Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.32 1.2e+03 -0.5 0.0 26 44 46 64 37 71 0.82

2 5 4.8e-05 0.18 11.7 0.2 23 46 71 94 65 97 0.91

3 5 4.6e-05 0.17 11.8 0.2 20 48 96 123 93 125 0.89

4 5 0.0024 9.3 6.2 0.1 22 52 126 156 124 156 0.88

5 5 3.9e-05 0.15 12.0 0.1 20 45 152 177 150 182 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.32	1.2e+03	-0.5	0.0	26	44	46	64	37	71	0.82
2	5	4.8e-05	0.18	11.7	0.2	23	46	71	94	65	97	0.91
3	5	4.6e-05	0.17	11.8	0.2	20	48	96	123	93	125	0.89
4	5	0.0024	9.3	6.2	0.1	22	52	126	156	124	156	0.88
5	5	3.9e-05	0.15	12.0	0.1	20	45	152	177	150	182	0.90

Coding Sequence: ATGGAGGAACCTAAACCAGTCGATATAAAGCCAGTCTACACTTGCCGGAGATGCAAAATTACTTTCAGCACAAAACGTGAATCTTTACTTCATCGTAAAACTGTACATGAATCGAATCCAGAGGACAACAAATATGTATGCGAAATTTGCAACAAGGGTTTCGCAAATCCTGGAAACATGTATCGTCACGTGAAAGGTCATAACGACGTAAGGCCGCACAGTTGTAAAATTTGCGGAAGAGCTTTTGCACAAGCAGCGAATTTACAAAGGCATTTATCAGTACACAACGGAGAGAGACCATACTCTTGTTTAGTTTGCGAGAAAAGTTTTACACAACAGGGAAACTTGCGTCGTCATGAGCTCACCCATACCGGAGAGAAGCCTTTCCGTTGCAAAAGATGTGGAAGAATGTTTTCACAGAGAGTGAATTTGAAGAAACACGTTATGCTGCACCAGGGCTACAAACCTTTCAACTGCGAAATATGCCATAAATCATTTTTACAATCTCAAAACTATAAGAAGCATGTGGAAAAACATGCACCAAATCAGACAACTTACAAAGCTGAAAAGACCGAATTGTATTACGAGTGCGCCTTATGTCGAGTAGTGTTCGCAAATCTTGAAGAATTCCAATCGCATGAAATATTCTGTGAGGTTGCAGGAGAGGAGCAAATTGAAACTACAACTGAATTGGTTGAAAGTGCTTAG
Protein Sequence: MEEPKPVDIKPVYTCRRCKITFSTKRESLLHRKTVHESNPEDNKYVCEICNKGFANPGNMYRHVKGHNDVRPHSCKICGRAFAQAANLQRHLSVHNGERPYSCLVCEKSFTQQGNLRRHELTHTGEKPFRCKRCGRMFSQRVNLKKHVMLHQGYKPFNCEICHKSFLQSQNYKKHVEKHAPNQTTYKAEKTELYYECALCRVVFANLEEFQSHEIFCEVAGEEQIETTTELVESA

Sequence clustering based on sequence similarity using MMseqs2