Dalb021679.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Dasysyrphus albostriatus
Gene Symbol
ey
Assembly
GCA_946251825.1
Location
CAMIUB010000300.1:717314-774896[+]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3.6e-73 1.2e-69 233.0 0.7 2 125 92 215 91 215 0.99

Sequence Information

Coding Sequence
ATGTTTGCCTTGCAGCCTACACCGGCTATGGGAGCCGTCGTTGCCCCATGGTCAGGTTCAATGATGGATAGGATACCATCTTTGGATGATATGCCGCATAAAGACAATGTCATTGCCATGCGAAATCTACAGTATATGGGTACAGGAAAAGCTGCTGCTGTGGATACAACAACGGCCGAATCATCCTCTACTCCAACACACTCCTCATCGTCTTCATCATCGTCGTCATACTTTGCGGCGACAACTTATTATCACTTAACCGATGATGAATGCCATAGTGGAGTAAATCAATTGGGTGGTGTATTTGTTGGTGGTCGGCCACTACCGGATTCGACACGGCAAAAGATTGTCGAACTAGCACATTCTGGTGCACGTCCTTGTGATATATCACGCATCCTTCAAGTATCGAATGGATGTGTTAGTAAAATTCTTGGAAGATATTATGAAACTGGTAGCATTCGACCAAGAGCGATAGGTGGCTCTAAGCCGCGTGTAGCAACAGCAGAGGTGGTAAATAAAATATCGCAGTACAAACGTGAATGTCCAAGCATATTTGCATGGGAAATTCGTGATAGATTATTGCAAGATGGAGTCTGTACAAATGATAATATACCAAGTGTTTCATCGATAAACCGTGTCCTGAGAAATTTAGCAGCACAAAAGGAACAACAACAACATCCTTCAAGTAATCAACAAGGTAGTGGCGGTACTGGAGGAACGAGTGGTGGCAGTACAGCCAGTAGTAATGGTGGCCAACAGCAGCTACAAATTGCAACACCATTGAATTCAGCGGGAAGTGTTGGTAGTAATAATTGCAATGGCGGTTCTGTAGGCACTACTTCAAACAGTGTCGGCGGCGGCCTTATTGATGTGGGTAGTGATTCAGTTTATGATAAATTACGTTTACTAAATGGTCATTATCATCATCATCACACGCATGCGCACAATCAGAGTGCTCAAGCGGCTGCAGCTGCTGCAGCAGCAGCCGGATGTTGGCCACGAGCACCGCCGTCCTGGTATTCGACACCGTTAAATGGAGGTTCACCGTTTCCGTCTTCATTGCAGCCTTTAAGCCCTAGCGGTGGGTCAGTTGGCTCAGTGTTGGGCGTTGGTAGTTGTCCTATAACACCCGAAGATATTCATTTGAAAAAAGAACTCGATGGTCATCATTCGGATGAAACTGGATCGGGTGAAGGTGATAATTCGAATGCTGGTTCAAATTTAGGTGCCAACGATGATGATCAAGCCCGACTTATTTTGAAGCGCAAATTACAGCGAAATCGTACGTCATTTACCAACGATCAAATTGACAGTTTAGAAAAAGAATTTGAACGAACCCACTATCCTGATGTTTTCGCACGTGAACGACTAGCTGCAAAAATTGGTCTACCCGAAGCACGCATCcaagtttggttttccaatcgacgtgccaaatggcgtcgtgaggaaaaattgcgaaatcaaCGTCGAACGCCTAATAATACAACAACAACTTCATCGTCCTCATCAACACCAGGCGGCAATGCTCTAGGCAGTGGTGGCGAAAGTGGCAGCAATGGCAGTGGTGGTGTTGGCGGCCTTGCCATCAATAATAATCCAACTGCAGGCGCCGGCGGTGGAGGTGGTAAGTTTACAACTAATAGTCATCAAGCATTCCAACTCTACTCACTTGGTCGTAATGCAGCCATCACTTCAATGACAGATCTCAGTCCACCACCATCACTAAACAATGGCGGAACACCAACATCATCCGATCATCATCACATGCATCATCATCATCAATCTCAAAGTGGCAGGGGTCTGCTTGGTTCGAGTTTGGGCTTAGGCAATTCGCATCATCTTGCGTCATCGGCTGTGCAATCGCTGTCTCCGCGTTTAAATTTGAATAGTGGATTCAGCAGTACAATGGGCGCCATGTATTCAACAGTGCATCATCCTCCAATGCCAATGAGTGATTCATATAGTCCAATGACATCGATGTCCTCGTTTACGCATCCATCAATTACATCCATGCCCTCATCACCAAACATAGGTATCGTCCCATCGGGCATTTCAGCGGCATCAGCAACGAGTTGCTTGCAGCAGCATCAGCGCGATCTCACTCCACCGTCACTTTACCAATGTCATATGTCACTGCGCGGACCCATTCCACCACCTGTTGGAGGTTCATTTTCGTCCCATAATTCGTCAGGAGGCAGCAGCGGTGGTGTTCCAGGCAGTGGTGGTGGTGGTTCCTCAACTCCCAACTCCGGAATTCCACCACCACCACTCTCACATCCTTCCACACCGACACATCCGCATCCAGCTGCTGCGGCAGCAGCTGCAGCTGCAGCAGCTTATGACTCACTAGGCCTCAGCGGCTATGGGCCACCACCACCTCCACCGCCAACCGCTCCCAGCGACGCTCGTCACTCACCATGCAGTCCACATCAAGGCTATCAAATGGCTGGAGCAGGCTCGGTTGTCCAATCAAGTGCGTATTCTTCGGGAAACAATAACAACAACAGCAGCACAGGTAAACAATTCTTTGCCTCATGTTTTTATTCACCGTGGGTTTAA
Protein Sequence
MFALQPTPAMGAVVAPWSGSMMDRIPSLDDMPHKDNVIAMRNLQYMGTGKAAAVDTTTAESSSTPTHSSSSSSSSSYFAATTYYHLTDDECHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVNKISQYKRECPSIFAWEIRDRLLQDGVCTNDNIPSVSSINRVLRNLAAQKEQQQHPSSNQQGSGGTGGTSGGSTASSNGGQQQLQIATPLNSAGSVGSNNCNGGSVGTTSNSVGGGLIDVGSDSVYDKLRLLNGHYHHHHTHAHNQSAQAAAAAAAAAGCWPRAPPSWYSTPLNGGSPFPSSLQPLSPSGGSVGSVLGVGSCPITPEDIHLKKELDGHHSDETGSGEGDNSNAGSNLGANDDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAAKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNNTTTTSSSSSTPGGNALGSGGESGSNGSGGVGGLAINNNPTAGAGGGGGKFTTNSHQAFQLYSLGRNAAITSMTDLSPPPSLNNGGTPTSSDHHHMHHHHQSQSGRGLLGSSLGLGNSHHLASSAVQSLSPRLNLNSGFSSTMGAMYSTVHHPPMPMSDSYSPMTSMSSFTHPSITSMPSSPNIGIVPSGISAASATSCLQQHQRDLTPPSLYQCHMSLRGPIPPPVGGSFSSHNSSGGSSGGVPGSGGGGSSTPNSGIPPPPLSHPSTPTHPHPAAAAAAAAAAAYDSLGLSGYGPPPPPPPTAPSDARHSPCSPHQGYQMAGAGSVVQSSAYSSGNNNNNSSTGKQFFASCFYSPWV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00240667;
90% Identity
iTF_00426189; iTF_01396466; iTF_01396330; iTF_00665587; iTF_00665478; iTF_00334808; iTF_00334986; iTF_00693625; iTF_00693767; iTF_00663900; iTF_00664010; iTF_00426975; iTF_00427101;
80% Identity
iTF_00426189;