Basic Information

Gene Symbol
Mbd2
Assembly
GCA_000475195.1
Location
CP125326.1:3266761-3269382[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3e-21 1.4e-17 64.5 0.2 3 58 15 70 14 83 0.89
2 2 0.00046 2.1 9.5 0.1 28 74 96 155 83 158 0.84

Sequence Information

Coding Sequence
ATGAGTGATGGAGTTTCTAACTTGTTGAAAATGTTGCCCACCAAGAAGCGGTATGAATGTCCTCAGCTGCCTCCAGGATGGTACCGGGAAGAAGTAACGAGAAATAAAGGATTGTCAGTGGGCAAAGTTGATGTCTTCTACTATAGTCCCTGTGGTAAAAAGCTGAGAACAAGAAGTGAGGTTCTTCAAGTAATCAGAGGAAATATTCCAGGAGTATCCTTTGACTTCAGATCAGGCAAACTGAATTCTTTACAAAAACATCGCAATAAACAGAGGGGCAATCAATTTGAATACTgTCGTGGCGTCCGAAATGATGCATCATTAGTGCCTCCAATTAGACAAACAGCTTCCATATTCAAGCAGCCTGTTACAGTGTTCAAAACTCAAGAGAGCAAAGTCAAGACTGAAATCAAACAAGGCACACAAGAAAAACCAAAACAGTTGTTCTGGGAGAAAAGACTGGAAGGTCTGCGAGCATGTGATACAACTGGATCTGAATTGACTCCTATGGAATTGCCTAAGACATTGAAATCTGTAGGACCTCATGTTCGAGAAGAAACCATTCTACAATCAATAGCCACCGCATTGCATGTGCTTCCCCATCCAGTCACCGGACAGGGAGGTAATAAATCAAACCTAGAGAAGAGTCCTGGAATATTCCTGAACCCAGAACAGCCCCTCATAATGGGTGTCTCCATCACAGAAGAAGATatcaagaaacaagaagaaaaagtgtcCAGTGCCCGCAGCAAACTGAGAGAAGCATTGAAAAGAATTTAA
Protein Sequence
MSDGVSNLLKMLPTKKRYECPQLPPGWYREEVTRNKGLSVGKVDVFYYSPCGKKLRTRSEVLQVIRGNIPGVSFDFRSGKLNSLQKHRNKQRGNQFEYCRGVRNDASLVPPIRQTASIFKQPVTVFKTQESKVKTEIKQGTQEKPKQLFWEKRLEGLRACDTTGSELTPMELPKTLKSVGPHVREETILQSIATALHVLPHPVTGQGGNKSNLEKSPGIFLNPEQPLIMGVSITEEDIKKQEEKVSSARSKLREALKRI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01132199;
90% Identity
iTF_00442720;
80% Identity
iTF_00442720;