Basic Information

Gene Symbol
Ubtfl1
Assembly
GCA_000475195.1
Location
CP125331.1:26001463-26006143[-]

Transcription Factor Domain

TF Family
HMG
Domain
HMG_box domain
PFAM
PF00505
TF Group
Other Alpha-Helix Group
Description
High mobility group (HMG) box domains are involved in binding DNA, and may be involved in protein-protein interactions as well. The structure of the HMG-box domain consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. Many of these proteins are regulators of gene expression. HMG-box proteins are found in a variety of eukaryotic organisms, and can be broadly divided into two groups, based on sequence-dependent and sequence-independent DNA recognition; the former usually contain one HMG-box motif, while the latter can contain multiple HMG-box motifs. HMG-box domains can be found in single or multiple copies in the following protein classes: HMG1 and HMG2 non-histone components of chromatin; SRY (sex determining region Y protein) involved in differential gonadogenesis; the SOX family of transcription factors [1]; sequence-specific LEF1 (lymphoid enhancer binding factor 1) and TCF-1 (T-cell factor 1) involved in regulation of organogenesis and thymocyte differentiation [2]; structure-specific recognition protein SSRP involved in transcription and replication; MTF1 mitochondrial transcription factor; nucleolar transcription factors UBF 1/2 (upstream binding factor) involved in transcription by RNA polymerase I; Abf2 yeast ARS-binding factor [3]; yeast transcription factors lxr1, Rox1, Nhp6b and Spp41; mating type proteins (MAT) involved in the sexual reproduction of fungi [4]; and the YABBY plant-specific transcription factors.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 6 6.3 5.2e+03 -0.6 1.3 36 48 112 124 109 125 0.88
2 6 9.5e-14 7.8e-11 43.7 2.4 1 65 133 197 133 201 0.92
3 6 6.9 5.7e+03 -0.8 0.0 11 29 199 217 197 218 0.78
4 6 0.00044 0.37 12.7 0.3 2 59 223 276 222 286 0.82
5 6 1.9e-08 1.5e-05 26.7 1.3 2 68 309 373 308 374 0.91
6 6 0.0038 3.1 9.7 9.9 37 65 428 456 424 458 0.92

Sequence Information

Coding Sequence
atgGACTTAGCAAATAATGTTGTCAGTGACTCTTCTGACATTGAAGATCATCAATCACCAAAGCCAAAAAAGTCTAAACCAAATGGTGTTCCTAGCAATTCAGAGAACATCCTTGATTCACTCTCTCAAAAAGAGATCTCATTATTTTTGGACAGAATGCAAGAGAATTTAGATCCAAAACTAGATAAAAGCTCATATAAAAGTGGTGTACAGAAGTATGATTGGACAAAGatccACTTCAAATATTTCACCCCAGAACAATGTCAACATCTTTGGGAAGAAATTCAAACTCATCAAAGAAAGTTTCGCACTTTGGGAGATCTATTAAAGGATGCAAAATCTTGGAATGAagaaccaaagaaaaagaaagcaacaaAGAAAGTAATAGAGGGACTACCCAAGAGGCCCATGAGTTCTTACATGGTGTTTTTCAAGAAAGAAtacaagaagatgaaagaaaaagatccAACAATGTCATGTATAGCTGCTTCGAAAATAGCGTCTGAAAAATTTAAAACGTTATCTCCACATAAAAAAGCTTGCCTCATGGAAGAAGTTCAGGCTGGGGTGGATGCCTACAAAACGAAAATGGTTCTGTTTCAAGAGGAGCACCCTGACTTTGTGGCAGAGAAACCTGTTTCACAACCAACTGAACAGCATGCCCCAAACACCCCACGAAGTCCTTTCAAAATATTCTATGATGAAAAAGCTTGCAAGTATCCTAAAGGGGATGTGAAAAATCTACAGGCAAAATTGAAAGAAGATTGGAACAGTTTGGACGATCGCCAAAAAGTTGAATATATCCACCAGGCTAAAGTAGAATATGTAACCAAGACTGCAGACAACGACCAACTTCGTCAGAGCAAACCTAATGTcagcaaagaagaagataaaatttaCTTCAgtatattaggaGTCCCAGTAAAGCCACCTTCCTCCGGTTATCTCCTGTTCTCTCAAGAGTATTTGCAATGTGAGGAATCAAAGTTCTTAACAACGAAGGAACGAATGAAAGTTCTGTCTGAAAAATGGCATAGTCTTACTgcagtggaaaagaaagaatacaaGACAAGACAGAAAGAGaaACATTTGCAGTATGATAAGGATTATTCAGACTTCTTGACTAGATTAAAGTCAACTGAACTTTCCAACTTTTTGAAGTACAACATTGTTCCCTACAGTGCCGGCAACGTTACTACGGTTGctgaagaggaagtagaagtaGATAAGTTCCCTAAATCGGCGCGAGCATTTTTCAAGCTGAAAACTGGACAGTCAAAGGCAGAATGGAAAGAGTTGGAagtggaggaaaaggagaaatggaagaagaagttcgagaaaaagcggaaaaaaatagagaagcATAATGCATCTGCCTCTCAAGATTCCGAgttCACGCTAGCACCACCTCTATACAATTCCACACCTATGGTTCAGAACATCAATGGCAAAAGACTTCAGTCTTAG
Protein Sequence
MDLANNVVSDSSDIEDHQSPKPKKSKPNGVPSNSENILDSLSQKEISLFLDRMQENLDPKLDKSSYKSGVQKYDWTKIHFKYFTPEQCQHLWEEIQTHQRKFRTLGDLLKDAKSWNEEPKKKKATKKVIEGLPKRPMSSYMVFFKKEYKKMKEKDPTMSCIAASKIASEKFKTLSPHKKACLMEEVQAGVDAYKTKMVLFQEEHPDFVAEKPVSQPTEQHAPNTPRSPFKIFYDEKACKYPKGDVKNLQAKLKEDWNSLDDRQKVEYIHQAKVEYVTKTADNDQLRQSKPNVSKEEDKIYFSILGVPVKPPSSGYLLFSQEYLQCEESKFLTTKERMKVLSEKWHSLTAVEKKEYKTRQKEKHLQYDKDYSDFLTRLKSTELSNFLKYNIVPYSAGNVTTVAEEEVEVDKFPKSARAFFKLKTGQSKAEWKELEVEEKEKWKKKFEKKRKKIEKHNASASQDSEFTLAPPLYNSTPMVQNINGKRLQS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00442656;
90% Identity
-
80% Identity
-