Basic Information

Insect: Dinoponera quadriceps
Gene Symbol: gsb
Assembly: GCA_001313825.1
Location: NW:178366-200841[+]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 2.3e-73 3.3e-70 233.0 1.0 1 125 19 144 19 144 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	2.3e-73	3.3e-70	233.0	1.0	1	125	19	144	19	144	0.98

Sequence Information

Coding Sequence: ATGGCAGTCAGCACTCTCAATATGGCACCCTACTTCACTGGATACCCTTTCCAAGGACAGGGTCGCGTGAACCAGCTGGGCGGTGTGTTCATCAACGGCCGTCCGTTACCGAACCATATCCGATTGAAGATCGTCGAAATGGCAGCGGCCGGTATCAGGCCGTGCGTCATCTCCAGACAACTGAGAGTCTCTCACGGCTGCGTCTCGAAGATCTTGAATCGGTATCAGGAAACGGGATCGATCAGACCCGGTGTGATCGGTGGTAGCAAACCGCGAGTCGCGACGCCGGAGGTCGAGGCGAGGATCGAGGATCTCAAGCGGCAAAACCCGGGAATCTTTAGCTGGGAGATACGCGACAAATTAATCAAGCAGGACGGAGTTTGCGACAAAGCTTCGGCACCGTCGGTGTCGAGCATCTCCAGACTCCTACGCGGACCGACCAATCAGACTCGTCCTGACGACCCGCGCCGGAACCACTCCATCGATGGGATCCTCGCTGGAAGTAGCGGCGATGACTCCGACACGGAAAGCGAGCCAGGTATCGCGCTCAAAAGGAAACAACGAAGGAGTAGGACTACCTTTACCGGCGAGCAACTGGAGCAACTGGAAGCGGCTTTTCATCGCACGCAATATCCCGATGTATACACGAGGGAGGAACTCGCGCAAAAAACGAAATTGACGGAAGCACGAGTGCAGGTCTGGTTCAGCAACAGGCGCGCCAGGCTTCGTAAACAGCTCAACAGTCAACAGCTGAACGCCTTCAACACTATGAGTCTACAGTCTTTCCAGACCCAGCACTATGGCAGCGGTGCTGAGAGCTATCAGAGCTACGGACAGGCGAGCGTTGCTGCCGCCGCAGCAACCACTGCCGGTTATTCCCAACATTACAACTATGGGGAGAACTATTATGCGGCGCAGCAACAATGGCCACGGGCGACTCCGGAAAATTATGGATTGTTCAACGCCTCCCATTACGGCAGCGGCAACCTTGCCTCCAACCTGACTTCCAGCAATCTCAATCTGGGCAGTCTGGGTGGCAGCGTAAGCCCGACCGCGTCTAACATGAGCGCCTGCATGGTGCAAAGCGCATCCTCTTCCGGGGTGCCAGCCCCGACGGGAATGACGCACCACGTGACACCTCACAGCCCCAGCGAGGCTAAGAGCGGATATCCGTACTTGGGTGGCATTGATTCCCAGGTTTGCGGAAGAGTCCACTGA
Protein Sequence: MAVSTLNMAPYFTGYPFQGQGRVNQLGGVFINGRPLPNHIRLKIVEMAAAGIRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPRVATPEVEARIEDLKRQNPGIFSWEIRDKLIKQDGVCDKASAPSVSSISRLLRGPTNQTRPDDPRRNHSIDGILAGSSGDDSDTESEPGIALKRKQRRSRTTFTGEQLEQLEAAFHRTQYPDVYTREELAQKTKLTEARVQVWFSNRRARLRKQLNSQQLNAFNTMSLQSFQTQHYGSGAESYQSYGQASVAAAAATTAGYSQHYNYGENYYAAQQQWPRATPENYGLFNASHYGSGNLASNLTSSNLNLGSLGGSVSPTASNMSACMVQSASSSGVPAPTGMTHHVTPHSPSEAKSGYPYLGGIDSQVCGRVH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00718374;
90% Identity: iTF_00452427; iTF_00231265; iTF_00684001; iTF_00982913; iTF_00140419; iTF_00228611; iTF_01417539; iTF_00141094; iTF_00215654; iTF_00227110; iTF_00760934; iTF_00227911; iTF_00229863; iTF_00222472; iTF_00214857; iTF_00216905; iTF_01122377; iTF_00223818; iTF_00233066; iTF_00982123; iTF_01424203; iTF_00117836; iTF_00142316; iTF_00675852; iTF_00218253; iTF_00226541; iTF_00963021; iTF_00220526; iTF_00982798; iTF_01417646; iTF_01539438; iTF_00140528; iTF_00142416; iTF_00223024; iTF_00227792; iTF_00231152; iTF_00684113; iTF_00228499; iTF_00963700; iTF_00215541; iTF_00229973; iTF_00233173; iTF_00227222; iTF_00733814; iTF_00963798; iTF_00214967; iTF_00733911; iTF_01424311; iTF_00760824; iTF_00218361; iTF_00117947; iTF_00217019; iTF_00223707; iTF_00226427; iTF_00982235; iTF_01122268; iTF_00963133; iTF_01539549; iTF_00220414; iTF_00223134; iTF_00675966; iTF_00141183; iTF_00222367; iTF_00460321; iTF_01394246; iTF_01391912; iTF_01391052; iTF_01394125; iTF_00460463; iTF_01