Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 2.2 6.8e+02 0.9 0.1 85 104 30 49 24 54 0.83

2 3 3.1e-22 9.8e-20 71.2 0.0 6 106 122 224 119 228 0.91

3 3 0.21 67 4.1 0.0 79 109 229 259 219 260 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	2.2	6.8e+02	0.9	0.1	85	104	30	49	24	54	0.83
2	3	3.1e-22	9.8e-20	71.2	0.0	6	106	122	224	119	228	0.91
3	3	0.21	67	4.1	0.0	79	109	229	259	219	260	0.85

Coding Sequence: ATGTATCATAGTGCAGAAAATAATCATTTAGACATAACAATTGAATTACGTGCATTAGGCGTACCATGGACATTACATTGTTGGATGCATGCATTGGCTGCCGCCCATGAATTACGTTTAGATGCGGTCATTGATCAATTATTACAAGATTTTTTACAAGTTTGTCCCGATGATTATAGTTCACAATTTGTAACCGAATGTCttccattattatttaatatatttcgtTATAGTAAAaaagaaggaacaacattattattagCCGATATATTTGCAACGTGTTTTAGTTGGGAACCAATTAAACCAATAAAAGAACCAGTATTACAATCAAATAATAGTTCACGTATTGATCCGAAATTTGTGAATAATCCGGAATTAAGTGATGTTATGTTTAGaGTTGaaggtaaaatattttatggacATAAAATAGTATTAGTAACGGCATCACCACGTTTTCAAAGTATGTTAAGTTCAAAGTTAAGTGGTGAAGGTAATACACCAACCGTACAAATTAATGATATACGTTATCAAATATTTCAGTTGGTTATGCAATTTTTATACAGCGGTGGTTGTAATTCATTAGATGTGGTGGCCGGTGATGTCTTGGAATTGATGGCAGCTGCAAGTTTTTTTCAATTAGATGGTTTGGTTCGGTATACCGAGGCACGTTGTTCACAAATGattgatattgataatgtTGTTGCAATGTACATACACGCAAAGGTTTATAATGCACCAAAACTTATGGAATATTGTCAAGGATTTCTATTACAACATATGGTTGCTCTATTAACGTATGACGATTCTGTTAAACGATTATTATTTGCTAAGAAAATTCCAAATCATGATGTTTTATCGGGTCTATTGGCAACCTTACAAATTCGTATTAAAACTAGAAgacagcagcaacaacaacaacaaactaCATCTTCTGTACAATCACCACAACCACAACATCCATCAAATATTGTAAGATCATCGACTGCTGTAGTTGTAgctaataaaatacaaaaataa
Protein Sequence: MYHSAENNHLDITIELRALGVPWTLHCWMHALAAAHELRLDAVIDQLLQDFLQVCPDDYSSQFVTECLPLLFNIFRYSKKEGTTLLLADIFATCFSWEPIKPIKEPVLQSNNSSRIDPKFVNNPELSDVMFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSGEGNTPTVQINDIRYQIFQLVMQFLYSGGCNSLDVVAGDVLELMAAASFFQLDGLVRYTEARCSQMIDIDNVVAMYIHAKVYNAPKLMEYCQGFLLQHMVALLTYDDSVKRLLFAKKIPNHDVLSGLLATLQIRIKTRRQQQQQQQTTSSVQSPQPQHPSNIVRSSTAVVVANKIQK

Sequence clustering based on sequence similarity using MMseqs2