Dcae005686.1
Basic Information
- Insect
- Diloba caeruleocephala
- Gene Symbol
- lz
- Assembly
- GCA_947459985.1
- Location
- OX381620.1:16520263-16540657[-]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 1.2e-74 6.5e-71 236.5 0.0 3 129 50 176 48 176 0.98
Sequence Information
- Coding Sequence
- ATGTGTAGCACGCAGCGAGCGCGGGTGTCGAGGATGCACTTGACGGGCGCGAATAGCGGCGCCGTGTCGCCCGACACCAGCTCCACGCTGCTACATGAAACGTACACGAAGATGACATCCGACATCCTCGCCGAGCGAACGCTTGGTGACTTTTTGTCTGAACACCCTGGAGAGTTGGTCAGGACGGGTAGCCCTCACTTCGTGTGTACGGTGTTGCCTCCTCACTGGAGATCGAACAAAACTTTGCCGGTGGCGTTCAAAGTGGTAGCTCTAGGTGACGTGGGTGATGGCACGATGGTAACGGTGAGAGCTGGCAACGACGAAAACTGCTGCGCAGAGCTGAGGAACAGTTCTGCGGTGATGAAGAACCAGGTCGCAAAGTTCAACGACTTAAGATTCGTCGGCCGCAGTGGTCGCGGTAAATCGTTTACGTTAACGATAACTGTGTCAACGACGCCGCCGCAGGTGACCACGTACAACAAAGCTATCAAGGTGACGGTGGACGGACCGAGGGAACCTCGCTCCAAGACCAGTTAG
- Protein Sequence
- MCSTQRARVSRMHLTGANSGAVSPDTSSTLLHETYTKMTSDILAERTLGDFLSEHPGELVRTGSPHFVCTVLPPHWRSNKTLPVAFKVVALGDVGDGTMVTVRAGNDENCCAELRNSSAVMKNQVAKFNDLRFVGRSGRGKSFTLTITVSTTPPQVTTYNKAIKVTVDGPREPRSKTS
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00032679;
- 90% Identity
- iTF_00621794; iTF_00771650; iTF_01316100; iTF_00642117; iTF_01534565; iTF_01077959; iTF_00985768; iTF_00772653; iTF_01084910; iTF_01415598; iTF_00072047; iTF_01264175; iTF_00821552; iTF_00858320; iTF_00951568; iTF_00364690; iTF_00874226; iTF_01025746; iTF_01339732; iTF_00875926; iTF_01173048; iTF_00288633; iTF_00063356; iTF_00287837; iTF_01360381; iTF_01435837; iTF_01317054; iTF_00374943; iTF_01090463; iTF_01082211; iTF_00840103; iTF_00275021; iTF_01033497; iTF_01017509; iTF_01129831; iTF_00445885; iTF_00971007; iTF_00255588; iTF_00032679; iTF_00273384; iTF_00194953; iTF_00361386; iTF_00408171; iTF_00808875; iTF_00041552; iTF_00142868; iTF_01061653; iTF_01143637; iTF_00000090; iTF_00113908; iTF_01494837; iTF_00844090; iTF_00647772; iTF_00112286; iTF_01062526; iTF_00467967; iTF_00421123;
- 80% Identity
- -