Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.012 15 7.2 0.3 24 48 29 53 24 57 0.91

2 6 0.61 7.6e+02 1.8 0.1 25 44 61 80 50 84 0.80

3 6 0.088 1.1e+02 4.5 0.1 21 52 111 142 104 144 0.88

4 6 0.0083 10 7.7 0.0 20 43 166 189 151 195 0.90

5 6 0.0082 10 7.8 0.1 22 44 196 218 190 222 0.84

6 6 0.031 39 5.9 0.3 21 48 223 250 220 255 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.012	15	7.2	0.3	24	48	29	53	24	57	0.91
2	6	0.61	7.6e+02	1.8	0.1	25	44	61	80	50	84	0.80
3	6	0.088	1.1e+02	4.5	0.1	21	52	111	142	104	144	0.88
4	6	0.0083	10	7.7	0.0	20	43	166	189	151	195	0.90
5	6	0.0082	10	7.8	0.1	22	44	196	218	190	222	0.84
6	6	0.031	39	5.9	0.3	21	48	223	250	220	255	0.92

Coding Sequence: ATGTTTAAATGTAATCACTGCGATTACAAGAGTTACAAGGTCCACACTATGAGGCAGCATGTTTTTATGCATACCAAGAGAATTCCAATCGCATGTAAAATATGCGAACAAAAATGTATCGACTCGAACAGTTTGAGAAAACACATGAGGAAGAAGCATTCGACGGAAGTTAAAGAACAGCTCGTATGTGAGATTTGCGGTTATATAACGGATGAACCCTCGTATCTCAGGAGGCACACCAACGAACATGAGAAATCGTATCAGTGCGAGCGCTGCGGCAAGGTATTCACCTCACGTTACGGTTTGATGTCGCATATGAGGACGCATACCGGGGAGAAACCGTATAAGTGCAaaatttgcgattataaatgcgccCAGGGCTGTCAGCTCTGGACACATATGAAGAAACATACCGGCGCGAAGCCCTATCAGTGTGACAAATGCGAATTTAGAGCTGCCTTAAAAGGTAACCTCAAGAAGCACATTGCGTTACATTCCACAGAAAAGCCGTTCAATTGTGACATCTGCGATTTTAAGACGAAAACCTCCACGGACTTAAAAAGGCACAAAAGAACGCACACAGGCGAGAAGGCATTCGAATGCAGTACATGCGCTAAAAAATTCACTAGCTCCAGAAACTTGAAAAGGCATGTCTTAATACACGCAGGGGAGAAACCGTTTGCGTGTAATTTATGTGATTACAGATCTACTCAGCGGTCCAACGTGAAAGTACACATGAAACACAGACATAAGGAAagtaaaaatactgtaaataaaattgaagcaaCTTAA
Protein Sequence: MFKCNHCDYKSYKVHTMRQHVFMHTKRIPIACKICEQKCIDSNSLRKHMRKKHSTEVKEQLVCEICGYITDEPSYLRRHTNEHEKSYQCERCGKVFTSRYGLMSHMRTHTGEKPYKCKICDYKCAQGCQLWTHMKKHTGAKPYQCDKCEFRAALKGNLKKHIALHSTEKPFNCDICDFKTKTSTDLKRHKRTHTGEKAFECSTCAKKFTSSRNLKRHVLIHAGEKPFACNLCDYRSTQRSNVKVHMKHRHKESKNTVNKIEAT

Sequence clustering based on sequence similarity using MMseqs2