Basic Information

Insect: Diarsia mendica
Gene Symbol: -
Assembly: GCA_949316265.1
Location: OX438892.1:401532-410411[-]

Transcription Factor Domain

TF Family: Homeobox
Domain: Homeobox
PFAM: PF00046
TF Group: Helix-turn-helix
Description: This entry represents the homeodomain (HD), a protein domain of approximately 60 residues that usually binds DNA. It is encoded by the homeobox sequence [7, 6, 8], which was first identified in a number of Drosophila homeotic and segmentation proteins, but is now known to be well-conserved in many other animals, including vertebrates [1, 2], as well as plants [4], fungi [5] and some species of lower eukaryotes. Many members of this group are transcriptional regulators, some of which operate differential genetic programs along the anterior-posterior axis of animal bodies [3]. This domain folds into a globular structure with three α-helices connected by two short loops that harbour a hydrophobic core. The second and third form a helix-turn-helix (HTH) motif, which make intimate contacts with the DNA: while the first helix of this motif helps to stabilise the structure, the second helix binds to DNA via a number of hydrogen bonds and hydrophobic interactions, which occur between specific side chains and the exposed bases and thymine methyl groups within the major groove of the DNA. One particularity of the HTH motif in some of these proteins arises from the stereo-chemical requirement for glycine in the turn which is needed to avoid steric interference of the β-carbon with the main chain: for cro and repressor proteins the glycine appears to be mandatory, while for many of the homeotic and other DNA-binding proteins the requirement is relaxed.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 13 1 5e+02 2.2 0.0 42 51 74 83 62 86 0.86

2 13 1 5e+02 2.2 0.0 42 51 157 166 145 169 0.86

3 13 1 5e+02 2.2 0.0 42 51 240 249 228 252 0.86

4 13 1 5e+02 2.2 0.0 42 51 323 332 311 335 0.86

5 13 1 5e+02 2.2 0.0 42 51 406 415 394 418 0.86

6 13 1 5e+02 2.2 0.0 42 51 489 498 477 501 0.86

7 13 1 5e+02 2.2 0.0 42 51 572 581 560 584 0.86

8 13 1 5e+02 2.2 0.0 42 51 655 664 643 667 0.86

9 13 1 5e+02 2.2 0.0 42 51 738 747 726 750 0.86

10 13 1 5e+02 2.2 0.0 42 51 821 830 809 833 0.86

11 13 1 5e+02 2.2 0.0 42 51 904 913 892 916 0.86

12 13 1 5e+02 2.2 0.0 42 51 987 996 975 999 0.86

13 13 1 5e+02 2.2 0.0 42 51 1070 1079 1058 1082 0.86

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	13	1	5e+02	2.2	42	51	74	83	62	86	0.86
2	13	1	5e+02	2.2	42	51	157	166	145	169	0.86
3	13	1	5e+02	2.2	42	51	240	249	228	252	0.86
4	13	1	5e+02	2.2	42	51	323	332	311	335	0.86
5	13	1	5e+02	2.2	42	51	406	415	394	418	0.86
6	13	1	5e+02	2.2	42	51	489	498	477	501	0.86
7	13	1	5e+02	2.2	42	51	572	581	560	584	0.86
8	13	1	5e+02	2.2	42	51	655	664	643	667	0.86
9	13	1	5e+02	2.2	42	51	738	747	726	750	0.86
10	13	1	5e+02	2.2	42	51	821	830	809	833	0.86
11	13	1	5e+02	2.2	42	51	904	913	892	916	0.86
12	13	1	5e+02	2.2	42	51	987	996	975	999	0.86
13	13	1	5e+02	2.2	42	51	1070	1079	1058	1082	0.86