390160; iTF_01391792; iTF_01390930; iTF_01393464; iTF_01390043; iTF_01393340; iTF_01419585; iTF_01419481; iTF_01420221; iTF_01420126; iTF_00769571; iTF_01087146; iTF_01087055; iTF_00769470; iTF_00898694; iTF_00898598; iTF_01066887; iTF_01070310; iTF_01067559; iTF_01069607; iTF_01068809; iTF_01065386; iTF_01065514; iTF_01069484; iTF_01070191; iTF_01068242; iTF_01067444; iTF_01068118; iTF_01068920; iTF_01066076; iTF_01066204; iTF_01066781; iTF_00867341; iTF_00867233; iTF_00264110; iTF_00264848; iTF_00264945; iTF_00264214; iTF_00010927; iTF_00011041; iTF_00729999; iTF_00729900; iTF_00754417; iTF_00754574; iTF_00128146; iTF_00128019; iTF_00128919; iTF_00128798; iTF_00084499; iTF_00084360; iTF_00730679; iTF_00730572; iTF_00129563; iTF_00129687; iTF_00360156; iTF_00360050; iTF_01120156; iTF_01120060; iTF_01389373; iTF_01389264; iTF_00302976; iTF_00302870; iTF_01077312; iTF_01077410; iTF_01420768; iTF_01420878; iTF_00221093; iTF_01123010; iTF_01122917; iTF_00216329; iTF_00221205; iTF_00216223; iTF_00221763; iTF_00221860; iTF_00232452; iTF_00214341; iTF_00232553; iTF_00231828; iTF_00231930; iTF_00214239; iTF_00230640; iTF_00230541; iTF_00773755; iTF_00773627; iTF_00109766; iTF_00109666; iTF_00126535; iTF_00127399; iTF_00127281; iTF_00126656; iTF_00224394; iTF_00224496; iTF_00219633; iTF_00225076; iTF_00225180; iTF_00219742; iTF_00385260; iTF_01015756; iTF_00385115; iTF_01015646; iTF_00181251; iTF_00181158; iTF_00884902; iTF_00181816; iTF_00885048; iTF_00181916; iTF_01261699; iTF_00014567; iTF_00014668; iTF_01261786; iTF_01476867; iTF_01476771; iTF_01523208; iTF_01523306; iTF_00015321; iTF_01476026; iTF_01476122; iTF_00015229; iTF_01422761; iTF_01422869; iTF_01422074; iTF_01422173; iTF_01477514; iTF_01477415; iTF_01405523; iTF_01405637; iTF_01409046; iTF_01408899; iTF_00417399; iTF_00417505; iTF_00016536; iTF_00016629; iTF_01355257; iTF_01355150; iTF_01407067; iTF_01407216; iTF_01407997; iTF_01408138; iTF_01266829; iTF_01267393; iTF_01270350; iTF_01266738; iTF_01270451; iTF_01267508; iTF_01268860; iTF_01268989; iTF_01268112; iTF_01268219; iTF_01269744; iTF_01269640; iTF_00229295; iTF_00229190; iTF_01520175; iTF_01520068; iTF_01537679; iTF_01537891; iTF_00125744; iTF_00125867; iTF_00225745; iTF_00225858; iTF_00756471; iTF_00756583; iTF_00964313; iTF_00964429; iTF_01418842; iTF_01418947; iTF_00217694; iTF_00217589; iTF_00306207; iTF_00306089; iTF_01498143; iTF_01498036; iTF_00292224; iTF_00292125; iTF_00293665; iTF_00296610; iTF_01475394; iTF_00770211; iTF_01473124; iTF_00295845; iTF_00253510; iTF_00295078; iTF_01474630; iTF_00254919; iTF_00297383; iTF_01130759; iTF_01198503; iTF_01199241; iTF_01473867; iTF_00298252; iTF_00252653; iTF_00254157; iTF_00291373; iTF_00252015; iTF_00770320; iTF_00296721; iTF_00255027; iTF_00293555; iTF_01198613; iTF_01394965; iTF_00295191; iTF_00295959; iTF_00297496; iTF_01130648; iTF_01475288; iTF_00291481; iTF_01199353; iTF_01473017; iTF_00252763; iTF_01474523; iTF_00253404; iTF_00254269; iTF_01473757; iTF_01395070; iTF_00251903; iTF_00298144; iTF_01099136; iTF_01099035;
80% Identity: iTF_00452427;