Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 1e-09 3.2e-06 28.2 6.2 1 38 59 96 59 101 0.91

2 4 0.16 5.3e+02 1.9 1.3 3 13 200 210 165 216 0.73

3 4 0.12 3.8e+02 2.4 0.5 3 15 200 212 198 223 0.72

4 4 4.5 1.5e+04 -2.7 0.0 12 27 250 265 247 272 0.75

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	1e-09	3.2e-06	28.2	6.2	1	38	59	96	59	101	0.91
2	4	0.16	5.3e+02	1.9	1.3	3	13	200	210	165	216	0.73
3	4	0.12	3.8e+02	2.4	0.5	3	15	200	212	198	223	0.72
4	4	4.5	1.5e+04	-2.7	0.0	12	27	250	265	247	272	0.75

Coding Sequence: ATGGCACACGCACCCTTATATCCCAAGTCCCAAGAACCACTGAATCAAATGCCCCAAATGTCCCAAGTGCCGCTGAATCAAACCCAACAAATGTCCCAAGTGCCTCAGAATCATTTGCCCCTAATGTCCCAAGTACCCCAAAATCAAATGCCCTCGGCTCAAGCAGCCTTCGGTCCCGAGCCATGCACGGTGACCTGTCCATCTTGCGGCAAGTCCATCGTCACCCATGTTATGATGAAATCTACCACGCAGACCCATCTAGTGGCGTTGCTCTTATGTTGTTTATGGGTCAACTATACGCAGAAGACAATCAACGCCCTGCGCATACAGTATAACAATGCCTTTAGGATGCTGATGCGGCTGCCGAGGTACTGCAGCGCGTCAGGCATGTTTGCCGACGCTCGCATTGATGGCTTTCATGCCATCCTCAGAAAGAGAGCTGCATCATTGCTTAGTCGTGTCCGCGGCAGTGGCAATGGCATTCTCAGCGTTGTGGCTGGCAACATCGACTGTCCAGTATTGTGGCACTGTGTGCAGTTACATGTCGTTACAAAAAATTGTCTTGGAATAACTATAGATCAAGTCAATGAAGACGAAAAAAGTCAGTGGATATGTCCAGAGTGCCGTGCTTCTACGCATAAAACTCTGTGCAACGAGAATACACCTGCTCGAAGAGTGTCAGGGCTGGGGGACACCTTTACTGCTAGCAACTATGTCAATACACAGCGCGGCAGTCGTCCGAAAATATCTGAAGAAACTGTGACGAAGACGGCTCAGGAGCCTAATATGTTGGAAGAACTGGGAGCATTCCGCTTGGAAGTTGTATCACACTTAGAAATCCAAGAAAACAACATTAAAAGGATCGAAGAAGTCTGTTAG
Protein Sequence: MAHAPLYPKSQEPLNQMPQMSQVPLNQTQQMSQVPQNHLPLMSQVPQNQMPSAQAAFGPEPCTVTCPSCGKSIVTHVMMKSTTQTHLVALLLCCLWVNYTQKTINALRIQYNNAFRMLMRLPRYCSASGMFADARIDGFHAILRKRAASLLSRVRGSGNGILSVVAGNIDCPVLWHCVQLHVVTKNCLGITIDQVNEDEKSQWICPECRASTHKTLCNENTPARRVSGLGDTFTASNYVNTQRGSRPKISEETVTKTAQEPNMLEELGAFRLEVVSHLEIQENNIKRIEEVC

Sequence clustering based on sequence similarity using MMseqs2