Basic Information

Insect: Diorhabda carinata
Gene Symbol: MBD-R2_1
Assembly: GCA_029229535.1
Location: CM055255.1:8504124-8516784[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 2e-16 1e-12 47.9 0.1 8 74 428 493 424 496 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	2e-16	1e-12	47.9	0.1	8	74	428	493	424	496	0.92

Sequence Information

Coding Sequence: atgggACGCAAATGCAATGTGGAAAGTTGTCAATCTGATTCTAATCGCCCCCAAGATGTTGGAGTAACATTTCATAAAGTTCCTCCACATTTGGATATAAGACCCAAATGGTTATCGTTATGCAGAATTCCTGAAGATAAGAAATTTGTAAAAGTCCTTTATGTATGCTCCAGACATTTTTTACGAGCCGATTTCTGTAACTTTAAAGGTAAAAAATATATGCTGAAACAGGGTGTGCTACCAAGTGTGTTTCCATGGGACAAATCAAAATTGGAAGCTATTAAAGCTGAGGCAAAGAAAGAAAAACCGGTGCATATAAAGGAAGAACCTGTAGATGATAATACAGCTACACCAGATACTAAGCAAGAATTACCAAATGACTCAATTAAACAAGAAGTTCTTGATAgtgagaaaataaattcaagtagTAATGAGAAAAATGAACTGAAAGAAGACCCTGTAACAAGTACCAAATTAGTTCCATCAAATTCTACATCAATAAGCTTCTCAATAAATTCAAGAGTAGAAGCATTGGACTTTAACAATGAATGGTTTCCAGCTaagataattgaaattgattacGACGAAAATGAAGTGCTGATACATTTTGAGAATTATTCAAGTAAATATGATGAATGGATATCTATGGACAGCTCAAGACTGCGGCCCTTACAAAATGCAGATACAAAAACTGAAACCAGTAAAATTGATGATGCTATTGCTAATATTGATCCAAATCCAATAATACACAACGTGGATAAGAAACCAGCTGTAATGGAAACCTATGTTGTTGGGGAGAGATGTCTAGCCACATGGAGTAATTCTAGAAAATTTCCTGCGACAGTTACAAAGGTTTTGGAAAACAatTCATATGAAGTATTATTTGATGATGGGTTTGTTAAAACTGCTAAAGCTAAATCCATGAGTAAAACTCAAGGCAAACCGATTCAATCCAGTCCTCTTTTTGATCCGATCAAAAGTAGTAAACAGGATAGAagagagaaaaaaagaaaactgaatGTAGCTGCTTTATTTAGAAAAAGACCTAAACTAGAAACTTCACCAGATAAGGTTAAGAAAATACCAAGTAATACGGTAGCTAATGTACAATCTCCACTTCAAGCTCAAACAGAATCACCCATAGAGCAAGACATGCCAATAGTACAGCCCTCtccaattgatattgaaaactGGAAGCCAAGTTGGTACAAAGGGAAACCAGTTGGAATAGAATCCACACTACACACTCAAGATGGTCCAAAAGTGTCTTATATTGTCCCAGATCCACGGATTCCGCCAGGTTGGAATAAACATATATTAAGGAGAACAAAGGGTTGTGATGCTGGTAAATGGGATACAATTATTGTTAGTCCAGAAAACAAAAGATTTAGATCAAAGACAGAAATTCTTAGATATATAGAGGAGCATCCAAATgagaatttgaatgaaaaaatgttcgatttttcatttgttatgaGAAGAAAACGGAAAAATCCAGCTCTAACAACTCCAACAAAATCTCCTGAAAAGGAAAAACCCCCACCTTTGATTACACCCGAAGAACCAGTTGAACAACCTGAAGTTAAAAACGATAAAGAAGAGAAAGATGATGaaGATTCAAATGGACTGAAAATACTGTTTGAAGATGATGCTTACAAATGTCCAATAGAGGGATGCGGAAAAAATTTCAGGAGAGAAAATTTAGCTCAAATGCATGTGAAACACTACCATCCAGAATATACCAAATTCCTGGATTCAACTCCAAACGTTGCTGATTTGGCATATGCACGAACAGTTGGGGAAAATCTTGACAGATCCCCAGGACCTCAGAAACCACCTTTTAAAACAGCACCAAAGTTTCTAACTCCCAAAACTTCCAAGCACTCAGCTTCAGATCTAGAAGATATGCCTGAATTGAAACctgaaataaaaccaaaatcgATTCCGGTTTCTAAGTCCAAAGATCAGGAAATTATAAAACTGTTAAATGCCAAACCCTATAATAAGCAAGAAGAAAGTAATACGCAACAACAAAATTTGGGAAATGTTAGTCTTCTAAACACTGACATAAAACACAAAGATTCATCAACAAAGAGTGATAGTGTCCCAAAGAGGGAAATACCAacattaaaaactttattaaagaACAGGACTTTTACTGGCATCAAGACTTTGCTACCTGTTCATCGCACTAAAACAGATAATTCTCCAGCTGAAAAATCAATTGAGGAACACTACAAACCACCATCAAAGCGAAAGTCGGCGTTTGCAGATACTATAGAGATAATAAAAGGTacagaaaaaactgaaacacCACCTTTACTTCATCCTATTTCCACACCTACAcctacaaaaattaaaattccatCATCACCACCAACACACCAACAACCGCTACAACAAACACTATCATCCTCTTTAACATTAGATCCTCCTATTCTCACTCCTCAAATAGAATCATCACCTTCTTCCAATCCTAATCCTCcctttaataatataataattgaaggCGGAGAAGTTATCAAGATTGTCAGGATGAAACAAGAAGAAATCATCAACTGTACATGTGGATTTACAGAAGAAGATGGTCTGATGATACAATGTGAACTATGTCTTTGTTGGCAACATGCATATTGTAACAACATTGAAAGAGAAAGTCAAGTTCCTGAAAAGTATGTTTGTTATATTTGTCAAAATCCATTTAGAGAAAGATTATCCAGGAAGTATTATCACGATCAAGATTGGTTGACAAAAGGAGTATTGCCTGTAGGAAGTTACCATACTAGAGATGATGATGCATTACAGAAGAGGTTCGATAGATTGAAAAAATGTCACGATTTATCAGGAGGTTTGATGGAACTTGGACATTATCAacatagtttgaaaataaaaatgaagatagCTGaAGCAAAGAACCATCCAAAATTGTATTTATGGTCGAAACCTTGgtctaaaaaatgtttaccTGAGAAAGCAAAACCAGAACTTGAAGATGCTAAACCAAAAGTAGAAAGTGAAGTAACAGAATTTCTTAAGAATGACTTTGATGTTGAGAAAGAATCCCAAAATGAGAATTCAATGTTGATGATGTTATTGAAAGACGGTAAAAATGTAATGTCAAAACTTGATTTGAATACATTAATGGACAATACTCCAATAATACCTCAACCGGAAGCTATTGTAGATTCTGCAGACTGTCGATTGAATTTACTTGAACACCTGGTTCACGAATATTCTCTGGTAGAAGAAAGATTGGACAGTTTCGAGAGACAGCTCAGTATGTTAGAAGAAACAGTTAATGTAGAAAGAGATATTGAATATCCAAAAACAAGAAATACAATGCAGATGCTGATGAGGGATTTAGAAACATTGAAAGAATTTAGTCACAGTTCTGTGTTATGA
Protein Sequence: MGRKCNVESCQSDSNRPQDVGVTFHKVPPHLDIRPKWLSLCRIPEDKKFVKVLYVCSRHFLRADFCNFKGKKYMLKQGVLPSVFPWDKSKLEAIKAEAKKEKPVHIKEEPVDDNTATPDTKQELPNDSIKQEVLDSEKINSSSNEKNELKEDPVTSTKLVPSNSTSISFSINSRVEALDFNNEWFPAKIIEIDYDENEVLIHFENYSSKYDEWISMDSSRLRPLQNADTKTETSKIDDAIANIDPNPIIHNVDKKPAVMETYVVGERCLATWSNSRKFPATVTKVLENNSYEVLFDDGFVKTAKAKSMSKTQGKPIQSSPLFDPIKSSKQDRREKKRKLNVAALFRKRPKLETSPDKVKKIPSNTVANVQSPLQAQTESPIEQDMPIVQPSPIDIENWKPSWYKGKPVGIESTLHTQDGPKVSYIVPDPRIPPGWNKHILRRTKGCDAGKWDTIIVSPENKRFRSKTEILRYIEEHPNENLNEKMFDFSFVMRRKRKNPALTTPTKSPEKEKPPPLITPEEPVEQPEVKNDKEEKDDEDSNGLKILFEDDAYKCPIEGCGKNFRRENLAQMHVKHYHPEYTKFLDSTPNVADLAYARTVGENLDRSPGPQKPPFKTAPKFLTPKTSKHSASDLEDMPELKPEIKPKSIPVSKSKDQEIIKLLNAKPYNKQEESNTQQQNLGNVSLLNTDIKHKDSSTKSDSVPKREIPTLKTLLKNRTFTGIKTLLPVHRTKTDNSPAEKSIEEHYKPPSKRKSAFADTIEIIKGTEKTETPPLLHPISTPTPTKIKIPSSPPTHQQPLQQTLSSSLTLDPPILTPQIESSPSSNPNPPFNNIIIEGGEVIKIVRMKQEEIINCTCGFTEEDGLMIQCELCLCWQHAYCNNIERESQVPEKYVCYICQNPFRERLSRKYYHDQDWLTKGVLPVGSYHTRDDDALQKRFDRLKKCHDLSGGLMELGHYQHSLKIKMKIAEAKNHPKLYLWSKPWSKKCLPEKAKPELEDAKPKVESEVTEFLKNDFDVEKESQNENSMLMMLLKDGKNVMSKLDLNTLMDNTPIIPQPEAIVDSADCRLNLLEHLVHEYSLVEERLDSFERQLSMLEETVNVERDIEYPKTRNTMQMLMRDLETLKEFSHSSVL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00458998;
90% Identity: iTF_00458998;
80% Identity: iTF_00458998;