Basic Information

Gene Symbol
-
Assembly
GCA_949752805.1
Location
OX457109.1:2989026-2996733[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 19 1.5 1.2e+02 4.1 0.1 3 23 116 136 114 136 0.95
2 19 0.086 7.1 8.0 0.4 2 23 140 162 139 162 0.94
3 19 0.021 1.7 9.9 0.4 3 23 395 416 394 416 0.95
4 19 0.18 15 7.0 0.4 1 20 424 443 424 444 0.95
5 19 0.099 8.2 7.8 0.2 3 23 456 476 455 476 0.95
6 19 3.2 2.6e+02 3.0 0.4 1 23 492 515 492 515 0.86
7 19 0.0037 0.3 12.3 1.1 1 23 524 547 524 547 0.94
8 19 4.4 3.6e+02 2.6 0.3 8 23 598 614 595 614 0.89
9 19 0.00018 0.015 16.4 0.1 3 23 626 647 624 647 0.94
10 19 0.065 5.3 8.4 0.4 1 23 652 675 652 675 0.96
11 19 2.7e-05 0.0022 19.0 1.8 1 23 681 703 681 703 0.97
12 19 3.5e-05 0.0029 18.6 1.8 1 23 710 732 710 732 0.98
13 19 9.4e-05 0.0077 17.3 2.3 1 23 737 759 737 759 0.96
14 19 0.00017 0.014 16.5 2.1 1 23 765 787 765 787 0.98
15 19 8.6e-06 0.0007 20.6 1.1 3 23 795 815 793 815 0.97
16 19 0.00027 0.022 15.9 1.5 2 23 822 843 822 843 0.97
17 19 0.00093 0.076 14.2 0.7 2 23 851 873 850 873 0.97
18 19 0.00026 0.022 15.9 0.6 1 23 878 900 878 900 0.98
19 19 0.00083 0.069 14.3 0.9 1 23 906 929 906 929 0.98

