Dpon003734.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Dendroctonus ponderosae
Gene Symbol
MBD-R2
Assembly
GCA_000355655.1
Location
NW:542896-561568[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.1e-17 5.3e-14 50.8 0.0 5 71 437 502 433 508 0.92

Sequence Information

Coding Sequence
ATGGGCCGGAAATGTAGTGTGGAAAATTGTTCATCCGATTCCACGAAATCTGAGCATATTGGTGTGACATTTCACAAGGTGCCTCATCATACGGATGTACGCCCCAAATGGCTATCACTTTGCCGTATTTCTGAGCATCGATCCAAATCCAAGCTGCTGTATGTGTGTTCGCGACACTTTTTGCGCGCtgatttttgcagctttaaaGGCAGAAAGTACATGCTGAAGCAGGGCGTGTTGCCTAGTGTGTTTCCATGGGATAAGTCCAGATTGGAAGCGATCAAAGCTGAAGTTTCTGTGAGTAAAGATGGGGAACCTACGAAAAAAAGAGCCAGAGCTGGACGAAAGAAGGAGGCTAAACCAAAGCAAGTATGTGCGACGGAGTCTGGCCCTGGAGAAGAGAATCTAGAGCAGGACATTAAGAAAGAGTGTGAAGATCCTGATGAAGCTGCTCCGGAGGCTGATCTAGCCACCAACGTTACAGGCGATATAGTGTCTAGTATGGAATCAGATGAGCCTCAAGAGGAAGAATTCAAAGCTGAGCCCTTAGACAAGGACGAGATCAACGAGAGCACGAATCTTTTTGACGAACATCAAAGTTCCCAGTCCACATCTCAACAAGACTCTCCTTCAATTGACTTTAGTATTAATTCGAGCATTGAAGTGCTGGATAACAACAATATCTGGCATGTAGCTAAAATCAACGAAGTTGATTACGAGGAAAACGAGGTTCTGATCCATTTCGAAAACTCCGTCAACAAATGCGATGAATGGATTTCCATGTCAAGTCCCAGGCTCAGACCCATATACGTGGAGCCCCAACAAATCTTCGATGTCGGTGAGCGATGTATGGCTATATGGAGTGTTTCCAAAAAGTTCCCTGCTTccatttcgaaaaaactaGATAATGATTTCTACGAATTGCTATTTGATGATGGTTATGTCAAAGTGGTTAATGCTAGCAAAATGTCCAAGATAAGTCTAGCAAAGCCAGCGCAATCATCACCGCTGTTCGATCCAATAAAAAGCACCAAGCAGGAGAGGAGAGATAAAAAGAGGAAGATCAATGTTGCTGCACTATTTGCCAAACGTATTCGTCTCAACAACACCGAGGAGAAAAAAAGCAAGGGAAGCCCCGCTCCAGCAGCGCCAGTGGAGGAAGCCAACAAGTCACCAGCCTCTCAGGACGAAGCCCCAAATACAAATCAGGCTTTATCAGTTGACAATTGGCATCCAAGATGGGAAAATGGGAAACCGGTAGGTATTGAGTCGACCATCGAAAGCGTGGATGGTTTAAGAAAATCCACAATAGTAGCCGATCCGCGGATGCCTCCTGGTTGGACGAAACATCTTACTCAACGAATGTATGGAAACTCTATCGGCAAATGGGATACTGTCATTTTAGCACCGGATGGGAAGAAATTCAGGACCAAGCAGgaaatcaaaaattatcttgaaCTGCATCCTGGCATCGACGTGAATGTTGAGCTGTTCGACTTTAGTCTTTATCGTGGAAAAAGGAAAGGAAAACCCAAGGCAAAAGTTCCTGTTGAATCAGTTGCTCTACCCAAAGAGGAACCACCGGCACCTGTGGAAGAAACAAAACCAGCCAAAGCAGAAGCTTCTCTAGACTCCCCAACATgcctaaaaataatattcgaaAACGAAGCATTTAAATGTCCAATTGAAGGTTGTGGTAAGAATTTTAGACGGGAAAATTTGGCGCTGATGCACGTGAAACATTACCATCCTGAATATACGAAATATTTGGAATCGACGCCCAATGTGGCGGATTTGGCTTACGCCCGCACAGTCGGCGAAAACTTGGATCGTTCGCCAGGACCCGCCAAAGCAGCTGCATTAAAAACTGCTGATAAAACCGCGACTCCGAAAGTAGCCAAAGCGTCTGCCGGGGCTCATCTGGAGGCAGCTGCTGGTGGCTCATTTGCGCCTGACGTTAAAGTTAGAGATACTGAAATTATAAAGCTTCTAACGCAAAAACCTATAGAGGGTGGTGGAGAAAATCATCATTTGCCATCAGgTCTACCATCTAACATGTATCcagatattaaattaaaagatctTCTAGGGAAATCTGACGACTTAGCTATGCGTGATGATATTCACCTCAAGAATTTATGTTCGTCACGACCCTCTCAAGGTATTAAGACTCTGCTTCCAGTCCGCCACTCGAACGCCTTGCAATCAGACTTGACCGAGTCGAAGCGCAAGAAAGGAATCAATCAAGAGCAACTCGATGTCTCGAGGGGTAAAACTCCACACCATTCAGCTTCCACACTCGATTCGCCACATTTATCTCACCATCCACCTTTACCACACCAGTCTCAACAGGCCACGCCAATTTCATTGGGGCGAAGTAGCGGAGCGATCGATGGCAATCCATTTCCATCCGCCTTCGATTTAGCGCCACCGCCCGCTGAGCTCGAATCCTCGTTAGCTCCTACGGTTACTCAATTCGATGGCGTTATTATTGAAGGcggaaaaataatcaaattagaGCGAATGAAGCAAGAAGAGATCATCAACTGTACGTGCGGCTTCATCGAGGAGGACGGCCTGATGATTCAATGCGAATTGTGCTTGTGCTGGCAGCATGCTTATTGCAACAACATCCAAAAGGAGAGCGAAGTGCCCGAGAAATATGTCTGCTACATCTGTCAGCATCCGCTTCGAGAGCGGCAATCGGCCAAGTATGTGCACGATCAGGATTGGTTGAAACAGGGAGTTTTGCCGGTGACGTCGTTCCACAGCAAAGATAAACTGGAGATGGAAAGTCGCTttgctaaattgaaaaagtgccACGATGTTTCTGGCGGATTGCTGGAGCTGAGAGAGTATATGCATGCTTTGGCTACCAAGCTTAAAATTGCCGAAGTAAAAAACCATCCTAAACTATACTTGTGGTCGAAACCATGGGACAAACCAAAACTGCAGGAGAAGCCCGATAGCAAAGAGCAAAACGGCGACAGGAAGGCATCGCTGGACAGTCCCGAGCACCAGTACGtgaaaaacgaaattgaatTGACCAAAGAAGAATCTCCCAATCATAACATGCTAATGATGATCCTGAAGGGCAGCAAAGAAGAGATACCGATGCTGAATATCAATAGCAATTCGGCCCCGATTATACCGCGGCCCAAAGCAGCCATCGATTCAGCTGACTGCAGGTTGAACCTGCTGGAGCACATTTCTGATGCGGAATCGCTGGTGGATGAGCGGTTGGACTATTTTGAAAAGCAGCTGGATGATCTGGAGCAGGGCCTGAGCATCGAGGTGGAGGAAAAATATCCGAAAACAAGACAGACCTTACAGTTACTAATGAAAGACTTGGATACATTGAAACAGTTCAGTGAGTTGCCGATgaattga
Protein Sequence
MGRKCSVENCSSDSTKSEHIGVTFHKVPHHTDVRPKWLSLCRISEHRSKSKLLYVCSRHFLRADFCSFKGRKYMLKQGVLPSVFPWDKSRLEAIKAEVSVSKDGEPTKKRARAGRKKEAKPKQVCATESGPGEENLEQDIKKECEDPDEAAPEADLATNVTGDIVSSMESDEPQEEEFKAEPLDKDEINESTNLFDEHQSSQSTSQQDSPSIDFSINSSIEVLDNNNIWHVAKINEVDYEENEVLIHFENSVNKCDEWISMSSPRLRPIYVEPQQIFDVGERCMAIWSVSKKFPASISKKLDNDFYELLFDDGYVKVVNASKMSKISLAKPAQSSPLFDPIKSTKQERRDKKRKINVAALFAKRIRLNNTEEKKSKGSPAPAAPVEEANKSPASQDEAPNTNQALSVDNWHPRWENGKPVGIESTIESVDGLRKSTIVADPRMPPGWTKHLTQRMYGNSIGKWDTVILAPDGKKFRTKQEIKNYLELHPGIDVNVELFDFSLYRGKRKGKPKAKVPVESVALPKEEPPAPVEETKPAKAEASLDSPTCLKIIFENEAFKCPIEGCGKNFRRENLALMHVKHYHPEYTKYLESTPNVADLAYARTVGENLDRSPGPAKAAALKTADKTATPKVAKASAGAHLEAAAGGSFAPDVKVRDTEIIKLLTQKPIEGGGENHHLPSGLPSNMYPDIKLKDLLGKSDDLAMRDDIHLKNLCSSRPSQGIKTLLPVRHSNALQSDLTESKRKKGINQEQLDVSRGKTPHHSASTLDSPHLSHHPPLPHQSQQATPISLGRSSGAIDGNPFPSAFDLAPPPAELESSLAPTVTQFDGVIIEGGKIIKLERMKQEEIINCTCGFIEEDGLMIQCELCLCWQHAYCNNIQKESEVPEKYVCYICQHPLRERQSAKYVHDQDWLKQGVLPVTSFHSKDKLEMESRFAKLKKCHDVSGGLLELREYMHALATKLKIAEVKNHPKLYLWSKPWDKPKLQEKPDSKEQNGDRKASLDSPEHQYVKNEIELTKEESPNHNMLMMILKGSKEEIPMLNINSNSAPIIPRPKAAIDSADCRLNLLEHISDAESLVDERLDYFEKQLDDLEQGLSIEVEEKYPKTRQTLQLLMKDLDTLKQFSELPMN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00431498;
90% Identity
iTF_00431498;
80% Identity
iTF_00431498;