412 435 412 435 0.98
12 20 0.026 2.3 9.3 0.2 1 19 440 458 440 463 0.91
13 20 0.0022 0.19 12.7 0.5 1 23 463 485 463 485 0.95
14 20 0.41 35 5.5 0.4 1 23 490 513 490 513 0.91
15 20 0.031 2.7 9.0 0.1 2 20 517 535 516 537 0.93
16 20 1.3 1.1e+02 4.0 2.1 2 14 541 553 540 556 0.83
17 20 0.00042 0.036 14.9 0.1 2 23 576 598 575 598 0.95
18 20 0.036 3.1 8.8 0.5 3 21 604 622 602 623 0.91
19 20 0.0011 0.091 13.7 0.0 2 23 629 650 628 650 0.95
20 20 0.00046 0.04 14.8 3.8 1 23 655 678 655 678 0.96

Sequence Information

Coding Sequence
ATGAGTAACCCTTCCTTCAAAAGAAAGCTGACTACAACACAATTAAATAATGCGGTCACATATCGCCAAAGTATCATGAAGCTCAACTCGGAAGTAATTATCAAAATTGAAAAGGTTGCCATCCATCCTTGCAGTGTGTGTCCTAAAGCGTATACGTGCTTAGACGACTACAATAAGCACATAACTGAACATGATCCAAGTAATATTGACTTGAAAGATGCCCATATACTGAAGCATATAAAAAGTGCATATGTATATCTGGACCGCTCCAAATCCTTCCAATGTGAGCATTGTGGTGACAGCTTTCAGCACTGCAGAGATTATAAATTGCATAAATTGATTCACATACAACAAGCTGCAAATGTCCTCCTTAAAGCCAGTAAACACAATAATAATGATAGTCGCTTTGTCAAGTTATATAAATGTTCAGAATGTGATTCACGTTTTGTTGCAAGGAGCACTCTGATCGCCCATGCGGAGGCCCATGAGCCTCGCTCACATGTGTGTCACTGTGGCATTGGCTACTTCAAGAAGTGTGACCTGAACTCCCATAGGAAACTGGTGCACCCCGATTACAAGGAACCTGAGGTGAAAGTACAAGTAAAAGAGATCATTAAAACAAAATTAGGTTCCTATTTGTCTCCAAAGTTTAATTCCAAAGCGAAATCAAAGAAAGTAAAACGGAAAAATGGTCAGAGAGATAAAAAAGCTCCAACAGAAAGGAGGTTTGGTTGTCCAGTTTGTGAGAAGACTTTGGCCAATAAAAGAGGTTTGATAGTACATCTACGCACGCACACCGGTGAGAAACCATACCCTTGTGGGCTGTGTGGTAAGAGGTTCGCACAGGCCTCCACACGAACAATACATTTGAAACGACACGCAGGTGTTAAGGACTTTGAGTGTGAACATTGTGGAAAAAGTTTCTATATGAAAGGTGCATTGGACTTGCATTTGCGTGTTCACACCAAGGAGAAGCCTTACAAATGTATGTATTGTGAAAAGGCTTTCAGTGACCCCTCCGCCCTGGGGCGCCATCACCGCATCCACACCGGCCTCAAGCCCTACCAGTGCCCACTGTGTCCTAACAAGTACAGCGATATGAGCGCCCTCGTCACCCACAAGCAACGCCACGTGAACTATAAAGCAGCTGAGTGTGAGTTGTGCCACAAAAAGTTTCCCAGCAAGCATAATATGAGGAACCATCTGAAAGTAATGCATACGAATATTAAGGACTATGAATGCTCAGAATGTGGCAAAACATTTGCTCTGAAATCATATTTGAAAACACATATACGGATCAGTCACATGCCGAGGCAATATCGTTGTTCTTATTGCGGGGAGGACCTCGGTAGCAAGGCCAGCCTGGCAACCCACTGCGGCACAGTTCATAACTGCGCAGAGTGCAAGCGGGGCTTCCCTAGCAATTCACACATGGTTGGACATATTCTCTACCACCCCGGCGCTTGGTTCGAATGTGACGAATGCGGTGCGGATTATAACGCAAAAACTATATTGCATCAGCATATTGCTAAAAAGCACTCTAATATACGCTGTAACGTGTGTTCATGGCGAGTAATGTCTAAAAGTGAGCTGGTCAAACACAAAGAGAGGGGTTGCCTCAGGTGTAAATATTGCAATCGTGGGTACACGAAATCACACGCATGTAGATGGAAACATTCCAAGCCGAGCAAGACGAAGAAACGTCCAAAAGTGGGTTTAAAATTAGTGTGTGATTCCTGTGGACAAGGTTACTCTAGTAAGCAACTTTTGGTAAATCACATAAGATTAGTCCACACTGTAACATTATTCTGCAGTGAGTGTCCGGAGAAATTTTATAGCGATGAGTTGTTCCAACGCCACAAGCTGAAAGGATGTAAGCAAATGGAGTGTGAGATATGTGGGGAGGTCGTCTTTTCGCAGAGAAATTATGAAAGGCATCTGGAGGCGCACTCTGGGTTCAGACACAAGTGCCACAAATGTGATAGATCTTTTGGCAAGGAAGATGTCTTAAAGAAACATTTGATTGTTCGACATGGGCTCAACTAA
Protein Sequence
MSNPSFKRKLTTTQLNNAVTYRQSIMKLNSEVIIKIEKVAIHPCSVCPKAYTCLDDYNKHITEHDPSNIDLKDAHILKHIKSAYVYLDRSKSFQCEHCGDSFQHCRDYKLHKLIHIQQAANVLLKASKHNNNDSRFVKLYKCSECDSRFVARSTLIAHAEAHEPRSHVCHCGIGYFKKCDLNSHRKLVHPDYKEPEVKVQVKEIIKTKLGSYLSPKFNSKAKSKKVKRKNGQRDKKAPTERRFGCPVCEKTLANKRGLIVHLRTHTGEKPYPCGLCGKRFAQASTRTIHLKRHAGVKDFECEHCGKSFYMKGALDLHLRVHTKEKPYKCMYCEKAFSDPSALGRHHRIHTGLKPYQCPLCPNKYSDMSALVTHKQRHVNYKAAECELCHKKFPSKHNMRNHLKVMHTNIKDYECSECGKTFALKSYLKTHIRISHMPRQYRCSYCGEDLGSKASLATHCGTVHNCAECKRGFPSNSHMVGHILYHPGAWFECDECGADYNAKTILHQHIAKKHSNIRCNVCSWRVMSKSELVKHKERGCLRCKYCNRGYTKSHACRWKHSKPSKTKKRPKVGLKLVCDSCGQGYSSKQLLVNHIRLVHTVTLFCSECPEKFYSDELFQRHKLKGCKQMECEICGEVVFSQRNYERHLEAHSGFRHKCHKCDRSFGKEDVLKKHLIVRHGLN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00468343;
90% Identity
iTF_00468343;
80% Identity
-