Basic Information

Gene Symbol
ZNF280A
Assembly
GCA_963691745.1
Location
OY829499.1:5242946-5248501[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.00066 0.042 15.0 0.3 1 23 219 242 219 242 0.92
2 10 0.0014 0.091 13.9 0.4 2 23 268 290 267 290 0.94
3 10 0.02 1.3 10.3 0.5 2 23 314 335 313 335 0.95
4 10 6.2e-05 0.0039 18.3 1.8 1 23 339 361 339 361 0.98
5 10 0.028 1.7 9.9 1.8 1 13 366 378 366 379 0.93
6 10 0.00011 0.0069 17.5 3.2 3 23 399 420 397 420 0.96
7 10 2e-06 0.00012 22.9 1.5 1 23 427 450 427 450 0.98
8 10 0.0018 0.11 13.6 0.3 1 23 456 478 456 478 0.96
9 10 2.3e-05 0.0015 19.6 2.3 1 23 484 506 484 506 0.98
10 10 1.3e-05 0.00079 20.4 1.3 1 23 512 535 512 535 0.97

Sequence Information

Coding Sequence
ATGGATGTGGTAAACTCGTGCCGGTGCTGCCTGCTGCGGCCACCGGACAAAAATCTGAAAACCCCGTATTCCCGTCTTGGCGAAACAGAAGTGTATTCGGACATGCTCAAAGAATGTTTCGAGATTCATGTGCAGGGCAACGAGGAGTGCGGCATCTGCGAGGTGTGCGTGTCGCGACTACGTGACGCCTGCGACTTTCGGCAGCAGGTGCAGCGCTGCCAGACCGAGCTGCTGCAGCTAGCGCGGGCGCTGCAAAGCAAAGGTGAGGAGGAAACGAAAGTGAAACTGGAACTATcagacgacgacgacgacaacGGAGCCTACATATTGCAACTGAAGGAGGAACTCTCGGACTACGAGGAGATGAAGCCGGGCGAGGACTCCAAGTTGGCCGCGATGCTGGGCTTCGAGCACGTCACCGTCAAGCGGCGCAGGCGCCGCTCGCGACTCGCCGCCGCCGACAGCGAGCGAAAATCACGAAAACTACTCACCCGGCCGGCGCTCGCCATATCGCTGCGTGCTCTCTCAAAGATAGACAAGATCCAAGCCCCCCTGCCGCGGTACGTCAGTGACAGCAGGAAGCACAAGCACAACATAGAAAACCTTCTCAAACACTGCAACGGGACCCCGTTCTCCAACAAaacactgtgcggttacatctGTGCGTACTGCAAGGAGACCTACACCGATCTGAAAGATCTAAGGACTCATACCGAAGCAGAACACAAAAACGCAGAGTTCTACGATACCAAGAGAAtggataaaaataatatgtcaGTTAAACTGGATATTACCGATTTGAAATGCACACTCTGCAACGAACGATTTGACGTTGTAGCTAATCTGAAGAAACATCTAGTTAAACAGCATGACATAAAATTCCATCCTGACGTTAAAGATTATATTATGGAGTTCAAATTGACCGATAACGAGATATTGAACTGTGCACTGTGCAATTCAACTTTCGAGACGTTTAAAATGTTATTGCAGCACATGAACGGGCATTACAGGAATTATATCTGCAACGTTTGCGATATGGGATTCATTAATAAGCATCGGTTGAAGAATCATGAACGAACGCATGACCTGGGCACTTACAAGTGTAGTTTCTGtgataaagtattcagcacccGTGTAAGGAAGATGTGTCACGAGAAGTACACACACAACAGCAGCGCTAGGTACACAACGAACTGTCCGCACTGTGACCAATCGTTCACGAGCTACTACCAACGTAACAGACACATGTTCACTGAGCACAACACGGTTGCTGCCTCATACAAATGCAATATATGTGACAAAAACTTCATTTTAAAGTCGAAGCTCACCTCACACATTAAGAAAGTTCACCTAATGGAACGGAACCACATCTGCCCGGAGTGCGGACAAGGGTTTTTTATCAAGCAATCATTAGATGAACATATGATCAAACACAACGGTGAACGAGTGCATAAGTGTAGTGTGTGTTTGAAAGCGTATGCCAGGAAGAAGACGTTGCGTGAACACATGAGAATCCACAACAATGACCGGAGGTTTAAATGTGGAGTCTGTGGACTCGCGTTTGTGCAGAAGTGCAGCTTGAAGAGTCATATGCTGTCGAATCATGGGATCACTCTCTCAGAGTTTGAGAGCAGGGAGCTGCACAGTCCGCAGACCTAG
Protein Sequence
MDVVNSCRCCLLRPPDKNLKTPYSRLGETEVYSDMLKECFEIHVQGNEECGICEVCVSRLRDACDFRQQVQRCQTELLQLARALQSKGEEETKVKLELSDDDDDNGAYILQLKEELSDYEEMKPGEDSKLAAMLGFEHVTVKRRRRRSRLAAADSERKSRKLLTRPALAISLRALSKIDKIQAPLPRYVSDSRKHKHNIENLLKHCNGTPFSNKTLCGYICAYCKETYTDLKDLRTHTEAEHKNAEFYDTKRMDKNNMSVKLDITDLKCTLCNERFDVVANLKKHLVKQHDIKFHPDVKDYIMEFKLTDNEILNCALCNSTFETFKMLLQHMNGHYRNYICNVCDMGFINKHRLKNHERTHDLGTYKCSFCDKVFSTRVRKMCHEKYTHNSSARYTTNCPHCDQSFTSYYQRNRHMFTEHNTVAASYKCNICDKNFILKSKLTSHIKKVHLMERNHICPECGQGFFIKQSLDEHMIKHNGERVHKCSVCLKAYARKKTLREHMRIHNNDRRFKCGVCGLAFVQKCSLKSHMLSNHGITLSEFESRELHSPQT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01072830;
90% Identity
-
80% Identity
-