Basic Information

Gene Symbol
-
Assembly
GCA_001412515.3
Location
NW:8693-201029[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3.4e-11 1.3e-07 30.5 0.3 12 71 235 292 229 295 0.82
2 2 0.82 3.2e+03 -2.8 0.0 7 27 353 372 349 376 0.72

Sequence Information

Coding Sequence
ATGGATATACAAGTCAGTGATACGAATGGCGGGAACGCCGAGGTGGCGCGCACGGAATCTAACCTGCAAGCAATTGTGGAATCTAAGTTAATGGCAGAGCAAACTCTTAACTCAGATAAATTACAAAGTGCAAAGAAAATGGACGAGGATGAGGTAAATGGTGAGGATAAGAGTGTTGGGAAGAAGTTGGAGTCAGCGGGGAAAAGAAGAATGCGTCAATCAAAGTCAAATTCGACTAGTAGTGTGGAAGCTGACGCCAAGCCTAAGGCTAAGGGAGTTAAGAGAAAACTCTTGGAGCCGGATGGTATTAATGAAGATGAATCTGCAGAGTTTGTTGGTTTTTCATCGGAGAgtatcattattattgagaCTGGATTGCAAATTCTTCAGAAACTTATTGTGGAAGCAGAATTGGAAGAATCCAATGCTATAAAACGTCGGCGGGCATCTTCGAAAGGAATTCAGAAGAACCTTCTGTCAAAAATAACTGCTGAAAGCCTCGAAAAAGAAACTACTGACGATAATAAGAGTATATCAATAACTTCCGAAGAAAAGCCAAAAATAAAAGACGATAAAGAGCCCAAGAAAATCGACACCATTACAACAGATCCGCCAAATTTTTGCAACAACCCCGAATCTAAGGGAGCATCTAGTAACAGTCAGAACGTTGATATGTCGAATCCCCTGTATAAAGAGCCCTTCAAATTTGGTTGGAAGCGTGAAATGATTTACAAGGGTGGATTTGAAAGTACTGCAAAGAAATCGGCAGACATTTATTATTACTCTCCCAAGGGAAAGAAAGTTAAGAGTCTTCGAGAAGTTGCAGAGTGTTTGACAACAAAGGAACTTTCTTTAGACAACTTTACGTTTTATAAAGAGCCAATTGGTATTGACGACCCTTCTATGGAAGTGATTAGGGACGCGAAGAGGCTTAGATCAGAATCGGCAGGTGGTCAAGTCACACCTACAAAAAAAAGCTTGAATAAACGTTCATCGCTCACTAGGAAAGTGCTGACACCACCTCCATGTCCACCTAAAACTGTCAAGATCTCGCCTTCCAAGGGCACGACTCCTGCAGGATTCAAGGTCAAAGTTGCGAGCAAGCGAGGGGCTCAAAAGAAGGAAGTGAAACCATCAAAAGAAACTGAACAACGGCCACCCCAGTGGAGTTCTCACAATGTGACAAGAAAAAATCAGGCAGCTGCTGAAAAAGTTACATCCCCAAAAAATAAAAGGATATTGAGCAGAGCCAAACTCCAGGAGCCCTGCAGCATTCGATGTTCGATGAGCATGGGTCTCATTCCAAGTCTCCAGTGTCGCATTTGTCTATGTTTATATCATCCAGAGTGTGTTGGTGGAAAAACTATATCAGCTAACGAGGAATACGTCTGCAAGAATTGTCAAATGGAGTTAGAACCAAGTGAACGTCATCAGCAACAACCGTTGATAACGCCACCAGCGTTGATACCAATAAGCATGTTAGGCTCTCACACCATAAAATCGAAGCTCCCAAAGCCCCACCAATCGTCAAAACCAGAGACTGAAGAACCCCTAAAAGACAAAATCCCCATGTCAAACTTATCAGAAGTTCCTTCAGTCATTGACAACGTAGATACTTCACTAAGTTCCTGGTTTTCTCCCCCAgggaaaaaatttcttcataatcATGGTGGATGCAAACTTCAACCTGCCCAAAATATTGCAAAAATGGGGGGGAAACGTTACATTGTTGTTCCCAAGAACAATGATATGGCTGTGCAACCAGCAATTCCCATCAGACCTGACCGAACGGTCGAAAATCAAAGAGATtttattcgagaaaattcattgattaataTAAATTTGAGTACAGAGAACTCGATTAGCAGTCGAAGATCCTCTCAGTCAGGTGTGAAGTATACTCCAGACAAAGAGAACGAAATAACTAAGAAAGTGGCTGAAGCAATGGACGTCGAAAGTCCTTTGAATGATTCAATCAGCAAAGATATGGGGATTTGTTGTAACAAAGTGAAAAGCAGCGGGGTTGAACCTGCTGTGCAGACAATGGAAGTACACATGGATGTGGAGGCTGTTGAACTagataaaaatttggaaattgaatGGTTGGATGGTTCACGTCTGCCACCGGCTGAGTCATTAAATGGGTCACATTCGTCACAGATTGAGCCTATGATTGCGCTGACAAATAAAAATGAGGTGGAGAGTGAAATGGCTGAGGAAAGAGGGGAAAAAGTGGAATGTAATAACAAAGTTCAAAAAGCAATGGAGACTCCACTTCTGCCTCCTGAGAATCAGAAAAACGAAGAGGTTGAGAATTTTAACACAAAATGTGATAGCAGCACTAAAAAGAAAATTCCTCCAATGGAGGTAGACCCAAAGCAATACTTTATGGTATCAGTGTGTGCAGGATATCACGCATTATCCCGCATCTTTCAGTACCTGAAGGTTCAGGAGCTCCTTCGTGCGGCTCGAGTCTGTAGAATGTGGAGAGATTTGGCAGCTCATCCAGCACTCTGGAAAACAGTGAGGATGAAGAACAGTCAGGTAGCAGATTGGGATGGGTTGGCAGCATCTCTAAAGCGCCATGGAACACAGCACTTGGACTTGAGAAAGATGTTAGTAGCCGGAGAGGCGGATAATATTTGGGACAAATTTGTTTCCATCCTCCCTAATGTTCCAAGTTTAACGATCTTGGAATTATGCAGATGTCCAGCGTCTGTTGTCGAGGAGATATTCAAATGCTGTCCCCAGTTGGAGGTAATGAGTGCAATGGCGATCAAATGCGATGCACTCAATATCGAGTCTCTAGGGAATGTCAAACATCTGAAGGAATTGAAACTCAAGGCAATCAGTGGAATGTCACTTCAGGAGGATTTCTCGCCACTGGGCGAACTCAAACACTTGACGCAACTGAATCTAACGTCAGTCAAAGAacttggaaagaaaaaaattgaagtccTCGGAACTTTGACTAGCCTGGAGACTCTGGAACTTGGAGAATGTTCCGATTTCCCCGATCGATTTGGGACTGATGTACTTTTGAAGCTGACTAACTTGGAGAGATTGAGATTGGAGAAAGGGCAGGGCTCTTGTTGCACTTTCGATATTCTGGAGGGGGTCTCCAAGCTGGGAAACCTTCGTCAGCTCGAGCTGGTGAATTTTGATGTGAAAAATGGATTCGATAAGTGTCTAGCTAATTGCAAGAATATCAAAAGACTGCTGATTATTCCTACGTATATTTCACAATCGGCTACTTCGAATAATATGGTCCTGGGGGGAGTCACTAAGTTGAGCGATAATCTAACGCACTTCGTGTGGGGAGTTACGCTGGAGTTGTTGAGAGTTACTGAGCTGTTTGTCGATcagtgtaatcaaatgaataaGCAGGTCTCTGGCGACTCCATTCCGGTGCTGAAGCCGGTTCCTTGTTTGAAGTTGATTGAGGATATTGAGGTGAAACAGGATGCACCAAAAGAGGAGAGACAATCAACCTTAACAAATCCACAAGTGGACATTCTTCCCCTCCCTCAACTTCAAAAACTATTACTTACTGCATTGCCCAAAACCAGagtgaaaatattgaagatCCCGTTCCACGCAACCTGGAGGCAGAGTATATCTGACAACACATCGCCGTAA
Protein Sequence
MDIQVSDTNGGNAEVARTESNLQAIVESKLMAEQTLNSDKLQSAKKMDEDEVNGEDKSVGKKLESAGKRRMRQSKSNSTSSVEADAKPKAKGVKRKLLEPDGINEDESAEFVGFSSESIIIIETGLQILQKLIVEAELEESNAIKRRRASSKGIQKNLLSKITAESLEKETTDDNKSISITSEEKPKIKDDKEPKKIDTITTDPPNFCNNPESKGASSNSQNVDMSNPLYKEPFKFGWKREMIYKGGFESTAKKSADIYYYSPKGKKVKSLREVAECLTTKELSLDNFTFYKEPIGIDDPSMEVIRDAKRLRSESAGGQVTPTKKSLNKRSSLTRKVLTPPPCPPKTVKISPSKGTTPAGFKVKVASKRGAQKKEVKPSKETEQRPPQWSSHNVTRKNQAAAEKVTSPKNKRILSRAKLQEPCSIRCSMSMGLIPSLQCRICLCLYHPECVGGKTISANEEYVCKNCQMELEPSERHQQQPLITPPALIPISMLGSHTIKSKLPKPHQSSKPETEEPLKDKIPMSNLSEVPSVIDNVDTSLSSWFSPPGKKFLHNHGGCKLQPAQNIAKMGGKRYIVVPKNNDMAVQPAIPIRPDRTVENQRDFIRENSLININLSTENSISSRRSSQSGVKYTPDKENEITKKVAEAMDVESPLNDSISKDMGICCNKVKSSGVEPAVQTMEVHMDVEAVELDKNLEIEWLDGSRLPPAESLNGSHSSQIEPMIALTNKNEVESEMAEERGEKVECNNKVQKAMETPLLPPENQKNEEVENFNTKCDSSTKKKIPPMEVDPKQYFMVSVCAGYHALSRIFQYLKVQELLRAARVCRMWRDLAAHPALWKTVRMKNSQVADWDGLAASLKRHGTQHLDLRKMLVAGEADNIWDKFVSILPNVPSLTILELCRCPASVVEEIFKCCPQLEVMSAMAIKCDALNIESLGNVKHLKELKLKAISGMSLQEDFSPLGELKHLTQLNLTSVKELGKKKIEVLGTLTSLETLELGECSDFPDRFGTDVLLKLTNLERLRLEKGQGSCCTFDILEGVSKLGNLRQLELVNFDVKNGFDKCLANCKNIKRLLIIPTYISQSATSNNMVLGGVTKLSDNLTHFVWGVTLELLRVTELFVDQCNQMNKQVSGDSIPVLKPVPCLKLIEDIEVKQDAPKEERQSTLTNPQVDILPLPQLQKLLLTALPKTRVKILKIPFHATWRQSISDNTSP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00438756;
90% Identity
-
80% Identity
-