Basic Information

Gene Symbol
RREB1
Assembly
GCA_006980735.1
Location
jcf7180002939721:18128-25262[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.056 3.8 7.9 0.6 2 21 164 183 164 185 0.94
2 14 0.00025 0.017 15.4 0.2 1 23 195 217 195 217 0.98
3 14 1.7e-05 0.0012 19.0 7.5 1 23 223 245 223 245 0.98
4 14 0.03 2 8.8 2.0 2 21 391 410 391 411 0.94
5 14 1.2 78 3.8 0.3 1 20 454 473 454 475 0.76
6 14 0.0065 0.44 10.9 0.1 1 23 609 631 609 631 0.97
7 14 2.4e-05 0.0016 18.6 0.9 1 23 640 662 640 662 0.99
8 14 0.00061 0.041 14.1 2.0 1 23 668 691 668 691 0.97
9 14 0.0007 0.047 13.9 2.1 1 23 1015 1038 1015 1038 0.95
10 14 6.3e-05 0.0043 17.2 0.3 2 23 1328 1349 1327 1349 0.97
11 14 0.11 7.2 7.1 6.3 1 23 1355 1378 1355 1378 0.97
12 14 2.9 2e+02 2.6 6.0 1 23 1438 1460 1438 1461 0.94
13 14 0.0062 0.42 11.0 0.5 3 23 1508 1528 1506 1528 0.96
14 14 0.001 0.069 13.4 4.8 1 23 1534 1556 1534 1556 0.99

Sequence Information

Coding Sequence
ATGATTAGATCAAACAATGCACAACACAAAATGGATCAAAAAAGGGAAAGACGTTCATCTTCAACATCGGAATCATCTTTAGAGCCCATGGATCTTGGTAGAAGTCCGAAAAAACCTGGCAGCCATGAATCAGCCAATTTTTCATCAACTTTAACGAATTCAGTGAATAATGATTCAGACAATTACGAATCGGACAATGATGATTATGCCAATAATCGTATCAGTGAAACTCATGTAGAAATTGAACCAAGTGATAACCCACATTCGTTGCGCAAAAAATTTCGAATAAGTACACCGAATAAAAACAACAATAGCCTGAGTAAAAATAATAACAATAATAATAGTATGACATATTCAAAAACTAATGAAACGACACAATCAGCTGGTGATCGTACAAATAATGAATCGGGATTCGTTGATACGAGCAGTCACCATTTAAACTCTAGTCCAGATTCTGGTGCAGAACGTGATCGGGAGGATACAAAACGAGTTTGTCCAATATGTGAGGCTGTCTCGGCCACCGCTCATGAATTTACAAATCACATTCGATGCCACAACTATTCTTCGGGTGATTCTGAGAATTTCACTTGTCGCATATGTTCCAAGGTGCTATCATCAGCATCATCTCTGGATCGCCATGTGTTGGTCCACACGGGAGAGCGGCCGTTCAATTGCAAATATTGTCACCTGACATTTACAACAAATGGCAATATGCATCGTCACATGCGAACCCACAAACAGCATCAACAGCAGCGTAATACTGGCACAATCGGTAATAATGTTGGTAGCGGTGGCGTTGGCGGTGGTGGCGGCGGCAGCGGTGTCGGTGGCAATGGAGGAGGTAGTACCAGTAATAGTGGGCCAAGTAGTGGCAGCAGCGGTGGCGGTGGTGATGGCGAAAGTTATGAAAGCGATGGTTGCTCAACAGACTCAAATGCCAGTAGCTCAAATAACAACAACAATAACAATTATAAGCGCAAAAGTGTAGACGATGATAACGGAATAATAAAAAGACGCATGAAGACCATCAACAACAACATAATCAATGAAAATGAGACCGAGCCCCAAACCGGGCTCAAGTACTGTTGTATAGTGTGCAATCGCAATGACTTCATTAGTATGCTTGCCCTGAGTACCCACATGGATCGCGAACATCCAGGCATTCCAGCTAAATGTCGGCAATGTGAGATCGTTTTTAAGACGCATAAAGCTTTAAATGCTCACAGGTGCGCGAATAAAGTGAACATAACTCAGGGCTTCAAAGATATTACCTTTGTGGACTTTTCTAGTGAAAAGTTTCCACTAATAGCAAAATCTTTGTGCGAACAGACCATAAGAACACCAATTACAAGTCAAAAGTTCGAATGCCCCAAGTGTTATCGGGCCTTTCCATGTGCCAGTGCTGTCGATATTCACATTAAAGACTGTGGGGAATCTCCACAAGACTTCTCTCTGCGTAAACGTGCAACAAGTGAAAGCTCGGATGAGGAAAATCGGCGCGATGAATTTTTTGCTCATTTAGATCTACAGAACAAGTCTGCAATGAGTTTGGCTAGTTCAATGTCATCCCCCCGAACATCAGAAAAATCAGATATCAAGGCAGATCCAGAGAAATCACCCCAGCAGAACTACAAACAACAAGAGTCGAGGGACTTAGCCGACATCCAGTCAATTTTAAATGTTACATCGTCCTCCAGTAGTTTTATAAGGAATTTTGAGAAGTGCGTCAACACACCCAACAGTGAGTACAGCTACGGGAAGGACGAAGAAGAAGCTCAGGACGCATTTACTTCTGAATTCAGAAAAATGAAATTACGAGGAGAATTCCCCTGCAAATTATGCACAGCTGTTTTTCCAAACTTACGGGCGTTAAAAGGACACAATCGAATTCACCTGAGTGCAGCTGGGGCCGGACCATACCGTTGCAATATGTGCCCATATTCCATTCACGACAAAGCTGCTCTCATCCGACACATGCGTACCCACAATGGTGACAGACCATATGAATGTGCTGTCTGCAATTACGCTTTCACCACGAAAGCCAACTGTGAACGACACCTTCGGAATAGACATTCCAAAACTACTCGGGAAGAGGTGAAACGTGCCATTATTTATCACCCGTCCGAAGATTCTGGTTGTGACGACCCCATTAAAAAAATGCACCTATTTTCCTCACCAGAACTTGATCACGATGACGAGCACAGTATACTCAAAGATCGATCAACTCCTGTATCACATTTGAAAGAAATGTTACAGTCGGAGAAGCCAGTAAAAATACAAGTGAAGAGCTTAGAGAAATTGATTGACAAGACCTTCAAGAGCTATGAAGAACAGGAGAAAGAAACCTTAGAAGCGGAACAGAACAACGACTCTAACCGACCCATAGACCTGAGCATGGATGTTTTAGATCTAAGTAAGAAATCAAAGTCTAATCCACCACTTCAAGACAGAGCTGAACCAGAGACCCCCTCAGAACAACCCAAGGTTGATATAGCAATGATTGAGAAAAATAATCAAATTTTACTTGCTCAACAACAGCTTTTAAACGAAGCATTGCCTAAGGTGGATCCATCCCATTACTTCCAGCTGTCACAGTTGTACAGGAATTTTTTCTCGCCATTCCATTCATTCTTCCTCCAAAACAGCTTGCTGCCTAACAATATGAGCGATCACACCAAGTTTCCTCCAAACATGCTAATGAACTCCATGTTTAGTGGCAGTGGTGAACATAGAGTAACATCTCAGAATTCGAACAGTGTAGGCAGTCAGTGTCAAGCACCACCCCACTCACAACAAATCCAGAGCAATGTGATTGACAATTCTATGATGAAGAGCACACCACAAACTACCCAAATAATGCAAAAGGCCATGCCGCTTACATCTCCACAAATCAACATTCCTCGTCATCCTCACCTGGGTCAACCTCCTCCCCAACCTCCTTTAGTTCCTCCAAGTCAGAATTCTGGGCCAGTTAAAATGGTAATCAAGAACGGGGTATTAATGCCGAAGCAGAAACAGCGGCGTTACAGAACCGAACGTCCGTTTGCTTGCGAGCATTGCTCAGCCCGGTTTACATTGAGATCAAATATGGAACGTCACATCAAGCAACAGCATCCGCAATATTGGGCACAAAGGCAAAGAAGTGGTCATCATATAATGCGGCGTAGCAGTAACACTGCCGCGATATCGCAAATTCCATCAAATACACTTCCACCTTCTGTCCCAAACATGCCTACCCCACATTTTACCGCAATATCTGACCAAGTAAAGTATGCTATACTTGCACAACAGCTAAAGGCCAGGAAGGACACAGATATTCTGCAACAAACACTTTCTCAAGGCAACAGCAGCAACAACCATACTAACAGTGGCAATTTTAATAGTACAAATAATTCAAGCAGCAACATTAACACAAACGTCGAAGATGATGATCCCAAGCTCGTTATTGATGAGGACGAGGATATTGAAAATGAAGAAGTAGATGACGATCCCAAACCTGAAGATCTTTCCAAAAGTAACGAGGCTAACCAAGAAAATTCCGTCGCGAAGAAAGTGGCAGACTCGATCCTAGAGCAAGCTATTAGAGCCAGCAATAACCCAGCCAAGCATGTCTCATCACCCAGTAGCACAGAAATCACAGAAAGTAAGGATTTTAATCTAAAAATTGCCAGCAATATGATAGCTCGAGCGGAATCAGTTGGAAAATATTTGAAGGAGGTCGCAAGCTCTCCTTTCAAAGACGAATCCTCTGACCTTGTTTCAGTTTCTAAACTAGTCGACAATGCCACAAATTCCATGTCCTTTAACAATTACTTCCGCCCAAGTGACTTGCCAAATCAAATGGAACAAAGTGATGAGGAAGGTTTGGTAGCTTCAGGCAGTGCTTCAGAAAGCAATAACTCAGGAACCGAGGAGACTCAAAGCACCGTGGGTCATGATCAGAAAAAGAAGTCAGCCTACAGTCTAGCCCCAAATCGAGTATCATGCCCATATTGCCAACGAATGTTTCCATGGTCAAGTTCTTTGCGTAGGCACATCCTAACTCACACCGGACAAAAGCCATTCAAATGCTCTCATTGCCCACTTTTATTCACAACGAAGAGCAACTGTGATCGTCATTTGTTGAGGAAGCATGGAAATGTTGAATCTGCGGTATCACTTTATGTTCCTATTGATGACATTCCAGATCCGGTTCCCACTCCAAAAGTTACCGAGGAGACGGAACAAATAAAACAAGTAAATTCTATAAATGTAAACTTAAACGTTCCAAGCATTAAACCAGAGCCGATGATTTCCTCCTCAGATCTTCCGTTCAAATGTCACCTATGTGATAGTTCCTTCGCTGAAAGGACCCAATGTTTGGGTCACATAAAAATGCACCATGCTCAAGAGTACGCTCTGTTGATAGCGAAAGGCGCTATTGATGCGGATGCAGACTACAACCAAACACAATTAGCTGATGACGATGAAAGAAATGATGGCCGCGGCAAGTATCCCGATTATGCTAACCGAAAAGTGATATGTGCTTTTTGTGTGCGACGATTTTGGTCTACAGAAGATTTAAGGCGACATATGCGAACACATTCTGGTGAACGGCCATTTCAATGCGACATTTGCCTCAGGAAATTCACCTTAAAGCACAGTATGCTGCGACACATGAAAAAGCATAGCGGAAGTCACCACAATAGTCAATCAAATACAACAAACAGTGGATCAGATATGTCGGATGATGAACAGCCCTCCAGTATGGTCCTTAACAACACACTCAGAAGCCATAAAATCCAAGAAATCCTGAGCAAAGCAGAAGCTTGGAGAAAAAGTCATTTGAGTGGTGAACAAAAGGAAAACATTGCCCTGCAACCGTTTATAAAAAGTGAAGGAAATGGTGAAGATAATAATTCAGATCTCATCGGAAATCTGCTGGGCATCAGCGATCAGGGAATTCTAAACAAACTTTTATCTTCAGCTGATGAAGCAGCAAAACTGCTGGGCGTTGAGAAATAA
