Basic Information

Gene Symbol
-
Assembly
GCA_030765065.1
Location
CM060984.1:255642875-255652697[-]

Transcription Factor Domain

TF Family
SRF
Domain
SRF domain
PFAM
PF00319
TF Group
Helix-turn-helix
Description
Serum response factor (SRF) is a ubiquitous nuclear protein important for cell proliferation and differentiation. SRF function is essential for transcriptional regulation of numerous growth-factor-inducible genes, such as c-fos oncogene and muscle-specific actin genes. A core domain of around 90 amino acids is sufficient for the activities of DNA-binding, dimerisation and interaction with accessory factors. Within the core is a DNA-binding region, designated the MADS box [2], that is highly similar to many eukaryotic regulatory proteins: among these are MCM1, the regulator of cell type-specific genes in fission yeast; DSRF, a Drosophila trachea development factor; the MEF2 family of myocyte-specific enhancer factors; and the Agamous and Deficiens families of plant homeotic proteins. In SRF, the MADS box has been shown to be involved in DNA-binding and dimerisation [1]. Proteins belonging to the MADS family function as dimers, the primary DNA-binding element of which is an anti-parallel coiled coil of two amphipathic α-helices, one from each subunit. The DNA wraps around the coiled coil allowing the basic N-termini of the helices to fit into the DNA major groove. The chain extending from the helix N-termini reaches over the DNA backbone and penetrates into the minor groove. A 4-stranded, anti-parallel β-sheet packs against the coiled-coil face opposite the DNA and is the central element of the dimerisation interface. The MADS-box domain is commonly found associated with K-box region see (IPR002487).
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.024 1.6e+03 1.4 0.0 15 23 148 156 137 156 0.85
2 12 0.028 1.9e+03 1.2 0.0 15 23 187 195 181 195 0.88
3 12 0.028 1.9e+03 1.2 0.0 15 23 226 234 220 234 0.88
4 12 0.024 1.6e+03 1.4 0.0 15 23 265 273 254 273 0.85
5 12 0.028 1.9e+03 1.2 0.0 15 23 304 312 298 312 0.88
6 12 0.028 1.9e+03 1.2 0.0 15 23 343 351 337 351 0.88
7 12 0.024 1.6e+03 1.4 0.0 15 23 382 390 371 390 0.85
8 12 0.028 1.9e+03 1.2 0.0 15 23 421 429 415 429 0.88
9 12 0.028 1.9e+03 1.2 0.0 15 23 460 468 454 468 0.88
10 12 0.015 1e+03 2.1 0.0 11 23 495 507 488 507 0.76
11 12 0.02 1.4e+03 1.7 0.0 15 23 538 546 529 546 0.82
12 12 0.028 1.9e+03 1.2 0.0 15 23 577 585 571 585 0.88

