Basic Information

Gene Symbol
setdb1
Assembly
GCA_016069955.1
Location
JACCPG010000396.1:18415-37902[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 0.64 3.8e+03 -2.0 0.0 4 19 901 916 900 918 0.84
2 3 0.46 2.8e+03 -1.6 0.0 28 38 986 1008 970 1010 0.65
3 3 9.6e-12 5.7e-08 32.7 0.1 4 53 1040 1084 1037 1089 0.89

Sequence Information

Coding Sequence
ATGGAAGGAGTTGCATCAGAGGCGCCGACAAGAGCTCAGCTCTTAAAGCAAAGGTGTCTGTCATGGCGTATAGGGAGGTCAAAGAGATTGCGCTGGACAGAGGCAAATGGAAGGAGTTGCATCAGAGACGCCGACAAGAGCCCAGCTCTTAAAGCAAAGGTGTCTGTCATGGCGTATAGGGAGAACCTGATCAACGGTATCAAAGCGCTGACTCCTCTCTTAGACTTGGCCATGGAGCAAGAGTCAGAGGACTTAGTGGAGATATCCGACTCGGAGTCGGAGGACGAGGCCGATGTCCACGACGAGCCCAAAGAGACCATCGGCGTAGAGGGGGCTAAGTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCTCTGGCGGAAAATTACTGGAAGAGAACCTGGCGAATGTCATCAATGAAACGTGGGAGAAATACAATATGGACACGCGCTTAAAGGACACACAAGACATTTTGGACACTGAGATTCATAAGCTAGAGATGGAGAGTGAAGAAATTGATATGATGCTAGCGGAATGCCAGGTGGCGACGGATAAGCTCAGATCGGATCTGTACTCCACATTCCGCTGCAGGAGGAAGCAGCTTACGGGTCTTATTATCTGCGACACTCCATATGCCGAGTACTCTGTGGTAGAGGAAGCAGCGCCTGTAGCCGAAAGTGAGATCCGTGAGCCTAAGCGGCGTCTATCGTCCGGTGACGACATGCCGGCCAAGCGGCCACCCATCCCGTTGGGGTACGCGCCTTTGGACGACTCCAACGCTGTACAAAATGTAGACGAATGCAAGAGCCCTGGTCCAGATAGTGATATATCGACTAAAGATGACGACGATAAGGACATATCCGTCGTGAAGTTGTCCGCGGAGGCGGCGCCGCCGGACCTGCCGCCGCGGGCGGCGGGGGAGCCCCCCCGGGCGCCGCTGCGGCCCGGCATGGAGGTGTACGCCATGAAGAATGCCTTCGGCGCCTGGCTCAGGGCCAAGGTGGTGGAATGTCAGCCCAAGGCTGCAAATATGGAGTGGACTATGTGCGGCGTGACCTTCGTGGACAAAGTGAAGATTCCTACCAAGGTCATAGCGGGCCGGTGTCTCGCCTACTCCCATCCCTCCGAGTACAGGATGACCATTGGTACGCGTGTGATAGCCCTGTTCAAGGACACAGCGAACGCGAACAAACGCGATTCCTTCTACTCGGGCATAATCGCCGAGATACCGAACCCTGTCAATAATTACAGGTGTTACATCCGGCACGCCGACACGCGGCTCGTGTGCGAGTCCTCGACTGTGGTGTGGCAGGACATGCACCCCTTCTCCAGGAGCTTCGTGCGCGACTACCTCACGGCCTACCCCGAGCGACCCATGGTGCGCCTGCACGCGGGCCAGAAGCTCAGGACGGAGTGGAACGCTGCCCGACTGGGGCAGGACCTCCACCTTATAGAAGTCCGTAGACAAATAACACAATTTATTGTGTTGTGTTCCTACGCGGTGAATAAGGTTTCCAGTAACGAGCTCCTTGGGGAGGGGGAGGTCCGTGAGCCTAAGCGGCGTCTATCGTCCGGTGACGACATGCCGGCCAAGCGGCCACCCATCCCGTTGGGGTACGCGCCTTTGGATGACTCCAACGCTGTACAAAATGTAGACGAATGCAAGAGCCCTGGTCCAGATATTGATATATCGACTAAAGATGACGACGATAAGGACATATCCGTCGTGAAGTTGTCCGCGGAGGCGGCGCCACCGGACCTGCCGCCGCGGGCGGCGGGGGAGCCCCCCCGGGCGCCGCTGCGGCCCGGCATGGAGGTGTACGCCATGAAGAATGCCTTCGGCGCCTGGCTCAGGGCCAAGGTGGTGGAATGTCAGCCGAAGGCTGCAAATATGGAGTGGACTATGTGCGGCGTGACCTTCGTGGACAAAGTGAAGATTCCTACCAAGGTCATAGCGGGCCGGTGTCTCGCCTACTCCCATCCCTCCGAGTACAGGATGACCATTGGTACGCGTGTGATAGCCCTGTTCAAGGACACAGCGAACGCGAACAAACGCGATTCCTTCTACTCGGGCATAATCGCCGAGATACCGAACCCTGTCAATAATTACAGGTACCTGGTATTCTTCGACGTGGGCTCGGCGCAGTACATCCGGCACGCCGACACGCGGCTCGTGTGCGAGTCCTCGACTGTGGTGTGGCAGGACATGCACCCCTTCTCCAGGAGCTTCGTGCGCGACTACCTCACGGCCTACCCCGAGCGACCCATGGTGCGCCTGCACGCGGGCCAGAAGCTCAGGACGGAGTGGAACGGTCAATGGTGGAGCTCGTGCGTGGTGCAGGTGGACGCGTCGCTGGTGGAAGTGCACTTCGCGGGCGACGGGCGCCGCGAGTGGATCTACCGCGGGTCCACGCGCCTCGAGCCCTTGTACAACGAGCTGCAAGTGGCGCAGCGGCACAAGCATCGCGCCTTGCCGAGGAGCAAGGCACAGCCCAGGGTAAGCAGCTTCTGGAGAGATGCTTGCACGTGCTTGGAAGGGGATGTTGAACAAGATAATCTTCGATGCCACAGACTGTTCGCAGTGGGCACACATCGCAAAGTATCACGTGCACACTCCCCTGTACCTCGCACTCTCACTGCACTCAGTGCCCTCTTGGAGTCCAACCCTGACTGTGACGTGTTCAAGGACGGATGGAAGGCTATCATGGCGGCATGGCTGGACTATTGTGAGATGAGTAGCAACCTTCCGGCGCCGTACGTGGAGTACACCCGGACTGACGAGCAGGGAAGCAGTAAGGTACACACCACCCAGGAGCAGCCGCCGCCGGTGGCGACGCCGCAGCAACAGAGGCATACCGAGGAACTGCGTCGCCAGCGTGCGGTGGCTAAGAAATCCACCTCAGCTTCTTCATCAGCGCCGCCCACAGCATCCACGGGGAGCAACCTCGACTCAGTCACCAGTCGAGTTGTGTATTATACACCCAAAAACGCGGTGAAACCCTACAAAATGACGGCGCACACGTGCGGACCAAAGTGCAAGCGGAGCGATGTTCTCGCCCTCAAGGACCTTCGCACCTACAACCCCCTGGCAAAGCCCCTCCTCAGCGGCTGGGAGAGGCAGCTGGTACGCTACAAGGGCCACAAGGAGGTGATGTACCGCGCGCCGTGCGGCCGGCGCGTGCGCAGCATGGCCGAGCTGCACCGCTACCTGTGTGTGTGTGTGTGTGTGTGTAACCTCAGTGTGTGGGCGGCAGGC
Protein Sequence
MEGVASEAPTRAQLLKQRCLSWRIGRSKRLRWTEANGRSCIRDADKSPALKAKVSVMAYRENLINGIKALTPLLDLAMEQESEDLVEISDSESEDEADVHDEPKETIGVEGAKXXXXXXXXXXXXXXXXXXXXXXXXXSGGKLLEENLANVINETWEKYNMDTRLKDTQDILDTEIHKLEMESEEIDMMLAECQVATDKLRSDLYSTFRCRRKQLTGLIICDTPYAEYSVVEEAAPVAESEIREPKRRLSSGDDMPAKRPPIPLGYAPLDDSNAVQNVDECKSPGPDSDISTKDDDDKDISVVKLSAEAAPPDLPPRAAGEPPRAPLRPGMEVYAMKNAFGAWLRAKVVECQPKAANMEWTMCGVTFVDKVKIPTKVIAGRCLAYSHPSEYRMTIGTRVIALFKDTANANKRDSFYSGIIAEIPNPVNNYRCYIRHADTRLVCESSTVVWQDMHPFSRSFVRDYLTAYPERPMVRLHAGQKLRTEWNAARLGQDLHLIEVRRQITQFIVLCSYAVNKVSSNELLGEGEVREPKRRLSSGDDMPAKRPPIPLGYAPLDDSNAVQNVDECKSPGPDIDISTKDDDDKDISVVKLSAEAAPPDLPPRAAGEPPRAPLRPGMEVYAMKNAFGAWLRAKVVECQPKAANMEWTMCGVTFVDKVKIPTKVIAGRCLAYSHPSEYRMTIGTRVIALFKDTANANKRDSFYSGIIAEIPNPVNNYRYLVFFDVGSAQYIRHADTRLVCESSTVVWQDMHPFSRSFVRDYLTAYPERPMVRLHAGQKLRTEWNGQWWSSCVVQVDASLVEVHFAGDGRREWIYRGSTRLEPLYNELQVAQRHKHRALPRSKAQPRVSSFWRDACTCLEGDVEQDNLRCHRLFAVGTHRKVSRAHSPVPRTLTALSALLESNPDCDVFKDGWKAIMAAWLDYCEMSSNLPAPYVEYTRTDEQGSSKVHTTQEQPPPVATPQQQRHTEELRRQRAVAKKSTSASSSAPPTASTGSNLDSVTSRVVYYTPKNAVKPYKMTAHTCGPKCKRSDVLALKDLRTYNPLAKPLLSGWERQLVRYKGHKEVMYRAPCGRRVRSMAELHRYLCVCVCVCNLSVWAAG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-