Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.028 36 6.0 0.1 25 44 18 37 12 45 0.84

2 9 0.0064 8 8.1 0.0 21 44 42 65 39 71 0.90

3 9 1.3 1.6e+03 0.7 0.0 22 49 92 118 86 122 0.79

4 9 4.9 6.2e+03 -1.1 0.1 22 44 148 170 146 178 0.79

5 9 0.12 1.5e+02 4.0 0.0 23 43 177 197 171 203 0.89

6 9 0.011 14 7.3 0.0 21 45 203 227 201 235 0.90

7 9 0.00066 0.83 11.3 0.1 21 52 237 268 231 270 0.89

8 9 0.00041 0.52 11.9 0.1 23 44 267 288 262 292 0.89

9 9 0.002 2.5 9.7 0.2 21 48 293 320 289 321 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.028	36	6.0	0.1	25	44	18	37	12	45	0.84
2	9	0.0064	8	8.1	0.0	21	44	42	65	39	71	0.90
3	9	1.3	1.6e+03	0.7	0.0	22	49	92	118	86	122	0.79
4	9	4.9	6.2e+03	-1.1	0.1	22	44	148	170	146	178	0.79
5	9	0.12	1.5e+02	4.0	0.0	23	43	177	197	171	203	0.89
6	9	0.011	14	7.3	0.0	21	45	203	227	201	235	0.90
7	9	0.00066	0.83	11.3	0.1	21	52	237	268	231	270	0.89
8	9	0.00041	0.52	11.9	0.1	23	44	267	288	262	292	0.89
9	9	0.002	2.5	9.7	0.2	21	48	293	320	289	321	0.94

Coding Sequence: atgAGACATGGTATAAACGACCAAGATCCTTTATGCACCGAAGCAAAGTCGATCACCTGCGATAGttgtgattataaatgtcgCGATTCCCGCAAgatgaaacggcacaagttcatacataccggcgagaaaccgtatAGTTGCGGCCTTTGCCATTATACCACCGGAAGGAGTAGCAATTGGAAAAGGCACTTGTTAACACACACCGAGAGAGAAATCTCGAGTTGTGATCAGAAGCTTCGACTTAGCGCAGATTTGTCGAATAGAGCCGACGAGAAGTTGTTCACTtgcggtctttgcgattacgaaGGGCGAGATCGCAAAGAGTTGAATCAGCATACATTATTACACTTTGACAGGAAATCTCTGAGTTGTGATGCTTGCGATTTCAAATGCCGAGATGAGATCGTCTTAAAAAATCATAAGTTAGCTCACATCGTCGAGGCACCGTTGATTTGCggcctttgcgattataaatgccgactgCGCACGgttttgaagcagcacatgctGACGCACACCGACGTTAAGCCGTTCAGCTGCAACCTTTGCGATTCCAAATTCAGGCAGAAAGGTCATCTGAGAGTCCACAAGTTAATACATACTGGCGAGAAGCCACACAGTTGCAGCTTATGCGATCACAAGTCTCGATCTAGCGGAGGTTTGAAGAAACACATGGAAAGCCACCTTGACAAGAAATACCGAAACACTGAAAAAACGGCCGCTTGCCGCCTTTGCGATTTGAAGTTCAAAAGATTGACGAATTTAAGACGGCACATGTTGACACATACCAACGCAAAGCCATACAATTGCGAGATTTGCCATTCCGCGTTCAGACAGTCTGGGCACTTGAAGCAGCATATGCtgatacacaccggcgagaagccgttcagttgtgattcttgcgattacaagtgccgatCTAACGGAGACTTGAGAAGGCACGTCAAAGCACgtcattcttaa
Protein Sequence: MRHGINDQDPLCTEAKSITCDSCDYKCRDSRKMKRHKFIHTGEKPYSCGLCHYTTGRSSNWKRHLLTHTEREISSCDQKLRLSADLSNRADEKLFTCGLCDYEGRDRKELNQHTLLHFDRKSLSCDACDFKCRDEIVLKNHKLAHIVEAPLICGLCDYKCRLRTVLKQHMLTHTDVKPFSCNLCDSKFRQKGHLRVHKLIHTGEKPHSCSLCDHKSRSSGGLKKHMESHLDKKYRNTEKTAACRLCDLKFKRLTNLRRHMLTHTNAKPYNCEICHSAFRQSGHLKQHMLIHTGEKPFSCDSCDYKCRSNGDLRRHVKARHS

Sequence clustering based on sequence similarity using MMseqs2