Sequence Information

Coding Sequence
ATGGACCCCGTCTCACTTGCCCCCATCGTCAGCCGGATCTGGTTGTCCTTCGGTTCTTATCTCCTCCTCGAAGGGGCCGCGgGGTTGCGGCTGTGCGTGCTGTGGGAGTTTAACCCTGATGTCGTTAAGGGACTACTCGGCTGGAACCCACCTGGGCGATTTCAGCTCCTTCAGGGATCCCCGGAGGATCGGAGCCCAGTAGAGTCGCCTCGGGCGGcgttggaaacgttaaggacatcgtCTGTGCTTCCGCCCGtcttcatccggatctggttgccttgGGTCTCTCCCGGGGTTCACGGTAGAAGGCAAAGGGCCGGATGGCCTTGTGCGTGGTGCTCTGCCCAGGTTTTCAGGGGCGGACTCCcatCTGGACAGAGACAAGGTAACAGAGGACGCTTGCACCTCGACTCAAGGCGGATCTATATctctaccacccccaggaggaacggattaaTGAAGGAGGCGATAGGCCGTAGTCAGACCGGCCGACAGAGACAAGGTAACAGAGGACGCTTGCACCTCGGCTCAAGGCGGATCTATGTctctaccatccccaggaggaacggattaaTGAAGGAGGCGATAGGCCGTAGTCAGACCGGCCGACAGAGACAAGGTAACAGAGGACACTTGCACCTCGGCTCAAGGCGGATCTATGTctctaccatccccaggaggaacggattaaTGAAGGAGGCGATAGGCCGTAGTCAGACCGGCCGACAGAGACAAGGTAACAgaggacacttgcacctcgactcaagGCGGATCTATATctctaccacccccaggaggaacggattaaTGAAGGAGGCGATAGGCCGTAGTCAGACCGGCCGACAGAGACAAGGTAACAGAGGACGCTTGCACCTCGGCTCAAGGCGGATCTATGTctctaccatccccaggaggaacggattaaTGAAGGAGGCGATAGGCCGTAGTCAGACCGGCCGACAGAGACAAGGTAACAGAGGACACTTGCACCTCGGCTCAAGGCGGATCTATGTctctaccatccccaggaggaacggattaaTGAAGGAGGCGATAGGCCGTAGTCAGACCGGCCGACAGAGACAAGGGAACAGAGGACGCTTGCACCTCGACTCAAGGCGGATCTATATctctaccacccccaggaggaacggattaaTGAAGGAGGCGATAGGCCGTAGTCAGACCGGCCGACAGAGACAAGGTAACAGAGGACACTTGCACCTCGGCTCAAGGCGGATCTATGTctctaccatccccaggaggaacggattaaTGAAGGAGGCGATAGGCCATAGTCAGACCGGCCGACAGAGACAAGGTAACAGAGGACGCTTGCACCTCGGCTCAAGGCGGATCTATGTctctaccatccccaggaggaacggattaaTGAAGGAGGCGATAGGCCATAGTCAGACCGGCCGACAGAGACAAGGTAACAGAGGACGCTTGCACCTCGACTCAAGGCAGATCTATGTctctaccacccccaggaggaacggattaaTGAAGGAGGCGATAGGCCGTAGTCAGACCGGCCGACAGAGACAAGGTAACAGAGGACACTTGCACCTCGGCTCAAGGCGGATCTATGTctctaccacccccaggaggaacggattaaTGAAGGAGGCGATAGGCCGTAGTCAGACCGGCCGACAGAGACAAGGTAACAGAGGACACTTGCACCTCGGCTCAAGGCGGATCTATGTctctaccatccccaggaggaacggattaaTGAAGGAGGCGATAGGCCATAGTCAGACCGGCCGACAGAGACAAGagttccctatTGATTCTAAGCTGGATGACACCGACGAGCTGCAcacagaaggcttccctctggccgAACCAGAGGGAACTCCACCTCCCGAGGCCGCTCAGATAAGGCTGGTATCTGACAGGGCCGAGAAAAATTTTCCAATCAGCaagtatctgcgccatctgtccgacaccgaatGCGAGGCCCGCACgttgccgcggagccatctctccCGGTTTCAAACTGTCTAA
Protein Sequence
MDPVSLAPIVSRIWLSFGSYLLLEGAAGLRLCVLWEFNPDVVKGLLGWNPPGRFQLLQGSPEDRSPVESPRAALETLRTSSVLPPVFIRIWLPWVSPGVHGRRQRAGWPCAWCSAQVFRGGLPSGQRQGNRGRLHLDSRRIYISTTPRRNGLMKEAIGRSQTGRQRQGNRGRLHLGSRRIYVSTIPRRNGLMKEAIGRSQTGRQRQGNRGHLHLGSRRIYVSTIPRRNGLMKEAIGRSQTGRQRQGNRGHLHLDSRRIYISTTPRRNGLMKEAIGRSQTGRQRQGNRGRLHLGSRRIYVSTIPRRNGLMKEAIGRSQTGRQRQGNRGHLHLGSRRIYVSTIPRRNGLMKEAIGRSQTGRQRQGNRGRLHLDSRRIYISTTPRRNGLMKEAIGRSQTGRQRQGNRGHLHLGSRRIYVSTIPRRNGLMKEAIGHSQTGRQRQGNRGRLHLGSRRIYVSTIPRRNGLMKEAIGHSQTGRQRQGNRGRLHLDSRQIYVSTTPRRNGLMKEAIGRSQTGRQRQGNRGHLHLGSRRIYVSTTPRRNGLMKEAIGRSQTGRQRQGNRGHLHLGSRRIYVSTIPRRNGLMKEAIGHSQTGRQRQEFPIDSKLDDTDELHTEGFPLAEPEGTPPPEAAQIRLVSDRAEKNFPISKYLRHLSDTECEARTLPRSHLSRFQTV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-