Sequence Information

Coding Sequence: ATGACCCAGCTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAACTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAAGTCAGTACGTACCTGGTTCTGCATGCGCATGACCCAGCTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAACTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAAGTCAGTACGTACCTGGTTCTGCATGCGCATGACCCAGCTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAACTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAAGTCAGTACGTACCTGGTTCTGCATGCGCATGACCCAGCTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAACTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAAGTCAGTACGTACCTGGTTCTGCATGCGCATGACCCAGCTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAACTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAAGTCAGTACGTACCTGGTTCTGCATGCGCATGACCCAGCTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAACTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAAGTCAGTACGTACCTGGTTCTGCATGCGCATGACCCAGCTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAACTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAAGTCAGTACGTACCTGGTTCTGCATGCGCATGACCCAGCTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAACTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAAGTCAGTACGTACCTGGTTCTGCATGCGCATGACCCAGCTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAACTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAAGTCAGTACGTACCTGGTTCTGCATGCGCATGACCCAGCTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAACTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAAGTCAGTACGTACCTGGTTCTGCATGCGCATGACCCAGCTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAACTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAAGTCAGTACGTACCTGGTTCTGCATGCGCATGACCCAGCTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAACTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAAGTCAGTACGTACCTGGTTCTGCATGCGCATGACCCAGCTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAACTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAAGTCAGTACGTACCTGGTTCTGCATGCGCATGACCCAGCTGACGTCGCCGGTGGGCGAGCGCACGTGCACCTCGGCCCAGCCCGCGCACCAGCACGGACACTGCCCCGCAGCCGTCAGCTCGCCCACGCGCGTAGTTGCAGTAAGTCAGTACGTACCTGGTTCTGCATGCGCATGA
Protein Sequence: MTQLTSPVGERTCTSAQPAHQHGHCPAAVSSPTRVVAVTDVAGGRAHVHLGPARAPARTLPRSRQLAHARSCSKSVRTWFCMRMTQLTSPVGERTCTSAQPAHQHGHCPAAVSSPTRVVAVTDVAGGRAHVHLGPARAPARTLPRSRQLAHARSCSKSVRTWFCMRMTQLTSPVGERTCTSAQPAHQHGHCPAAVSSPTRVVAVTDVAGGRAHVHLGPARAPARTLPRSRQLAHARSCSKSVRTWFCMRMTQLTSPVGERTCTSAQPAHQHGHCPAAVSSPTRVVAVTDVAGGRAHVHLGPARAPARTLPRSRQLAHARSCSKSVRTWFCMRMTQLTSPVGERTCTSAQPAHQHGHCPAAVSSPTRVVAVTDVAGGRAHVHLGPARAPARTLPRSRQLAHARSCSKSVRTWFCMRMTQLTSPVGERTCTSAQPAHQHGHCPAAVSSPTRVVAVTDVAGGRAHVHLGPARAPARTLPRSRQLAHARSCSKSVRTWFCMRMTQLTSPVGERTCTSAQPAHQHGHCPAAVSSPTRVVAVTDVAGGRAHVHLGPARAPARTLPRSRQLAHARSCSKSVRTWFCMRMTQLTSPVGERTCTSAQPAHQHGHCPAAVSSPTRVVAVTDVAGGRAHVHLGPARAPARTLPRSRQLAHARSCSKSVRTWFCMRMTQLTSPVGERTCTSAQPAHQHGHCPAAVSSPTRVVAVTDVAGGRAHVHLGPARAPARTLPRSRQLAHARSCSKSVRTWFCMRMTQLTSPVGERTCTSAQPAHQHGHCPAAVSSPTRVVAVTDVAGGRAHVHLGPARAPARTLPRSRQLAHARSCSKSVRTWFCMRMTQLTSPVGERTCTSAQPAHQHGHCPAAVSSPTRVVAVTDVAGGRAHVHLGPARAPARTLPRSRQLAHARSCSKSVRTWFCMRMTQLTSPVGERTCTSAQPAHQHGHCPAAVSSPTRVVAVTDVAGGRAHVHLGPARAPARTLPRSRQLAHARSCSKSVRTWFCMRMTQLTSPVGERTCTSAQPAHQHGHCPAAVSSPTRVVAVTDVAGGRAHVHLGPARAPARTLPRSRQLAHARSCSKSVRTWFCMRMTQLTSPVGERTCTSAQPAHQHGHCPAAVSSPTRVVAVSQYVPGSACA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -