Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.01 62 6.5 0.1 25 50 10 35 4 37 0.90

2 8 0.56 3.3e+03 1.0 0.0 26 47 35 56 33 62 0.79

3 8 0.03 1.8e+02 5.1 0.0 22 46 59 83 44 90 0.87

4 8 0.011 63 6.5 0.2 25 50 90 115 84 119 0.90

5 8 0.049 2.9e+02 4.4 0.2 12 47 141 176 130 181 0.81

6 8 0.0042 25 7.8 0.0 22 45 179 202 174 205 0.89

7 8 0.016 94 5.9 0.0 21 50 206 235 203 239 0.85

8 8 0.11 6.5e+02 3.3 0.1 20 43 261 284 243 290 0.81

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.01	62	6.5	0.1	25	50	10	35	4	37	0.90
2	8	0.56	3.3e+03	1.0	0.0	26	47	35	56	33	62	0.79
3	8	0.03	1.8e+02	5.1	0.0	22	46	59	83	44	90	0.87
4	8	0.011	63	6.5	0.2	25	50	90	115	84	119	0.90
5	8	0.049	2.9e+02	4.4	0.2	12	47	141	176	130	181	0.81
6	8	0.0042	25	7.8	0.0	22	45	179	202	174	205	0.89
7	8	0.016	94	5.9	0.0	21	50	206	235	203	239	0.85
8	8	0.11	6.5e+02	3.3	0.1	20	43	261	284	243	290	0.81

Coding Sequence: ATGAAAATACATACTGAAGATAAGTCTTTTGCGTGTGAAATTTGTGCCAAAATGTTTTCACAAAGTTTCCATTTAAATGAACATATGGCAATACATACTTTTGCATGTAAAATTTGCTCCAAGGTGCTTTCAAAAAGATCCAGGTTAACAGACCATATGAGAGTACACACTGGGGATAAACCATTTGCATGTGAAATTTGCTCCAAAAAATTGTCAGCAAAGAGCACTTTAAAAAGACATATGAAAATACATACTGAAGATAAGTCTTTTGCGTGTGAAATTTGTGCCAAAATGTTTTCACAAAGTTTCCATTTAAATGAACATATGGCAATACATACTTTTGCATGTAAAATTTGCTCCAAGGTGCTTTCAAAAAGATCCAGGTTAAGCTCCAAGAGATTTTCACGAAGGTTCAGTTTAACAGAACATATGAGAATAGTACATATTGGAGATAAACCTTTTGCATGTGAAATTTGCTGCAAAAGTTTTTCACAAAGATCCAAGTTAGCAGAACATATTAGAGTACATACTGGTGATAAACCTTTTGAATGTAAAATTTGCTTCAAAAAGTTTTCACAAGGATCCGGGTTAAGAAAACATGTGACAGTACATACTAGCGATAAACCTTTTGCTTGTAAAATTTGCCTTAAGTGTTTTTCGCAAAGATCCAGTTTAACAGACCATATGACAGTACACACTGGGGATAAACCTTTTGCATGTGAAAGATGCTCCAAAAGATTTTCACAAAGAACCGGCTTATCACAACATATGAGAGTACATACTAGCGATAaacctttttcttgtgaaatttgcTCCGAAAGTTTTTCACAAGAATCCAGTTTAGCAGAGCATAATATGACAGTACATACATATGTATgtatagtttag
Protein Sequence: MKIHTEDKSFACEICAKMFSQSFHLNEHMAIHTFACKICSKVLSKRSRLTDHMRVHTGDKPFACEICSKKLSAKSTLKRHMKIHTEDKSFACEICAKMFSQSFHLNEHMAIHTFACKICSKVLSKRSRLSSKRFSRRFSLTEHMRIVHIGDKPFACEICCKSFSQRSKLAEHIRVHTGDKPFECKICFKKFSQGSGLRKHVTVHTSDKPFACKICLKCFSQRSSLTDHMTVHTGDKPFACERCSKRFSQRTGLSQHMRVHTSDKPFSCEICSESFSQESSLAEHNMTVHTYVCIV*

Sequence clustering based on sequence similarity using MMseqs2