Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.0079 47 6.9 0.2 21 48 85 112 77 118 0.86

2 7 0.82 4.9e+03 0.5 0.1 21 34 113 126 109 140 0.72

3 7 3.2 1.9e+04 -1.4 0.0 27 47 147 167 144 173 0.78

4 7 0.048 2.9e+02 4.4 0.1 21 44 169 192 163 196 0.84

5 7 0.00063 3.8 10.4 0.0 10 44 185 220 183 224 0.83

6 7 0.0014 8.4 9.3 0.0 21 51 225 255 220 256 0.86

7 7 0.0011 6.3 9.7 0.1 21 48 253 280 249 283 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.0079	47	6.9	0.2	21	48	85	112	77	118	0.86
2	7	0.82	4.9e+03	0.5	0.1	21	34	113	126	109	140	0.72
3	7	3.2	1.9e+04	-1.4	0.0	27	47	147	167	144	173	0.78
4	7	0.048	2.9e+02	4.4	0.1	21	44	169	192	163	196	0.84
5	7	0.00063	3.8	10.4	0.0	10	44	185	220	183	224	0.83
6	7	0.0014	8.4	9.3	0.0	21	51	225	255	220	256	0.86
7	7	0.0011	6.3	9.7	0.1	21	48	253	280	249	283	0.91

Coding Sequence: ATGGAACTCAAACGTGAAATTAAGCAAGAAGAAATTACCGTTGAAGACGTTAAGGATGAATCACCAGAAGGAGAAGATTCTTCAGATTCTCTGGAGAAGAACAAAATGGAAACAATAAAAGCATTACCTGAACATTCACGTGGTAAAAAACAGGTTGAAAAGGACACTGGAAGGAAGCTTTATGAATGCGAGACTTGTTTGAAAACCTTTACTAGACAATATGCTTTAAAAATACAcctgagagtacacactggagaaaagccataTGAATGCAAAATTTGTTCCAAGTCGTTTAGTCAAGCAAATGCATTGAGGATACATACAAGGATACATACAGGAGAAAAACCGTATCAGTGTGAGATATGTCTTAGAGATTTTTCCACCAATACTGAAATGAAAGAACATATGAGAAAGCACACTGGGGTAGCCTCTTACCAATGCGAAGTTTGTTCGAAGTTGTTTTTCAACGCAAGTAATTTCAGAGGACATAAGAGAGTACACACTAAAGAAAAACCGTATCAGTGTCAAATTTGTTTCAAGTCGTTTAACTTTCCGGGAAATTTGAAGGGTCACACTAGAATGCATACAGGAGAAAAACCGTACCAATGTAAAATTTGTTTCAAGTCGTTTGCTCAATCGTCTGATGTGAAATATCATATGACAAAGCACACAGGAGAAAAACCTCATCagtgtaaaatttgtttcaaGTCATTTACTCGGTCAGGTTCTTTAAAACAACACCACAGGTTACATACCGGGGAAAAACCTTATCAATGCAAAATTTGTTTGAAGTTCTTTGCCCAaccaaataatgtaaaaaaacatATGAGAGTGCTGCACCCTGAACAAAACTCTTCCTAG
Protein Sequence: MELKREIKQEEITVEDVKDESPEGEDSSDSLEKNKMETIKALPEHSRGKKQVEKDTGRKLYECETCLKTFTRQYALKIHLRVHTGEKPYECKICSKSFSQANALRIHTRIHTGEKPYQCEICLRDFSTNTEMKEHMRKHTGVASYQCEVCSKLFFNASNFRGHKRVHTKEKPYQCQICFKSFNFPGNLKGHTRMHTGEKPYQCKICFKSFAQSSDVKYHMTKHTGEKPHQCKICFKSFTRSGSLKQHHRLHTGEKPYQCKICLKFFAQPNNVKKHMRVLHPEQNSS*

Sequence clustering based on sequence similarity using MMseqs2