Basic Information

Gene Symbol
-
Assembly
GCA_958336345.1
Location
OY284475.1:7683633-7684682[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.0005 0.046 15.6 0.7 2 23 18 39 17 39 0.97
2 12 6.7e-05 0.0062 18.3 2.5 3 23 46 66 44 66 0.98
3 12 3.7e-05 0.0034 19.2 3.7 1 23 72 94 72 94 0.97
4 12 0.00086 0.079 14.9 2.1 2 23 101 122 100 122 0.95
5 12 5.7e-05 0.0053 18.6 1.9 1 23 128 150 128 150 0.98
6 12 2.8e-05 0.0026 19.6 1.5 3 23 158 178 156 178 0.98
7 12 0.0006 0.056 15.3 2.6 1 23 184 206 184 206 0.98
8 12 0.0016 0.15 14.0 5.8 1 23 212 234 212 234 0.98
9 12 0.0003 0.028 16.3 4.2 1 23 240 262 240 262 0.98
10 12 0.029 2.6 10.1 3.5 3 23 270 290 268 290 0.96
11 12 0.00019 0.018 16.9 2.9 1 23 296 318 296 318 0.98
12 12 0.0037 0.34 12.9 0.3 3 23 322 342 320 342 0.97

Sequence Information

Coding Sequence
ATGAACAGTCTAACTAGTCTAAGAAATAACGGTTGTTCCAGATGCGAACTCAGATGCGCCGTTTGCGGTTCCGAGTTTCAACACTCGGCGAACTTGAAGCAGCACGTGTCGACGCACACTGAGAAGTCCTTCGGCTGCGACAtctgcgattacaagtgccgaaAATCGGCGGATCTGAAGCGGCACATGTTGAAACACACCCAGGAGAAGCCGCACGTTTGCGGCCTCTGCGACTACAAATGCCGATACGCCGAGAATTTGAAGCGGCACATGTTgacgcacaccgacgagaagccctTGAATTGCAcgctttgcgattacaagtgccgacAGTACGGCAGTTTGAAAAAGCACATACTagcgcacaccggcgagaagccctTCAGCTGCGAAGTTTGCGACTGCAAGTTCGAGGAGCAAGGAAAACTAAAGCGGCACATGTCGATACACACAGGCGAGAGACCGTACGGTTGTGAcctctgcgattataagtgccgacagCCCGGATATCTGCGGCGTCACATGCTGACGCACACCGACGACAAGCCATTCAgctgtgacctttgcgattataaatgtcgatacCCCGAGAGTATGAAACGGCACGTGTTAACGCACACGGgggagaagccgttcagttgtgaccacTGCGAGTATAAATGCGTACAATCGACGTATTTGAAGCAGCACCTGCTAACACACTTCGACGacaagccgttcagttgcgatctttgcgactaCAAGTGCCGAAAATCGGCGTACCTTAAGCAGCACATGCTGaaacataccggcgagaagccgttcggctGTGAgttttgcgattataaatgtcggcaACTCACGAGCTTGAAACAGCACACGCTGCAACACACCGGCGAAAAACCTTTCACTTGcaacctttgcgattacaaatgccggcAGCCCGGAAGGTTGAAGGAACACATGTTGAAGCACACCTTCGGTTGTGATAGTTGCGACTTGAAATTTCGAGAGGATGAGGAGTTGAAACGACACGTGTTAACACACACTGAAGAGAAGTCAAGCATTTAA
Protein Sequence
MNSLTSLRNNGCSRCELRCAVCGSEFQHSANLKQHVSTHTEKSFGCDICDYKCRKSADLKRHMLKHTQEKPHVCGLCDYKCRYAENLKRHMLTHTDEKPLNCTLCDYKCRQYGSLKKHILAHTGEKPFSCEVCDCKFEEQGKLKRHMSIHTGERPYGCDLCDYKCRQPGYLRRHMLTHTDDKPFSCDLCDYKCRYPESMKRHVLTHTGEKPFSCDHCEYKCVQSTYLKQHLLTHFDDKPFSCDLCDYKCRKSAYLKQHMLKHTGEKPFGCEFCDYKCRQLTSLKQHTLQHTGEKPFTCNLCDYKCRQPGRLKEHMLKHTFGCDSCDLKFREDEELKRHVLTHTEEKSSI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00465267;
90% Identity
iTF_00467111;
80% Identity
iTF_00467111;