Basic Information

Gene Symbol
egg
Assembly
GCA_949774965.1
Location
OX459024.1:3852341-3871301[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 0.5 2.1e+03 -0.6 0.1 28 38 280 302 262 304 0.67
2 2 4.6e-14 1.9e-10 41.2 0.0 4 72 334 395 331 400 0.85

Sequence Information

Coding Sequence
ATGTCTTCCTTCAGCTGTACCAAACGAGACTTCATAATCCCCTATATCGAGGGCGGCAAGACCAGGGAATCATTATCTAAAGTTTTAGTGGAAAAGCTCAATGTTTCTGAAAACaacttgtgttttataattAGTGACATACAAAGGCACATTCTTCCTATTTTCAACAAGCGCTGGGCCCTGGCATCTCGgaaaaaagaaacatatttaCAGAAGAATTGTACTTGGTTGGACTCAAGGTATTCGTTAAATTTACCGGATTCTGAACAATATTCTACGCCATCAACATCTGACCAACGAGGAAGAGCATGCGTGGCTTATGGAGACTCCTCAGAATCTACCAAGAAGAGGAAAAACACTCTTCTACTCCAAGAATATGGCTTCGAGCATATAAAAAACGCCTATGTGCAGGGACTACGGGCTTTACGTGAGTACACAGAAGCTCATCTTGTCGAAGAATTAAGAACCACTGACACTCAAAAGAAATTAGATATCTCAAGAAAATGGTGGCCAGCCAAGGTGGTACAAGTAGACGCATCACTATCTCAAGTGATGTTCGTGCACGACGGACGGCGCGAGTGGATCTACCGAGGGTCAACACGACTGGCACCCTTGTACCTTGAGCTGCAAGCCGCCGAGAGACACCGGGTCCGGCCCATGCCTAGGAGCAAGGCTCAGCCGAGGTCGAACATGCCATACGTGGAGTACATCCGATCAGATGAGCAGGAATCTCAGCTGGAAGCGCAGGCGCAAGCTCAGCAACAGATGCGGCAACAACAGTTGCAACGAGATGAGGAGATTCGTCGCCAACGCGCCGTGgccaagaagtctacatcagcACCTACTCAAACGCCGGTCGTCGCGCCATCTACTGTGGAGCAAAGCAGAGTTGTGTACTACACACCAAAGAATGCAGTCAAGCCATTGAAGATGGTACCTCATAAATGCGGTACTAATTGCAAGAGGAGTGACATTCTCTCTCTTAAGGAATTGAGGACTTACAACCCGCTGGCGAAACCGTTACTGAGCGGATGGGAGAGACAAATAGTCCGTTACAAGGGCCACAAAGACGTAATGTACCGAGCGCCGTGCGGCCGGCGCATACGCAACATGTACGAGCTACACAGCTACCTGCGCGCCACAGAGAGCGTGCTACCAGTGGACCTGTTCGACTTCCACTACTTAACGCATTGTCTCTCCGAGTACGTATTCAGCAAGTGCCTTGTGATGAAGAAGGATCTCTCCCACGGCAAAGAAAACGTGCCGGTGCCATGCGTGAACTACTTGGACGACTCGCTGCCGGAGTTCTGTTCGTACAACACCGAGCGCACGCCCACTGCCGGGGTGCCGCTCAACTTGGAGCCCGAGTTCCTGTGCGGCTGCGACTGTACCGATGACTGTCAGgATAAATCAAAATGCGCTTGCTGGAAGATGACGCTAGAGGGCGCTCGGACCATCGGCCTGGTCGGGCCTAATGTGGGCTATGCCTACAAACGACTGCCCGAACCGTTACCTTCTGGAATATATGAATGTAATTCTAGGTGCAAATGCAAGCATACGTGTCTGAATCGCGTGGCACAGCATCCATTACAATTGAAGTTGCAGGTATTCAAAACCCCTAATCGTGGTTGGGGTATCCGCGCACTGAACGACGTTCCCAAAGGGTCCTTCCTCTGTGTGTACGCTGGTAACCTGCTCACCGATGCTACGGCTAACTTGGACGGTTTAAATGAGGGCGACGAATATTTAGCAGAATTGGATTATATAGAAGTTGTCGAACAAATGAAGGAAGGATATGAAGAGGACATACCTGATGCTGATAAGAAATTAGACAAGAAAGAAAAAGGTAAAGAAGACGAAGAAAGctctgagtcatcatcatcatctgaggATGAGGAGCCTGCCTCCAAGACTGACAAGGAGGACGATGACTTCAGACCTGCGTTCTTTGCAGGAGTAGCACCTGGCGTTGCGGAGTTCAACAAACGCCTCCGTAAACGCGAGAAATCAAAGAAAGATAAGGAAAATGCGGCGGCTGAcgaaaaagataaagaaaaatataaagatcCTAAAGAACCAAAGGAAGGGAATGCTGATGAGGATTGTATTACtattagtgatgatgatgaagTACGAGTACCTTCAAGCTTCATGGCACAAACAAACATGGGAGCTAACGAGTATATATCTAAATACAAATCTGTTCGCACACTGTTCGGTAATGACGAGGCGTGCTATATCATGGACGCTAAGGTTCAAGGCAACATTGGCAGATATCTCAATCATTCCTGCTGCCCCAACGTATTCGTACAGAACGTCTTCGTGGACACCCACGACCCTCGGTTCCCGTGGGTGGCATTCTTCGCGCTATGTTACATAAAGGCTGGTACAGAACTGACGTGGAACTACAACTATGATGTGGGTTCGGTTCCCGGCAAGGTGCTTTATTGTTACTGTGGCGCCGTTAACTGTAGGGGGCggcttttgtaa
Protein Sequence
MSSFSCTKRDFIIPYIEGGKTRESLSKVLVEKLNVSENNLCFIISDIQRHILPIFNKRWALASRKKETYLQKNCTWLDSRYSLNLPDSEQYSTPSTSDQRGRACVAYGDSSESTKKRKNTLLLQEYGFEHIKNAYVQGLRALREYTEAHLVEELRTTDTQKKLDISRKWWPAKVVQVDASLSQVMFVHDGRREWIYRGSTRLAPLYLELQAAERHRVRPMPRSKAQPRSNMPYVEYIRSDEQESQLEAQAQAQQQMRQQQLQRDEEIRRQRAVAKKSTSAPTQTPVVAPSTVEQSRVVYYTPKNAVKPLKMVPHKCGTNCKRSDILSLKELRTYNPLAKPLLSGWERQIVRYKGHKDVMYRAPCGRRIRNMYELHSYLRATESVLPVDLFDFHYLTHCLSEYVFSKCLVMKKDLSHGKENVPVPCVNYLDDSLPEFCSYNTERTPTAGVPLNLEPEFLCGCDCTDDCQDKSKCACWKMTLEGARTIGLVGPNVGYAYKRLPEPLPSGIYECNSRCKCKHTCLNRVAQHPLQLKLQVFKTPNRGWGIRALNDVPKGSFLCVYAGNLLTDATANLDGLNEGDEYLAELDYIEVVEQMKEGYEEDIPDADKKLDKKEKGKEDEESSESSSSSEDEEPASKTDKEDDDFRPAFFAGVAPGVAEFNKRLRKREKSKKDKENAAADEKDKEKYKDPKEPKEGNADEDCITISDDDEVRVPSSFMAQTNMGANEYISKYKSVRTLFGNDEACYIMDAKVQGNIGRYLNHSCCPNVFVQNVFVDTHDPRFPWVAFFALCYIKAGTELTWNYNYDVGSVPGKVLYCYCGAVNCRGRLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01030263;
90% Identity
-
80% Identity
-