Sequence Information

Coding Sequence
ATGACTTCCGACGAATCGGACGATGAACCACTAGCAGTGTTAGCggccaataaaaaaatgaacccTGAGAAATTCGATGGAATAGTTCTACCAAAAGATATTGTGATTGAACCCAAGaggaagaaaaagaagaaattgGTTGCTCCGAAAGGTTTATCCGTGACCATAAGCTTCCAGAATAAAGTTAAAAAGGTCGCACCTGTTGTTGAGCGGCCTGCGGATGTGTGGCTGTATTTAAAAGACCTCAATCCAAATGGTCCATACAGTTGTTTGCTCTGTTCAGATTGGTTTGTCAATAGATCGAAAATAATCATACACTATGTTCTTAACCACAAGAAAGACTTTTGCGGGATATGCCGTTACTTTGTACCAGACAGAGAGTCATGGTGGGCACACGTGAAGTTCCACACCCCATGGCCGTGTTCGCAATGTGTGGAGAATTTCCACTCAGAGAATGCGCTTCGTCAGCATTTAAGCAGCGTGCACAACCTCGTCCACTGCCGCCTCTGCCACTTCCGAGTATCAGACGACGATCAGTACAACACACATCTCTTCCAAAAGCATAACGTCACAAACGTCGCCACTAAAGACGACGAAGTTCTCTGGGAGATAGAATACGACGGTTGCGCCAAGTTCCAATGCTTCCTCTGCTCGAAAACGAATAATATGACTCGCATGTTCTTCAATCACTATATGGGATATCACCATTTCACGTTAAAATGCTTCACAAGGATTATATCTGGGAGGGATTCCCCATTTTTAGTCTGCGGTGCTGATGTCAGTGCTGAGTTTGTTGAGAACCAGTTAAAGACACAGTCCAGATGTGGCTATCTCACCATTGAGCATACGACAGAGCAAACAGAAAACAAAGGTATGGAACAGCCTATTAAGTCTGAAGAGCCTATAATTGTCACAGAAGTGAAGGAGGAAGTGATATCCGAACCCCTCAGTGAGATAAAATGTGATGTCGAACTTATCAAAGGTGAGGGTGATGATGAAGACGATATATCGAAAACTTACAAAGGTGACGAAGATTTCGACGTGACGCTCATGGAAATGGTTATGATACAGAAATGCTATTTTGAATATGTCAATGTGTTGCTGAATGAGATAAACATGAATGTTGTTCCGAAAGTTTCCAATATTGTGTATGAAAAGACTGTGCCGGAAGCTCCAGTGGATTGTGTTCTGTGTAAAATGAGTTTCGAAACGCCTCAAGAATATTCTTCGCATATGACCAAGATGCATTGTGTGAAATGCTCGCCAGTGTTTTCATGTAGGGTCTGTTCTTCTACATTCGAAACTAAGAACGAGCTTGACAACCACACGGTTCAAGAATTAGGCGATTTCGAAGACCTTTGGCTCTGCCAGTTCTGTGATAAAGAGTTTGATGATCGAGAAGGCGCGAGAATACATTTGACTGAACACTGGGATTTGATACAGATAGACAATTGCTTCAGCCCTCATTTAGGGTTCAAATGTAGATATTGCCCAACATTATTCTGGAATGAGACTGACAGAGAAGCGCATCAGGTTAAagtgcattttaataaatataaggaagaattttataaatgcgAAGAGTGCAATGAAACTTATAGTGATAAGATTTGGTACATATATCACTACTTCTCTCAGCACCTGAAGACGGATCAGCAGTTCCCCTTGCACATATTCAAGTGCACATTATGTTGTTCGGTGCAATGGGACATCCATCAGATTCGGGACCATTTTGACCACATTCATCCCGAGGCGAGGAAGGTTTTCTGCTCGTTGGAGCCTTGCAAGTACAAGCCACTTAGCCAACGGAAATCTTTTAAGATACATTTGAAGACTATCCACAAGCCATCAGGTCGTATAATCGGCGCAGTGAACTGTCCGATTTGCAGCCGAGAGTTTCGTAGTTCGAGAGCTCTGAGCGCACACATGGCTCAAGTACACGGACCAGGGAAGTTCAAATGCAAGATTTGTAGGGAGGCGTTGAATACGGCGGATGAAAGGAAACTGCACTACCTGATCCGTCACCCTGGCCAGCATCCGTTCGAATGCAACGAGTGTGGCAAGTCGTTCCAGTACAAGTCTTCACTGTACATGCACAAGCAGGAGCACTTGCCCAACAAACAGAGCTACACCTGCAACTTCTGCAAGAAGGTGTTTGCGAAGAAGGACTCGTTCCGCGAGCACCTGCTGATCCACGAGGGTCCGCGGCACGCGTGCTCGTACTGCCCCATGCGCTTCGTGCAGCGCTCCAACATGCTGCGCCACGAGCGCCGCCACACCGGCGAGAGACCCTACGCCTGCCCGCACTGCGAACGAACCTTCGCTGACAAGGGCGCCTGCACCTCGCACATCCGAACTCACTCGAAGACTCAATCCTACGGCTGTATGTACTGCGGCCAAACGTTTGTGCAGAAGTCAAAACTCACGTATCACATCAGAAAACACACTGGCGAAAATCTGGAGACGTGTTCCGTTTGCGCCAAAATATTCACTAGTGCTTGTTCGTTGCGAGAACACATGAAGATACACACTATGAATAAGCAGTCTGTCAAGTGTCCACTATGTGATCGCAAATACCAAGACGAGCGGTACATGCTACGGCATCTTCGTACGTCACACACTCAGGGCCACTTCACGTGCCCGCTGTGCCGCAAGTCCCTCACCAGCGCCGTGGGACTCCGCCACCACGTCATCACGCACAGCTCGCTCAAGACTTACAAGTGTCAAATATGTCCAAAAGGCTACTCAGCTCGCAAATCAATAGTGAAGCATCTACGCAGACGGCACGGCCTCAAAGGCAACGAGATCAACATAAGAGACTTCTACAATCGCCTCGACCCCAGAGAGTGCGAATTAGGCTTGGACGAAGAAATCATGACCAGCATCTTCGGACCCCCCAAGAAgatcataaaacaaatattattcagGAACTTCGTAAACTTAAATAACGGTCTGGATCTAAGTAAGAAACCAGATGAAAGCACACCGGAGGTTGGTGAGAAACCGCCTGAACCAGAAGCTTCTGAAGACAATTCTGATGATAGTAATTATGAGAGCAATGATGAAGCGAAGAAAGAAGCTGCCAAGCCTGTTAGTATCAAACAAGAGTGTCCTGAAAATGATGATGCAGAGGAATTAGAACCAACAGACTTTGTCAGTGTTAAAATTGAACCAATGGACGATGATAGTTCAGAGTATATTATTTAA
Protein Sequence
MTSDESDDEPLAVLAANKKMNPEKFDGIVLPKDIVIEPKRKKKKKLVAPKGLSVTISFQNKVKKVAPVVERPADVWLYLKDLNPNGPYSCLLCSDWFVNRSKIIIHYVLNHKKDFCGICRYFVPDRESWWAHVKFHTPWPCSQCVENFHSENALRQHLSSVHNLVHCRLCHFRVSDDDQYNTHLFQKHNVTNVATKDDEVLWEIEYDGCAKFQCFLCSKTNNMTRMFFNHYMGYHHFTLKCFTRIISGRDSPFLVCGADVSAEFVENQLKTQSRCGYLTIEHTTEQTENKGMEQPIKSEEPIIVTEVKEEVISEPLSEIKCDVELIKGEGDDEDDISKTYKGDEDFDVTLMEMVMIQKCYFEYVNVLLNEINMNVVPKVSNIVYEKTVPEAPVDCVLCKMSFETPQEYSSHMTKMHCVKCSPVFSCRVCSSTFETKNELDNHTVQELGDFEDLWLCQFCDKEFDDREGARIHLTEHWDLIQIDNCFSPHLGFKCRYCPTLFWNETDREAHQVKVHFNKYKEEFYKCEECNETYSDKIWYIYHYFSQHLKTDQQFPLHIFKCTLCCSVQWDIHQIRDHFDHIHPEARKVFCSLEPCKYKPLSQRKSFKIHLKTIHKPSGRIIGAVNCPICSREFRSSRALSAHMAQVHGPGKFKCKICREALNTADERKLHYLIRHPGQHPFECNECGKSFQYKSSLYMHKQEHLPNKQSYTCNFCKKVFAKKDSFREHLLIHEGPRHACSYCPMRFVQRSNMLRHERRHTGERPYACPHCERTFADKGACTSHIRTHSKTQSYGCMYCGQTFVQKSKLTYHIRKHTGENLETCSVCAKIFTSACSLREHMKIHTMNKQSVKCPLCDRKYQDERYMLRHLRTSHTQGHFTCPLCRKSLTSAVGLRHHVITHSSLKTYKCQICPKGYSARKSIVKHLRRRHGLKGNEINIRDFYNRLDPRECELGLDEEIMTSIFGPPKKIIKQILFRNFVNLNNGLDLSKKPDESTPEVGEKPPEPEASEDNSDDSNYESNDEAKKEAAKPVSIKQECPENDDAEELEPTDFVSVKIEPMDDDSSEYII

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01359103;
90% Identity
iTF_00820318;
80% Identity
-