Dcae021118.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Diloba caeruleocephala
Gene Symbol
foxn3
Assembly
GCA_947459985.1
Location
OX381619.1:7535618-7555983[+]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.6e-35 2e-32 111.7 0.0 2 85 161 242 160 245 0.95

Sequence Information

Coding Sequence
ATGGCGCCAATGCGCGGCGAGCGGGGTGGTTCCCCAGCGCGAGGCGCGCGCGCATCTCTGCCACTTCCGCGACGGTTGATTCGCCAGATCGCACGTCACGTCGCCTCCAGCGGCCGCTCACTACGCCGATTAGAGGTGTCAGGCAGGGTCATTGACAACTTCGATGACATTGAGGATGCGTCTGACGAATCCGATATGGAACAGCCACAACCTGCGGTGGCTTGCGGAGGCAACGCCGGCAACCTGCCCCCGGCCGACCACGACGATGACCTCACCAGTTTGAGCTGGCTGCAAGACAGAAATTTACTAAGAGGTATAAATCTTACAAAAAGCGGAGTCGATATGGAAGACACGAAAATGGTTGACAACCAAATCATTTTAAAGAGAGAAACAAAAACCCCACCACCAGTGGCGAGAGTACCCTCCCCACCCCGTACACCATGCAAGGCCCCTCCATCACCTCCAGCCAACACCCATACGAAGCCACCATATTCCTTCTCGTGCCTCATCTTCATGGCCATCGAAGCGGCCCCTGCGAGAGCCCTGCCCGTTAAGGAGATCTACGCGTGGATCATACGCCACTTCCCGTACTTCAGACACGCACCCCAAGGCTGGAAGAATAGTGTTAGGCATAATCTGTCCTTAAACAAGTGCTTCCATAAGGTGGCGGCTGCACCGGGTCTTGGTAAAGGTTCACTTTGGACTGTCGACCCGCAGCATCGCGCTTCATTGTTACAGGCGTTCGGCCGACAGCCGATCCCCGCGGCGGGGGAGGCGGGTGAGGGGGGCGAGGGCGGCGAGGCTCGGGTGTCGCTGCTGGCGCGGCGCTTGGCCGAGCCCGAGCCCGGCGCCGACGAGTACCTGGCCGCCGCCACCGTGCTCGCCATGAAGTACGGGCCCGCCGTGCTCGACCAGTTGCCGCCAGCGGCCCACCTGGTGATCTCCCGCTGCGCACGCGACGAGCACTCGTACAGCGGCGGCGAGGAGCGGCGCACGGCCGAGGCGCTGCTCAACCTGGCGGGCGTGCGCTCCGAGCCCGCGCCCAGCTAG
Protein Sequence
MAPMRGERGGSPARGARASLPLPRRLIRQIARHVASSGRSLRRLEVSGRVIDNFDDIEDASDESDMEQPQPAVACGGNAGNLPPADHDDDLTSLSWLQDRNLLRGINLTKSGVDMEDTKMVDNQIILKRETKTPPPVARVPSPPRTPCKAPPSPPANTHTKPPYSFSCLIFMAIEAAPARALPVKEIYAWIIRHFPYFRHAPQGWKNSVRHNLSLNKCFHKVAAAPGLGKGSLWTVDPQHRASLLQAFGRQPIPAAGEAGEGGEGGEARVSLLARRLAEPEPGADEYLAAATVLAMKYGPAVLDQLPPAAHLVISRCARDEHSYSGGEERRTAEALLNLAGVRSEPAPS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01377288;
90% Identity
iTF_00040611; iTF_00043301; iTF_00042449; iTF_00039612; iTF_00041596; iTF_01064451; iTF_00667172; iTF_01285364; iTF_00757957; iTF_01030951; iTF_00185128; iTF_01439713; iTF_00038514; iTF_01526835; iTF_00036441; iTF_00072066; iTF_00745444; iTF_00622629; iTF_00071221; iTF_01525750; iTF_00122174; iTF_00121215; iTF_00363845; iTF_00448838; iTF_01440806; iTF_00830984; iTF_01025801; iTF_00905931; iTF_00907697; iTF_00124055; iTF_00906878; iTF_01487533; iTF_00637294; iTF_01166413; iTF_01027118; iTF_01092884; iTF_01094716; iTF_01093856; iTF_00809877; iTF_00273430; iTF_00726103; iTF_00924407; iTF_01029975; iTF_00326904; iTF_01192441; iTF_01230329; iTF_00037594; iTF_00808922; iTF_00274265; iTF_01084956; iTF_01084067; iTF_01532846; iTF_00711632; iTF_01534613; iTF_01533751; iTF_00300987; iTF_00301918; iTF_00685248; iTF_01538557; iTF_00123167; iTF_00373728; iTF_00952520; iTF_00951612; iTF_00851536; iTF_00973538; iTF_00850412; iTF_00771693; iTF_00299968; iTF_00017162; iTF_00017997; iTF_00383439; iTF_00171576; iTF_01424864; iTF_01029034; iTF_01332363; iTF_00147118; iTF_01063567; iTF_01061698; iTF_01062571; iTF_01028080; iTF_00888034; iTF_00784211; iTF_00783245; iTF_01246644; iTF_00120307; iTF_00280949; iTF_00282085; iTF_00677358; iTF_01221311; iTF_00049718; iTF_00785020; iTF_00785833; iTF_00446934; iTF_01342038; iTF_01361398; iTF_01259896; iTF_00928476; iTF_00176925; iTF_00404511; iTF_01491696; iTF_00908631; iTF_00794138; iTF_00869440; iTF_00444927; iTF_00445926; iTF_01362911;
80% Identity
-