Protein Sequence
MIRSNNAQHKMDQKRERRSSSTSESSLEPMDLGRSPKKPGSHESANFSSTLTNSVNNDSDNYESDNDDYANNRISETHVEIEPSDNPHSLRKKFRISTPNKNNNSLSKNNNNNNSMTYSKTNETTQSAGDRTNNESGFVDTSSHHLNSSPDSGAERDREDTKRVCPICEAVSATAHEFTNHIRCHNYSSGDSENFTCRICSKVLSSASSLDRHVLVHTGERPFNCKYCHLTFTTNGNMHRHMRTHKQHQQQRNTGTIGNNVGSGGVGGGGGGSGVGGNGGGSTSNSGPSSGSSGGGGDGESYESDGCSTDSNASSSNNNNNNNYKRKSVDDDNGIIKRRMKTINNNIINENETEPQTGLKYCCIVCNRNDFISMLALSTHMDREHPGIPAKCRQCEIVFKTHKALNAHRCANKVNITQGFKDITFVDFSSEKFPLIAKSLCEQTIRTPITSQKFECPKCYRAFPCASAVDIHIKDCGESPQDFSLRKRATSESSDEENRRDEFFAHLDLQNKSAMSLASSMSSPRTSEKSDIKADPEKSPQQNYKQQESRDLADIQSILNVTSSSSSFIRNFEKCVNTPNSEYSYGKDEEEAQDAFTSEFRKMKLRGEFPCKLCTAVFPNLRALKGHNRIHLSAAGAGPYRCNMCPYSIHDKAALIRHMRTHNGDRPYECAVCNYAFTTKANCERHLRNRHSKTTREEVKRAIIYHPSEDSGCDDPIKKMHLFSSPELDHDDEHSILKDRSTPVSHLKEMLQSEKPVKIQVKSLEKLIDKTFKSYEEQEKETLEAEQNNDSNRPIDLSMDVLDLSKKSKSNPPLQDRAEPETPSEQPKVDIAMIEKNNQILLAQQQLLNEALPKVDPSHYFQLSQLYRNFFSPFHSFFLQNSLLPNNMSDHTKFPPNMLMNSMFSGSGEHRVTSQNSNSVGSQCQAPPHSQQIQSNVIDNSMMKSTPQTTQIMQKAMPLTSPQINIPRHPHLGQPPPQPPLVPPSQNSGPVKMVIKNGVLMPKQKQRRYRTERPFACEHCSARFTLRSNMERHIKQQHPQYWAQRQRSGHHIMRRSSNTAAISQIPSNTLPPSVPNMPTPHFTAISDQVKYAILAQQLKARKDTDILQQTLSQGNSSNNHTNSGNFNSTNNSSSNINTNVEDDDPKLVIDEDEDIENEEVDDDPKPEDLSKSNEANQENSVAKKVADSILEQAIRASNNPAKHVSSPSSTEITESKDFNLKIASNMIARAESVGKYLKEVASSPFKDESSDLVSVSKLVDNATNSMSFNNYFRPSDLPNQMEQSDEEGLVASGSASESNNSGTEETQSTVGHDQKKKSAYSLAPNRVSCPYCQRMFPWSSSLRRHILTHTGQKPFKCSHCPLLFTTKSNCDRHLLRKHGNVESAVSLYVPIDDIPDPVPTPKVTEETEQIKQVNSINVNLNVPSIKPEPMISSSDLPFKCHLCDSSFAERTQCLGHIKMHHAQEYALLIAKGAIDADADYNQTQLADDDERNDGRGKYPDYANRKVICAFCVRRFWSTEDLRRHMRTHSGERPFQCDICLRKFTLKHSMLRHMKKHSGSHHNSQSNTTNSGSDMSDDEQPSSMVLNNTLRSHKIQEILSKAEAWRKSHLSGEQKENIALQPFIKSEGNGEDNNSDLIGNLLGISDQGILNKLLSSADEAAKLLGVEK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01184049;
90% Identity
-
80% Identity
-