Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 0.25 3.5e+02 2.9 0.4 15 44 26 55 24 63 0.88

2 10 0.68 9.5e+02 1.5 0.0 26 44 65 83 59 88 0.86

3 10 0.025 35 6.1 0.0 21 44 88 111 83 115 0.89

4 10 0.024 33 6.2 0.1 21 43 116 138 113 145 0.89

5 10 0.036 50 5.6 0.4 23 47 146 170 142 176 0.83

6 10 0.32 4.4e+02 2.6 0.1 21 43 172 194 169 199 0.88

7 10 0.0097 13 7.5 0.1 22 44 201 223 197 228 0.90

8 10 0.018 25 6.6 0.1 21 50 228 256 225 259 0.82

9 10 0.22 3.1e+02 3.1 0.0 21 44 256 279 253 283 0.89

10 10 0.0042 5.8 8.6 0.2 21 44 284 307 280 313 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	0.25	3.5e+02	2.9	0.4	15	44	26	55	24	63	0.88
2	10	0.68	9.5e+02	1.5	0.0	26	44	65	83	59	88	0.86
3	10	0.025	35	6.1	0.0	21	44	88	111	83	115	0.89
4	10	0.024	33	6.2	0.1	21	43	116	138	113	145	0.89
5	10	0.036	50	5.6	0.4	23	47	146	170	142	176	0.83
6	10	0.32	4.4e+02	2.6	0.1	21	43	172	194	169	199	0.88
7	10	0.0097	13	7.5	0.1	22	44	201	223	197	228	0.90
8	10	0.018	25	6.6	0.1	21	50	228	256	225	259	0.82
9	10	0.22	3.1e+02	3.1	0.0	21	44	256	279	253	283	0.89
10	10	0.0042	5.8	8.6	0.2	21	44	284	307	280	313	0.90

Coding Sequence: ATggataatttattaaacacCTGTTGTGACGCAGCAAACGACAACTGCGTAGTGGAATCGTGGTTCCAATGGATTCCTAAATCTCAATCGCCAAACAAAAGAACGATCGAGTGTCGCGTGTGCGGCACCAAACTTAAATCTCACAGAAGCATAAGCAAGCACATACTGATGCACGCCGACGAGAAGCTCCTCAGATGTGCCGTCTGCGATTACAGATTCAAGGACACCGGAAAGCTGCGACGGCACATGATGtcacacaccgacgagaagccgttcggctGCGAACACTGCGACTATAAATGCCGAGACTCCACGAAACTGAAACGGCACATGTTGATACACAGCGACGAGAAGCCGTACTTCTGCGGcctctgcgattacaaatgccgcaCCGCCAGGAATTTAAAACTGCACGAGTTCATCCACACCGGCGACATGCCGTTCAGTTGCCAGCTCTGCGAATACAAGTGCCGGGATTCCACGAGGTTGAGACAGCACATGCTGgtgcacaccggcgagaagccgtacagttgcgatctttgcgattacaagtgtcgGGGGCCCAGGGATCTGAAACTGCACAAGTTGGTACACACCGGTGAAATGCCGTTCGCTTGTgaactttgcgattacaaatgccgcgAGTCGACGAAGCTGAAACGGCACATGCTAACGCACACCGgggagaaaccgttcagttgcgacTATTGCGATTACAGGTGTTTAACATCGGCGAACTTGAAGCGGCACATGTTGACGCACACCGCCGAGAAACCGTACGGTTGTGAGCTTTGCGGTTGTAAATTCCGACAGCTCCCGCATTTGAAGGGGCACATGTTGACGCACACCGGAGAGAAACCCTTCAGCTGTGACCTTTGTGATTACAAGTGCCGACAGTCCGCTCATTTGAAGCAGCACATGTTGACACATCAACGGCGAGGAGCTCTTCAAATTTAG
Protein Sequence: MDNLLNTCCDAANDNCVVESWFQWIPKSQSPNKRTIECRVCGTKLKSHRSISKHILMHADEKLLRCAVCDYRFKDTGKLRRHMMSHTDEKPFGCEHCDYKCRDSTKLKRHMLIHSDEKPYFCGLCDYKCRTARNLKLHEFIHTGDMPFSCQLCEYKCRDSTRLRQHMLVHTGEKPYSCDLCDYKCRGPRDLKLHKLVHTGEMPFACELCDYKCRESTKLKRHMLTHTGEKPFSCDYCDYRCLTSANLKRHMLTHTAEKPYGCELCGCKFRQLPHLKGHMLTHTGEKPFSCDLCDYKCRQSAHLKQHMLTHQRRGALQI

Sequence clustering based on sequence similarity using MMseqs2